Genome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height

• Autor(a) principal: Utsunomiya, Yuri T. [UNESP]
• Data de Publicação: 2013
• Outros Autores: do Carmo, Adriana S. [UNESP], Carvalheiro, Roberto, Neves, Haroldo H.R. [UNESP], Matos, Márcia C. [UNESP], Zavarez, Ludmilla B. [UNESP], Pérez O'Brien, Ana M., Sölkner, Johann, McEwan, John C., Cole, John B., Van Tassell, Curtis P., Schenkel, Flávio S., da Silva, Marcos V.G.B., Porto Neto, Laercio R., Sonstegard, Tad S., Garcia, José Fernando [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1186/1471-2156-14-52; http://hdl.handle.net/11449/75650
• topic: Birth weight; Bos primigenius indicus; GWAS; Nellore cattle; Stature; CHCHD7 protein; MOS protein; PENK protein; PLAG1 protein; protein kinase Lyn; protein tyrosine kinase; RDHE2 protein; RPS20 protein; SDR16C5 protein; unclassified drug; animal experiment; animal tissue; autosome; birth weight; body height; Bos taurus; breeding; carcass; cattle; chromosome NOR; controlled study; gene expression; gene location; gene mapping; genetic association; genetic linkage; genotype; gestational age; nonhuman; orthology; progeny; quantitative trait locus; single nucleotide polymorphism; swine; weaning; weight gain; Bos; Bos indicus; Bovinae; Suidae

Background: Birth weight (BW) is an economically important trait in beef cattle, and is associated with growth- and stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs).Results: The most significant SNP (rs133012258, PGC = 1.34 × 10-9), located at BTA14:25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with human, pig and mouse autosomes 8, 4 and 4, respectively, and contains the orthologous height genes PLAG1, CHCHD7, MOS, RPS20, LYN, RDHE2 (SDR16C5) and PENK. The region also overlapped 28 quantitative trait loci (QTLs) previously reported in literature by linkage mapping studies in cattle, including QTLs for birth weight, mature height, carcass weight, stature, pre-weaning average daily gain, calving ease, and gestation length.Conclusions: This study presents the first GWAS applying a high-density SNP panel to identify putative chromosome regions affecting birth weight in Nellore cattle. These results suggest that the QTLs on BTA14 associated with body size in taurine cattle (Bos primigenius taurus) also affect birth weight and size in zebu cattle (Bos primigenius indicus). © 2013 Utsunomiya et al.; licensee BioMed Central Ltd.