Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.106187 http://hdl.handle.net/11449/229840 |
Resumo: | Objective: Patterns of cytokine levels and their association with stroke severity, infarct size, and muscle strength are obscure. We aimed to analyze the immune mediators linked to T helper (Th)1, Th2, Th17, and regulatory T cell patterns and their association with stroke severity, infarct size, and muscle strength. Materials and methods: We included patients with acute stroke (n = 15) and healthy non-disabled individuals (n = 20) aged > 18 years. The dependent variables were stroke severity according to the National Institute of Health Stroke Scale (NIHSS), infarct size on computed tomography, handgrip strength by dynamometry, and global muscle strength according to the Medical Research Council (MRC) scale. The independent variables were the circulating cytokine levels. The cytokine levels were compared between the groups, and correlations between the clinical data were verified. Results: The stroke group had higher interleukin (IL)-6 (p < 0.0001) and IL-10 (p < 0.0001) levels, but lower tumor necrosis factor (TNF)-α (p = 0.036) levels than the control group. IL-10 and soluble tumor necrosis factor receptor (sTNF-RII) levels were correlated with each other (r = 0.533; p = 0.042) and infarct size (r = 0.653; p = 0.033 and r = 0.689; p = 0.018, respectively). MRC scores were positively and negatively correlated with handgrip strength of the affected side (r = 0.78; p = 0.001) and NIHSS scores (r = -0.87; p < 0.0001), respectively. Conclusions: Plasma levels of some cytokines were associated with changes in the acute phase of stroke, and IL-10 and sTNF-RII levels are potential biomarkers of infarct size. |
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Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of StrokeAcute stroke phaseCytokinesInfarct sizeMuscle strengthStrokeStroke severityObjective: Patterns of cytokine levels and their association with stroke severity, infarct size, and muscle strength are obscure. We aimed to analyze the immune mediators linked to T helper (Th)1, Th2, Th17, and regulatory T cell patterns and their association with stroke severity, infarct size, and muscle strength. Materials and methods: We included patients with acute stroke (n = 15) and healthy non-disabled individuals (n = 20) aged > 18 years. The dependent variables were stroke severity according to the National Institute of Health Stroke Scale (NIHSS), infarct size on computed tomography, handgrip strength by dynamometry, and global muscle strength according to the Medical Research Council (MRC) scale. The independent variables were the circulating cytokine levels. The cytokine levels were compared between the groups, and correlations between the clinical data were verified. Results: The stroke group had higher interleukin (IL)-6 (p < 0.0001) and IL-10 (p < 0.0001) levels, but lower tumor necrosis factor (TNF)-α (p = 0.036) levels than the control group. IL-10 and soluble tumor necrosis factor receptor (sTNF-RII) levels were correlated with each other (r = 0.533; p = 0.042) and infarct size (r = 0.653; p = 0.033 and r = 0.689; p = 0.018, respectively). MRC scores were positively and negatively correlated with handgrip strength of the affected side (r = 0.78; p = 0.001) and NIHSS scores (r = -0.87; p < 0.0001), respectively. Conclusions: Plasma levels of some cytokines were associated with changes in the acute phase of stroke, and IL-10 and sTNF-RII levels are potential biomarkers of infarct size.Department of Applied Physical Therapy Federal University of Triângulo MineiroDepartment of Microbiology Immunology and Parasitology Federal University of Triângulo MineiroDepartment of Neurology Psychology and Psychiatry Botucatu Medical SchoolClinics Hospital of the Federal University of Triângulo MineiroDepartment of Neurology Psychology and Psychiatry Botucatu Medical SchoolFederal University of Triângulo MineiroUniversidade Estadual Paulista (UNESP)Bitencourt, Ana Carolina SilvaTimóteo, Rodolfo PessatoBazan, Rodrigo [UNESP]Silva, Marcos Viníciusda Silveira Filho, Luiz GonzagaRatkevicius, Cristhianne Molinero Andradede Assunção, Thaís Soares Farneside Oliveira, Ana Paula SilvaLuvizutto, Gustavo José2022-04-29T08:36:12Z2022-04-29T08:36:12Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.106187Journal of Stroke and Cerebrovascular Diseases, v. 31, n. 1, 2022.1532-85111052-3057http://hdl.handle.net/11449/22984010.1016/j.jstrokecerebrovasdis.2021.1061872-s2.0-85118588226Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Stroke and Cerebrovascular Diseasesinfo:eu-repo/semantics/openAccess2024-08-16T15:45:29Zoai:repositorio.unesp.br:11449/229840Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T15:45:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke |
title |
Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke |
spellingShingle |
Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke Bitencourt, Ana Carolina Silva Acute stroke phase Cytokines Infarct size Muscle strength Stroke Stroke severity |
title_short |
Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke |
title_full |
Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke |
title_fullStr |
Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke |
title_full_unstemmed |
Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke |
title_sort |
Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke |
author |
Bitencourt, Ana Carolina Silva |
author_facet |
Bitencourt, Ana Carolina Silva Timóteo, Rodolfo Pessato Bazan, Rodrigo [UNESP] Silva, Marcos Vinícius da Silveira Filho, Luiz Gonzaga Ratkevicius, Cristhianne Molinero Andrade de Assunção, Thaís Soares Farnesi de Oliveira, Ana Paula Silva Luvizutto, Gustavo José |
author_role |
author |
author2 |
Timóteo, Rodolfo Pessato Bazan, Rodrigo [UNESP] Silva, Marcos Vinícius da Silveira Filho, Luiz Gonzaga Ratkevicius, Cristhianne Molinero Andrade de Assunção, Thaís Soares Farnesi de Oliveira, Ana Paula Silva Luvizutto, Gustavo José |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Federal University of Triângulo Mineiro Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Bitencourt, Ana Carolina Silva Timóteo, Rodolfo Pessato Bazan, Rodrigo [UNESP] Silva, Marcos Vinícius da Silveira Filho, Luiz Gonzaga Ratkevicius, Cristhianne Molinero Andrade de Assunção, Thaís Soares Farnesi de Oliveira, Ana Paula Silva Luvizutto, Gustavo José |
dc.subject.por.fl_str_mv |
Acute stroke phase Cytokines Infarct size Muscle strength Stroke Stroke severity |
topic |
Acute stroke phase Cytokines Infarct size Muscle strength Stroke Stroke severity |
description |
Objective: Patterns of cytokine levels and their association with stroke severity, infarct size, and muscle strength are obscure. We aimed to analyze the immune mediators linked to T helper (Th)1, Th2, Th17, and regulatory T cell patterns and their association with stroke severity, infarct size, and muscle strength. Materials and methods: We included patients with acute stroke (n = 15) and healthy non-disabled individuals (n = 20) aged > 18 years. The dependent variables were stroke severity according to the National Institute of Health Stroke Scale (NIHSS), infarct size on computed tomography, handgrip strength by dynamometry, and global muscle strength according to the Medical Research Council (MRC) scale. The independent variables were the circulating cytokine levels. The cytokine levels were compared between the groups, and correlations between the clinical data were verified. Results: The stroke group had higher interleukin (IL)-6 (p < 0.0001) and IL-10 (p < 0.0001) levels, but lower tumor necrosis factor (TNF)-α (p = 0.036) levels than the control group. IL-10 and soluble tumor necrosis factor receptor (sTNF-RII) levels were correlated with each other (r = 0.533; p = 0.042) and infarct size (r = 0.653; p = 0.033 and r = 0.689; p = 0.018, respectively). MRC scores were positively and negatively correlated with handgrip strength of the affected side (r = 0.78; p = 0.001) and NIHSS scores (r = -0.87; p < 0.0001), respectively. Conclusions: Plasma levels of some cytokines were associated with changes in the acute phase of stroke, and IL-10 and sTNF-RII levels are potential biomarkers of infarct size. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:36:12Z 2022-04-29T08:36:12Z 2022-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.106187 Journal of Stroke and Cerebrovascular Diseases, v. 31, n. 1, 2022. 1532-8511 1052-3057 http://hdl.handle.net/11449/229840 10.1016/j.jstrokecerebrovasdis.2021.106187 2-s2.0-85118588226 |
url |
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.106187 http://hdl.handle.net/11449/229840 |
identifier_str_mv |
Journal of Stroke and Cerebrovascular Diseases, v. 31, n. 1, 2022. 1532-8511 1052-3057 10.1016/j.jstrokecerebrovasdis.2021.106187 2-s2.0-85118588226 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Stroke and Cerebrovascular Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128126078681088 |