Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke

Detalhes bibliográficos
Autor(a) principal: Bitencourt, Ana Carolina Silva
Data de Publicação: 2022
Outros Autores: Timóteo, Rodolfo Pessato, Bazan, Rodrigo [UNESP], Silva, Marcos Vinícius, da Silveira Filho, Luiz Gonzaga, Ratkevicius, Cristhianne Molinero Andrade, de Assunção, Thaís Soares Farnesi, de Oliveira, Ana Paula Silva, Luvizutto, Gustavo José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.106187
http://hdl.handle.net/11449/229840
Resumo: Objective: Patterns of cytokine levels and their association with stroke severity, infarct size, and muscle strength are obscure. We aimed to analyze the immune mediators linked to T helper (Th)1, Th2, Th17, and regulatory T cell patterns and their association with stroke severity, infarct size, and muscle strength. Materials and methods: We included patients with acute stroke (n = 15) and healthy non-disabled individuals (n = 20) aged > 18 years. The dependent variables were stroke severity according to the National Institute of Health Stroke Scale (NIHSS), infarct size on computed tomography, handgrip strength by dynamometry, and global muscle strength according to the Medical Research Council (MRC) scale. The independent variables were the circulating cytokine levels. The cytokine levels were compared between the groups, and correlations between the clinical data were verified. Results: The stroke group had higher interleukin (IL)-6 (p < 0.0001) and IL-10 (p < 0.0001) levels, but lower tumor necrosis factor (TNF)-α (p = 0.036) levels than the control group. IL-10 and soluble tumor necrosis factor receptor (sTNF-RII) levels were correlated with each other (r = 0.533; p = 0.042) and infarct size (r = 0.653; p = 0.033 and r = 0.689; p = 0.018, respectively). MRC scores were positively and negatively correlated with handgrip strength of the affected side (r = 0.78; p = 0.001) and NIHSS scores (r = -0.87; p < 0.0001), respectively. Conclusions: Plasma levels of some cytokines were associated with changes in the acute phase of stroke, and IL-10 and sTNF-RII levels are potential biomarkers of infarct size.
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spelling Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of StrokeAcute stroke phaseCytokinesInfarct sizeMuscle strengthStrokeStroke severityObjective: Patterns of cytokine levels and their association with stroke severity, infarct size, and muscle strength are obscure. We aimed to analyze the immune mediators linked to T helper (Th)1, Th2, Th17, and regulatory T cell patterns and their association with stroke severity, infarct size, and muscle strength. Materials and methods: We included patients with acute stroke (n = 15) and healthy non-disabled individuals (n = 20) aged > 18 years. The dependent variables were stroke severity according to the National Institute of Health Stroke Scale (NIHSS), infarct size on computed tomography, handgrip strength by dynamometry, and global muscle strength according to the Medical Research Council (MRC) scale. The independent variables were the circulating cytokine levels. The cytokine levels were compared between the groups, and correlations between the clinical data were verified. Results: The stroke group had higher interleukin (IL)-6 (p < 0.0001) and IL-10 (p < 0.0001) levels, but lower tumor necrosis factor (TNF)-α (p = 0.036) levels than the control group. IL-10 and soluble tumor necrosis factor receptor (sTNF-RII) levels were correlated with each other (r = 0.533; p = 0.042) and infarct size (r = 0.653; p = 0.033 and r = 0.689; p = 0.018, respectively). MRC scores were positively and negatively correlated with handgrip strength of the affected side (r = 0.78; p = 0.001) and NIHSS scores (r = -0.87; p < 0.0001), respectively. Conclusions: Plasma levels of some cytokines were associated with changes in the acute phase of stroke, and IL-10 and sTNF-RII levels are potential biomarkers of infarct size.Department of Applied Physical Therapy Federal University of Triângulo MineiroDepartment of Microbiology Immunology and Parasitology Federal University of Triângulo MineiroDepartment of Neurology Psychology and Psychiatry Botucatu Medical SchoolClinics Hospital of the Federal University of Triângulo MineiroDepartment of Neurology Psychology and Psychiatry Botucatu Medical SchoolFederal University of Triângulo MineiroUniversidade Estadual Paulista (UNESP)Bitencourt, Ana Carolina SilvaTimóteo, Rodolfo PessatoBazan, Rodrigo [UNESP]Silva, Marcos Viníciusda Silveira Filho, Luiz GonzagaRatkevicius, Cristhianne Molinero Andradede Assunção, Thaís Soares Farneside Oliveira, Ana Paula SilvaLuvizutto, Gustavo José2022-04-29T08:36:12Z2022-04-29T08:36:12Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.106187Journal of Stroke and Cerebrovascular Diseases, v. 31, n. 1, 2022.1532-85111052-3057http://hdl.handle.net/11449/22984010.1016/j.jstrokecerebrovasdis.2021.1061872-s2.0-85118588226Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Stroke and Cerebrovascular Diseasesinfo:eu-repo/semantics/openAccess2024-08-16T15:45:29Zoai:repositorio.unesp.br:11449/229840Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T15:45:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke
title Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke
spellingShingle Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke
Bitencourt, Ana Carolina Silva
Acute stroke phase
Cytokines
Infarct size
Muscle strength
Stroke
Stroke severity
title_short Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke
title_full Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke
title_fullStr Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke
title_full_unstemmed Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke
title_sort Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke
author Bitencourt, Ana Carolina Silva
author_facet Bitencourt, Ana Carolina Silva
Timóteo, Rodolfo Pessato
Bazan, Rodrigo [UNESP]
Silva, Marcos Vinícius
da Silveira Filho, Luiz Gonzaga
Ratkevicius, Cristhianne Molinero Andrade
de Assunção, Thaís Soares Farnesi
de Oliveira, Ana Paula Silva
Luvizutto, Gustavo José
author_role author
author2 Timóteo, Rodolfo Pessato
Bazan, Rodrigo [UNESP]
Silva, Marcos Vinícius
da Silveira Filho, Luiz Gonzaga
Ratkevicius, Cristhianne Molinero Andrade
de Assunção, Thaís Soares Farnesi
de Oliveira, Ana Paula Silva
Luvizutto, Gustavo José
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Federal University of Triângulo Mineiro
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Bitencourt, Ana Carolina Silva
Timóteo, Rodolfo Pessato
Bazan, Rodrigo [UNESP]
Silva, Marcos Vinícius
da Silveira Filho, Luiz Gonzaga
Ratkevicius, Cristhianne Molinero Andrade
de Assunção, Thaís Soares Farnesi
de Oliveira, Ana Paula Silva
Luvizutto, Gustavo José
dc.subject.por.fl_str_mv Acute stroke phase
Cytokines
Infarct size
Muscle strength
Stroke
Stroke severity
topic Acute stroke phase
Cytokines
Infarct size
Muscle strength
Stroke
Stroke severity
description Objective: Patterns of cytokine levels and their association with stroke severity, infarct size, and muscle strength are obscure. We aimed to analyze the immune mediators linked to T helper (Th)1, Th2, Th17, and regulatory T cell patterns and their association with stroke severity, infarct size, and muscle strength. Materials and methods: We included patients with acute stroke (n = 15) and healthy non-disabled individuals (n = 20) aged > 18 years. The dependent variables were stroke severity according to the National Institute of Health Stroke Scale (NIHSS), infarct size on computed tomography, handgrip strength by dynamometry, and global muscle strength according to the Medical Research Council (MRC) scale. The independent variables were the circulating cytokine levels. The cytokine levels were compared between the groups, and correlations between the clinical data were verified. Results: The stroke group had higher interleukin (IL)-6 (p < 0.0001) and IL-10 (p < 0.0001) levels, but lower tumor necrosis factor (TNF)-α (p = 0.036) levels than the control group. IL-10 and soluble tumor necrosis factor receptor (sTNF-RII) levels were correlated with each other (r = 0.533; p = 0.042) and infarct size (r = 0.653; p = 0.033 and r = 0.689; p = 0.018, respectively). MRC scores were positively and negatively correlated with handgrip strength of the affected side (r = 0.78; p = 0.001) and NIHSS scores (r = -0.87; p < 0.0001), respectively. Conclusions: Plasma levels of some cytokines were associated with changes in the acute phase of stroke, and IL-10 and sTNF-RII levels are potential biomarkers of infarct size.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-29T08:36:12Z
2022-04-29T08:36:12Z
2022-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.106187
Journal of Stroke and Cerebrovascular Diseases, v. 31, n. 1, 2022.
1532-8511
1052-3057
http://hdl.handle.net/11449/229840
10.1016/j.jstrokecerebrovasdis.2021.106187
2-s2.0-85118588226
url http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.106187
http://hdl.handle.net/11449/229840
identifier_str_mv Journal of Stroke and Cerebrovascular Diseases, v. 31, n. 1, 2022.
1532-8511
1052-3057
10.1016/j.jstrokecerebrovasdis.2021.106187
2-s2.0-85118588226
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Stroke and Cerebrovascular Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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