Efeitos da fenilbutazona na cicatrização de feridas cutâneas experimentais em equinos
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.revistas.usp.br/bjvras/article/view/26824 http://hdl.handle.net/11449/72184 |
Resumo: | The purpose of this study was to investigate phenylbutazone effects on second intention wound healing, and to compare the healing process between the thoracic and lumbar areas. Ten horses were submitted to circular full-thickness wound produced on both sides of the thoracic and lumbar areas. Animals were gathered into two experimental groups, one receiving daily IV injections of phenylbutazone (4,4mg/kg) and the other (control group) distillated water for five days. All wounds were daily treated with local Dakin's solution. The wound contraction rates were determined by serial measurements each 72 hours. At the 6th and 15th post surgical days, biopsies were performed for histological analysis. Thoracic and lumbar wound contraction was decreased in the phenylbutazone group. The time to complete healing was significantly greater in phenylbutazone group (49 days) than in control group (37 days). There was no significant difference between thoracic and lumbar area in the same group. Gross and histopathology analysis showed the inhibitory effect of phenylbutazone on the second-intention wound healing when compared to the control group. |
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Efeitos da fenilbutazona na cicatrização de feridas cutâneas experimentais em equinosPhenylbutazone effects on experimental wound healing in horsesHealingHorsesPhenylbutazoneWoundAnimaliaEquidaeThe purpose of this study was to investigate phenylbutazone effects on second intention wound healing, and to compare the healing process between the thoracic and lumbar areas. Ten horses were submitted to circular full-thickness wound produced on both sides of the thoracic and lumbar areas. Animals were gathered into two experimental groups, one receiving daily IV injections of phenylbutazone (4,4mg/kg) and the other (control group) distillated water for five days. All wounds were daily treated with local Dakin's solution. The wound contraction rates were determined by serial measurements each 72 hours. At the 6th and 15th post surgical days, biopsies were performed for histological analysis. Thoracic and lumbar wound contraction was decreased in the phenylbutazone group. The time to complete healing was significantly greater in phenylbutazone group (49 days) than in control group (37 days). There was no significant difference between thoracic and lumbar area in the same group. Gross and histopathology analysis showed the inhibitory effect of phenylbutazone on the second-intention wound healing when compared to the control group.Departamento de Cirurgia e Anestesiologia Veterinária Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista, Botucatu-SP, CEP 18618-000Departamento de Bioestatística Instituto de Biociências Universidade Estadual Paulista, Botucatu-SPDepartamento de Cirurgia e Anestesiologia Veterinária Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista, Botucatu-SP, CEP 18618-000Departamento de Bioestatística Instituto de Biociências Universidade Estadual Paulista, Botucatu-SPUniversidade Estadual Paulista (Unesp)Hussni, Carlos Alberto [UNESP]Groh, Tanja Melanie [UNESP]Alves, Ana Liz Garcia [UNESP]Crocci, Adalberto José [UNESP]de Mello Nicoletti, José Luiz [UNESP]Watanabe, Marcos Jun [UNESP]2014-05-27T11:25:24Z2014-05-27T11:25:24Z2010-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article262-267application/pdfhttp://www.revistas.usp.br/bjvras/article/view/26824Brazilian Journal of Veterinary Research and Animal Science, v. 47, n. 4, p. 262-267, 2010.1413-95961678-4456http://hdl.handle.net/11449/721842-s2.0-797515124802-s2.0-79751512480.pdf7989397951395253Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporBrazilian Journal of Veterinary Research and Animal Science0,2250,225info:eu-repo/semantics/openAccess2023-11-08T06:16:07Zoai:repositorio.unesp.br:11449/72184Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:12:08.158031Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Efeitos da fenilbutazona na cicatrização de feridas cutâneas experimentais em equinos Phenylbutazone effects on experimental wound healing in horses |
title |
Efeitos da fenilbutazona na cicatrização de feridas cutâneas experimentais em equinos |
spellingShingle |
Efeitos da fenilbutazona na cicatrização de feridas cutâneas experimentais em equinos Hussni, Carlos Alberto [UNESP] Healing Horses Phenylbutazone Wound Animalia Equidae |
title_short |
Efeitos da fenilbutazona na cicatrização de feridas cutâneas experimentais em equinos |
title_full |
Efeitos da fenilbutazona na cicatrização de feridas cutâneas experimentais em equinos |
title_fullStr |
Efeitos da fenilbutazona na cicatrização de feridas cutâneas experimentais em equinos |
title_full_unstemmed |
Efeitos da fenilbutazona na cicatrização de feridas cutâneas experimentais em equinos |
title_sort |
Efeitos da fenilbutazona na cicatrização de feridas cutâneas experimentais em equinos |
author |
Hussni, Carlos Alberto [UNESP] |
author_facet |
Hussni, Carlos Alberto [UNESP] Groh, Tanja Melanie [UNESP] Alves, Ana Liz Garcia [UNESP] Crocci, Adalberto José [UNESP] de Mello Nicoletti, José Luiz [UNESP] Watanabe, Marcos Jun [UNESP] |
author_role |
author |
author2 |
Groh, Tanja Melanie [UNESP] Alves, Ana Liz Garcia [UNESP] Crocci, Adalberto José [UNESP] de Mello Nicoletti, José Luiz [UNESP] Watanabe, Marcos Jun [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Hussni, Carlos Alberto [UNESP] Groh, Tanja Melanie [UNESP] Alves, Ana Liz Garcia [UNESP] Crocci, Adalberto José [UNESP] de Mello Nicoletti, José Luiz [UNESP] Watanabe, Marcos Jun [UNESP] |
dc.subject.por.fl_str_mv |
Healing Horses Phenylbutazone Wound Animalia Equidae |
topic |
Healing Horses Phenylbutazone Wound Animalia Equidae |
description |
The purpose of this study was to investigate phenylbutazone effects on second intention wound healing, and to compare the healing process between the thoracic and lumbar areas. Ten horses were submitted to circular full-thickness wound produced on both sides of the thoracic and lumbar areas. Animals were gathered into two experimental groups, one receiving daily IV injections of phenylbutazone (4,4mg/kg) and the other (control group) distillated water for five days. All wounds were daily treated with local Dakin's solution. The wound contraction rates were determined by serial measurements each 72 hours. At the 6th and 15th post surgical days, biopsies were performed for histological analysis. Thoracic and lumbar wound contraction was decreased in the phenylbutazone group. The time to complete healing was significantly greater in phenylbutazone group (49 days) than in control group (37 days). There was no significant difference between thoracic and lumbar area in the same group. Gross and histopathology analysis showed the inhibitory effect of phenylbutazone on the second-intention wound healing when compared to the control group. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12-01 2014-05-27T11:25:24Z 2014-05-27T11:25:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.revistas.usp.br/bjvras/article/view/26824 Brazilian Journal of Veterinary Research and Animal Science, v. 47, n. 4, p. 262-267, 2010. 1413-9596 1678-4456 http://hdl.handle.net/11449/72184 2-s2.0-79751512480 2-s2.0-79751512480.pdf 7989397951395253 |
url |
http://www.revistas.usp.br/bjvras/article/view/26824 http://hdl.handle.net/11449/72184 |
identifier_str_mv |
Brazilian Journal of Veterinary Research and Animal Science, v. 47, n. 4, p. 262-267, 2010. 1413-9596 1678-4456 2-s2.0-79751512480 2-s2.0-79751512480.pdf 7989397951395253 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science 0,225 0,225 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
262-267 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128770297561088 |