Sistemas líquidos cristalinos a base de quitosana e polietilenoimina para a administração cutânea de metronidazol

• Autor(a) principal: Victorelli, Francesca Damiani [UNESP]
• Data de Publicação: 2015
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/140210; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2016-06-17/000863705.pdf
• topic: Quitosana; Metronidazol; Polímeros; Chitosan

The antibiotics of systemic release can cause bacterial resistance and are administered in high doses, causing high toxicity to organs. Metronidazole has potent activity against the majority of anaerobic gram-positive and gram-negative bacteria and protozoa; and its topical administration can be advantageous because of the few systemic effects. However, the use of this route of administration presents a great obstacle due to the difficulty of the permeation of molecules through the stratum corneum. Therefore, it becomes necessary to develop drug delivery systems, such as liquid-crystal systems (LCS) with cationic polymeric adjuvants, to allow the use of this route of administration with therapeutic success. This project aimed to develop an LCS constituted by cetyl alcohol ethoxylate and propxilado (Procetyl® AWS) as surfactant (T), oleic acid as the oil phase (OF) and aqueous phase (AP) containing polymer dispersion of chitosan (F1), polyethyleneimine (F2) or association of polymers (F3) to metronidazole administration. Systems have been developed using polymer dispersions, Procetyl® AWS and oleic acid, it is possible to define regions as transparent liquid system (TLS), translucent liquid system (TRLS), opaque liquid system (OLS), transparent viscous system (TVS), translucent low viscosity system (TRLVS), translucent high viscosity system (TRHVS), opaque viscous system (OVS) or phase separation (PS). One formulation of each system was selected for the characterization tests, determining the concentration of T and AF in 40% and of OF in 20%.The analysis of polarized light microscopy showed anisotropic structures in the form of splines, characteristics of hexagonal phase, for formulations F1, F2 and F3. Rheological tests showed thixotropic behavior of the formulations. The MTZ was incorporated at 0.5% in the formulations, which are now called F1-F, F2-F and F3-F. Release tests showed that the formulations F1-F, F2-F, and F3-F released drug...