The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/ hepatitis C virus coinfected patients
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0037-8682-0152-2015 http://hdl.handle.net/11449/172031 |
Resumo: | Introduction: Hepatic fibrosis progression in patients with chronic hepatitis C virus infections has been associated with viral and host factors, including genetic polymorphisms. Human platelet antigen polymorphisms are associated with the rapid development of fibrosis in HCV-monoinfected patients. This study aimed to determine whether such an association exists in human immunodeficiency virus-1/hepatitis C virus-coinfected patients. Methods: Genomic deoxyribonucleic acid from 36 human immunodeficiency virus-1/hepatitis C virus-coinfected patients was genotyped to determine the presence of human platelet antigens-1, -3, or -5 polymorphisms. Fibrosis progression was evaluated using the Metavir scoring system, and the patients were assigned to two groups, namely, G1 that comprised patients with F1, portal fibrosis without septa, or F2, few septa (n = 23) and G2 that comprised patients with F3, numerous septa, or F4, cirrhosis (n = 13). Fisher’s exact test was utilized to determine possible associations between the human platelet antigen polymorphisms and fibrosis progression. Results: There were no deviations from the Hardy-Weinberg equilibrium in the human platelet antigen systems evaluated. Statistically significant differences were not observed between G1 and G2 with respect to the distributions of the allelic and genotypic frequencies of the human platelet antigen systems. Conclusions: The greater stimulation of hepatic stellate cells by the human immunodeficiency virus and, consequently, the increased expression of transforming growth factor beta can offset the effect of human platelet antigen polymorphism on the progression of fibrosis in patients coinfected with the human immunodeficiency virus-1 and the hepatitis C virus. |
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The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/ hepatitis C virus coinfected patientsCoinfectionHepatitis C virusHuman immunodeficiency virusHuman platelet antigenLiver fibrosisIntroduction: Hepatic fibrosis progression in patients with chronic hepatitis C virus infections has been associated with viral and host factors, including genetic polymorphisms. Human platelet antigen polymorphisms are associated with the rapid development of fibrosis in HCV-monoinfected patients. This study aimed to determine whether such an association exists in human immunodeficiency virus-1/hepatitis C virus-coinfected patients. Methods: Genomic deoxyribonucleic acid from 36 human immunodeficiency virus-1/hepatitis C virus-coinfected patients was genotyped to determine the presence of human platelet antigens-1, -3, or -5 polymorphisms. Fibrosis progression was evaluated using the Metavir scoring system, and the patients were assigned to two groups, namely, G1 that comprised patients with F1, portal fibrosis without septa, or F2, few septa (n = 23) and G2 that comprised patients with F3, numerous septa, or F4, cirrhosis (n = 13). Fisher’s exact test was utilized to determine possible associations between the human platelet antigen polymorphisms and fibrosis progression. Results: There were no deviations from the Hardy-Weinberg equilibrium in the human platelet antigen systems evaluated. Statistically significant differences were not observed between G1 and G2 with respect to the distributions of the allelic and genotypic frequencies of the human platelet antigen systems. Conclusions: The greater stimulation of hepatic stellate cells by the human immunodeficiency virus and, consequently, the increased expression of transforming growth factor beta can offset the effect of human platelet antigen polymorphism on the progression of fibrosis in patients coinfected with the human immunodeficiency virus-1 and the hepatitis C virus.Laboratório de Biologia Molecular do Hemocentro Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESPDepartamento de Bioprocessos e Biotecnologia Fazenda Experimental Lageado Universidade Estadual Paulista “Júlio de Mesquita Filho”- UNESPDepartamento de Clínica Médica Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESPDepartamento de Doenças Tropicais Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESPDepartamento de Bioestatística Instituto de Biociências de Botucatu Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESPLaboratório de Biologia Molecular do Hemocentro Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESPDepartamento de Bioprocessos e Biotecnologia Fazenda Experimental Lageado Universidade Estadual Paulista “Júlio de Mesquita Filho”- UNESPDepartamento de Clínica Médica Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESPDepartamento de Doenças Tropicais Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESPDepartamento de Bioestatística Instituto de Biociências de Botucatu Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESPUniversidade Estadual Paulista (Unesp)Picelli, Natália [UNESP]Tanikawa, Aline Aki [UNESP]Grotto, Rejane Maria Tommasini [UNESP]Silva, Giovanni Faria [UNESP]Barbosa, Alexandre Naime [UNESP]Ferrasi, Adriana Camargo [UNESP]de Arruda Silveira, Liciana Vaz [UNESP]Pardini, Maria Inês de Moura Campos [UNESP]2018-12-11T16:58:12Z2018-12-11T16:58:12Z2015-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article406-409application/pdfhttp://dx.doi.org/10.1590/0037-8682-0152-2015Revista da Sociedade Brasileira de Medicina Tropical, v. 48, n. 4, p. 406-409, 2015.0037-8682http://hdl.handle.net/11449/17203110.1590/0037-8682-0152-2015S0037-868220150004004062-s2.0-84940375378S0037-86822015000400406.pdf3587895085226224461958833458208477884485643265850000-0001-9200-53910000-0002-4035-9486Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista da Sociedade Brasileira de Medicina Tropical0,658info:eu-repo/semantics/openAccess2023-11-10T06:10:28Zoai:repositorio.unesp.br:11449/172031Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:17:54.715978Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/ hepatitis C virus coinfected patients |
title |
The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/ hepatitis C virus coinfected patients |
spellingShingle |
The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/ hepatitis C virus coinfected patients Picelli, Natália [UNESP] Coinfection Hepatitis C virus Human immunodeficiency virus Human platelet antigen Liver fibrosis |
title_short |
The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/ hepatitis C virus coinfected patients |
title_full |
The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/ hepatitis C virus coinfected patients |
title_fullStr |
The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/ hepatitis C virus coinfected patients |
title_full_unstemmed |
The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/ hepatitis C virus coinfected patients |
title_sort |
The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/ hepatitis C virus coinfected patients |
author |
Picelli, Natália [UNESP] |
author_facet |
Picelli, Natália [UNESP] Tanikawa, Aline Aki [UNESP] Grotto, Rejane Maria Tommasini [UNESP] Silva, Giovanni Faria [UNESP] Barbosa, Alexandre Naime [UNESP] Ferrasi, Adriana Camargo [UNESP] de Arruda Silveira, Liciana Vaz [UNESP] Pardini, Maria Inês de Moura Campos [UNESP] |
author_role |
author |
author2 |
Tanikawa, Aline Aki [UNESP] Grotto, Rejane Maria Tommasini [UNESP] Silva, Giovanni Faria [UNESP] Barbosa, Alexandre Naime [UNESP] Ferrasi, Adriana Camargo [UNESP] de Arruda Silveira, Liciana Vaz [UNESP] Pardini, Maria Inês de Moura Campos [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Picelli, Natália [UNESP] Tanikawa, Aline Aki [UNESP] Grotto, Rejane Maria Tommasini [UNESP] Silva, Giovanni Faria [UNESP] Barbosa, Alexandre Naime [UNESP] Ferrasi, Adriana Camargo [UNESP] de Arruda Silveira, Liciana Vaz [UNESP] Pardini, Maria Inês de Moura Campos [UNESP] |
dc.subject.por.fl_str_mv |
Coinfection Hepatitis C virus Human immunodeficiency virus Human platelet antigen Liver fibrosis |
topic |
Coinfection Hepatitis C virus Human immunodeficiency virus Human platelet antigen Liver fibrosis |
description |
Introduction: Hepatic fibrosis progression in patients with chronic hepatitis C virus infections has been associated with viral and host factors, including genetic polymorphisms. Human platelet antigen polymorphisms are associated with the rapid development of fibrosis in HCV-monoinfected patients. This study aimed to determine whether such an association exists in human immunodeficiency virus-1/hepatitis C virus-coinfected patients. Methods: Genomic deoxyribonucleic acid from 36 human immunodeficiency virus-1/hepatitis C virus-coinfected patients was genotyped to determine the presence of human platelet antigens-1, -3, or -5 polymorphisms. Fibrosis progression was evaluated using the Metavir scoring system, and the patients were assigned to two groups, namely, G1 that comprised patients with F1, portal fibrosis without septa, or F2, few septa (n = 23) and G2 that comprised patients with F3, numerous septa, or F4, cirrhosis (n = 13). Fisher’s exact test was utilized to determine possible associations between the human platelet antigen polymorphisms and fibrosis progression. Results: There were no deviations from the Hardy-Weinberg equilibrium in the human platelet antigen systems evaluated. Statistically significant differences were not observed between G1 and G2 with respect to the distributions of the allelic and genotypic frequencies of the human platelet antigen systems. Conclusions: The greater stimulation of hepatic stellate cells by the human immunodeficiency virus and, consequently, the increased expression of transforming growth factor beta can offset the effect of human platelet antigen polymorphism on the progression of fibrosis in patients coinfected with the human immunodeficiency virus-1 and the hepatitis C virus. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-07-01 2018-12-11T16:58:12Z 2018-12-11T16:58:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0037-8682-0152-2015 Revista da Sociedade Brasileira de Medicina Tropical, v. 48, n. 4, p. 406-409, 2015. 0037-8682 http://hdl.handle.net/11449/172031 10.1590/0037-8682-0152-2015 S0037-86822015000400406 2-s2.0-84940375378 S0037-86822015000400406.pdf 3587895085226224 4619588334582084 7788448564326585 0000-0001-9200-5391 0000-0002-4035-9486 |
url |
http://dx.doi.org/10.1590/0037-8682-0152-2015 http://hdl.handle.net/11449/172031 |
identifier_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical, v. 48, n. 4, p. 406-409, 2015. 0037-8682 10.1590/0037-8682-0152-2015 S0037-86822015000400406 2-s2.0-84940375378 S0037-86822015000400406.pdf 3587895085226224 4619588334582084 7788448564326585 0000-0001-9200-5391 0000-0002-4035-9486 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical 0,658 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
406-409 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128787137691648 |