Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/molecules19068124 http://hdl.handle.net/11449/113440 |
Resumo: | Ethyl ferulate (FAEE) has been widely studied due to its beneficial heath properties and, when incorporated in creams, shows a high sun protection capacity. Here we aimed to compare FAEE and its precursor, ferulic acid (FA), as free radical scavengers, inhibitors of oxidants produced by leukocytes and the alterations in rheological properties when incorporated in emulsion based creams. The cell-free antiradical capacity of FAEE was decreased compared to FA. However, FAEE was more effective regarding the scavenging of reactive oxygen species produced by activated leukocytes. Stress and frequency sweep tests showed that the formulations are more elastic than viscous. The viscoelastic features of the formulations were confirmed in the creep and recovery assay and showed that the FAEE formulation was less susceptive to deformation. Liberation experiments showed that the rate of FAEE release from the emulsion was slower compared to FA. In conclusion, FAEE is more effective than FA as a potential inhibitor of oxidative damage produced by oxidants generated by leukocytes. The rheological alterations caused by the addition of FAEE are indicative of lower spreadability, which could be useful for formulations used in restricted areas of the skin. |
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Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based CreamsneutrophilNADPH oxidaseoxidative stressferulic acidethyl ferulatecosmetic productEthyl ferulate (FAEE) has been widely studied due to its beneficial heath properties and, when incorporated in creams, shows a high sun protection capacity. Here we aimed to compare FAEE and its precursor, ferulic acid (FA), as free radical scavengers, inhibitors of oxidants produced by leukocytes and the alterations in rheological properties when incorporated in emulsion based creams. The cell-free antiradical capacity of FAEE was decreased compared to FA. However, FAEE was more effective regarding the scavenging of reactive oxygen species produced by activated leukocytes. Stress and frequency sweep tests showed that the formulations are more elastic than viscous. The viscoelastic features of the formulations were confirmed in the creep and recovery assay and showed that the FAEE formulation was less susceptive to deformation. Liberation experiments showed that the rate of FAEE release from the emulsion was slower compared to FA. In conclusion, FAEE is more effective than FA as a potential inhibitor of oxidative damage produced by oxidants generated by leukocytes. The rheological alterations caused by the addition of FAEE are indicative of lower spreadability, which could be useful for formulations used in restricted areas of the skin.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista, UNESP, Dept Anal Clin, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, BrazilUniv Estadual Paulista, UNESP, Dept Cosmetol, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, BrazilUniv Estadual Paulista, UNESP, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, Dept Quim Organ,Inst Quim, BR-14800900 Araraquara, SP, BrazilUniv Estadual Paulista, UNESP, Dept Quim, Fac Ciencias, BR-17033360 Bauru, SP, BrazilUniv Estadual Paulista, UNESP, Dept Anal Clin, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, BrazilUniv Estadual Paulista, UNESP, Dept Cosmetol, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, BrazilUniv Estadual Paulista, UNESP, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, Dept Quim Organ,Inst Quim, BR-14800900 Araraquara, SP, BrazilUniv Estadual Paulista, UNESP, Dept Quim, Fac Ciencias, BR-17033360 Bauru, SP, BrazilMdpi AgUniversidade Estadual Paulista (Unesp)Nazare, Ana C. [UNESP]Faria, Carolina M. Q. G. de [UNESP]Chiari, Bruna G. [UNESP]Petronio, Maicon S. [UNESP]Regasini, Luis O. [UNESP]Silva, Dulce Helena Siqueira [UNESP]Correa, Marcos A. [UNESP]Isaac, Vera L. B. [UNESP]Fonseca, Luiz M. da [UNESP]Ximenes, Valdecir F. [UNESP]2014-12-03T13:11:42Z2014-12-03T13:11:42Z2014-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8124-8139application/pdfhttp://dx.doi.org/10.3390/molecules19068124Molecules. Basel: Mdpi Ag, v. 19, n. 6, p. 8124-8139, 2014.1420-3049http://hdl.handle.net/11449/11344010.3390/molecules19068124WOS:000338586700074WOS000338586700074.pdf47020049042312480000-0002-1516-77650000-0002-1516-7765Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMolecules3.0980,855info:eu-repo/semantics/openAccess2024-06-21T15:18:56Zoai:repositorio.unesp.br:11449/113440Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:59:08.836939Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams |
title |
Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams |
spellingShingle |
Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams Nazare, Ana C. [UNESP] neutrophil NADPH oxidase oxidative stress ferulic acid ethyl ferulate cosmetic product |
title_short |
Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams |
title_full |
Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams |
title_fullStr |
Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams |
title_full_unstemmed |
Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams |
title_sort |
Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams |
author |
Nazare, Ana C. [UNESP] |
author_facet |
Nazare, Ana C. [UNESP] Faria, Carolina M. Q. G. de [UNESP] Chiari, Bruna G. [UNESP] Petronio, Maicon S. [UNESP] Regasini, Luis O. [UNESP] Silva, Dulce Helena Siqueira [UNESP] Correa, Marcos A. [UNESP] Isaac, Vera L. B. [UNESP] Fonseca, Luiz M. da [UNESP] Ximenes, Valdecir F. [UNESP] |
author_role |
author |
author2 |
Faria, Carolina M. Q. G. de [UNESP] Chiari, Bruna G. [UNESP] Petronio, Maicon S. [UNESP] Regasini, Luis O. [UNESP] Silva, Dulce Helena Siqueira [UNESP] Correa, Marcos A. [UNESP] Isaac, Vera L. B. [UNESP] Fonseca, Luiz M. da [UNESP] Ximenes, Valdecir F. [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Nazare, Ana C. [UNESP] Faria, Carolina M. Q. G. de [UNESP] Chiari, Bruna G. [UNESP] Petronio, Maicon S. [UNESP] Regasini, Luis O. [UNESP] Silva, Dulce Helena Siqueira [UNESP] Correa, Marcos A. [UNESP] Isaac, Vera L. B. [UNESP] Fonseca, Luiz M. da [UNESP] Ximenes, Valdecir F. [UNESP] |
dc.subject.por.fl_str_mv |
neutrophil NADPH oxidase oxidative stress ferulic acid ethyl ferulate cosmetic product |
topic |
neutrophil NADPH oxidase oxidative stress ferulic acid ethyl ferulate cosmetic product |
description |
Ethyl ferulate (FAEE) has been widely studied due to its beneficial heath properties and, when incorporated in creams, shows a high sun protection capacity. Here we aimed to compare FAEE and its precursor, ferulic acid (FA), as free radical scavengers, inhibitors of oxidants produced by leukocytes and the alterations in rheological properties when incorporated in emulsion based creams. The cell-free antiradical capacity of FAEE was decreased compared to FA. However, FAEE was more effective regarding the scavenging of reactive oxygen species produced by activated leukocytes. Stress and frequency sweep tests showed that the formulations are more elastic than viscous. The viscoelastic features of the formulations were confirmed in the creep and recovery assay and showed that the FAEE formulation was less susceptive to deformation. Liberation experiments showed that the rate of FAEE release from the emulsion was slower compared to FA. In conclusion, FAEE is more effective than FA as a potential inhibitor of oxidative damage produced by oxidants generated by leukocytes. The rheological alterations caused by the addition of FAEE are indicative of lower spreadability, which could be useful for formulations used in restricted areas of the skin. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-03T13:11:42Z 2014-12-03T13:11:42Z 2014-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/molecules19068124 Molecules. Basel: Mdpi Ag, v. 19, n. 6, p. 8124-8139, 2014. 1420-3049 http://hdl.handle.net/11449/113440 10.3390/molecules19068124 WOS:000338586700074 WOS000338586700074.pdf 4702004904231248 0000-0002-1516-7765 0000-0002-1516-7765 |
url |
http://dx.doi.org/10.3390/molecules19068124 http://hdl.handle.net/11449/113440 |
identifier_str_mv |
Molecules. Basel: Mdpi Ag, v. 19, n. 6, p. 8124-8139, 2014. 1420-3049 10.3390/molecules19068124 WOS:000338586700074 WOS000338586700074.pdf 4702004904231248 0000-0002-1516-7765 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Molecules 3.098 0,855 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
8124-8139 application/pdf |
dc.publisher.none.fl_str_mv |
Mdpi Ag |
publisher.none.fl_str_mv |
Mdpi Ag |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128881583980544 |