Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: Potential material for biomedical applications
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ceramint.2018.08.136 http://hdl.handle.net/11449/171333 |
Resumo: | Nano-sized zinc oxide (ZnO) is well known for its antibacterial activity and biocompatibility, which make this material a promising candidate to tailor titanium (Ti) implant surfaces. In an optimized scenario, the antibacterial activity of ZnO and its biocompatibility can be envisioned as a good bio-functionalization strategy to increase osteointegration. Thus, in this work, it is proposed that the bio-functionalization of ZnO thin films with dentin matrix protein 1 (DMP1) peptides could function as an apatite crystal nucleator. Ti was coated with ZnO and functionalized with two different spacers, 3-(4-aminophenyl) propionic acid (APPA) or 3-mercaptopropionic acid (MPA) to facilitate binding with DMP1 peptides. Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS) results confirmed the presence of the peptides on the ZnO thin film surface through characteristic bands related to amine and carboxylic acid groups and by the incidence of N 1 s spectra, respectively. Atomic force microscopy (AFM) images indicated that a more uniform layer of DMP1 peptides is formed in the the presence of the APPA and MPA spacers. In general, the results obtained showed that the bio-functionalized ZnO thin films with APPA spacer, ZnO APPA P sample, presented enhanced wettability (17°), surface energy (72 dyn/cm), with an osteogenic surface and apatite nucleating properties. Furthermore, the electrochemical analysis showed increased corrosion resistance with noble EOCP (−0.13 V), Ecorr (−0.46 V), and Icorr (8.91 ×10−7 A/cm2) values. These findings indicated promising applications of ZnO APPA P in biomedical devices once it can accelerate the osteointegration process and improve the corrosion resistance of implants. |
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Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: Potential material for biomedical applicationsBio-functionalizationCorrosion resistanceFunctional materialsOsteogenic peptidesZinc oxideNano-sized zinc oxide (ZnO) is well known for its antibacterial activity and biocompatibility, which make this material a promising candidate to tailor titanium (Ti) implant surfaces. In an optimized scenario, the antibacterial activity of ZnO and its biocompatibility can be envisioned as a good bio-functionalization strategy to increase osteointegration. Thus, in this work, it is proposed that the bio-functionalization of ZnO thin films with dentin matrix protein 1 (DMP1) peptides could function as an apatite crystal nucleator. Ti was coated with ZnO and functionalized with two different spacers, 3-(4-aminophenyl) propionic acid (APPA) or 3-mercaptopropionic acid (MPA) to facilitate binding with DMP1 peptides. Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS) results confirmed the presence of the peptides on the ZnO thin film surface through characteristic bands related to amine and carboxylic acid groups and by the incidence of N 1 s spectra, respectively. Atomic force microscopy (AFM) images indicated that a more uniform layer of DMP1 peptides is formed in the the presence of the APPA and MPA spacers. In general, the results obtained showed that the bio-functionalized ZnO thin films with APPA spacer, ZnO APPA P sample, presented enhanced wettability (17°), surface energy (72 dyn/cm), with an osteogenic surface and apatite nucleating properties. Furthermore, the electrochemical analysis showed increased corrosion resistance with noble EOCP (−0.13 V), Ecorr (−0.46 V), and Icorr (8.91 ×10−7 A/cm2) values. These findings indicated promising applications of ZnO APPA P in biomedical devices once it can accelerate the osteointegration process and improve the corrosion resistance of implants.National Institutes of HealthFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State University (Unesp) School of SciencesDepartment of Oral Biology College of Dentistry University of Illinois at ChicagoDepartment of Biomedical Sciences College of Medicine at Rockford University of Illinois-School of Medicine at RockfordSão Paulo State University (Unesp) School of SciencesNational Institutes of Health: 11657FAPESP: 2013/07296-2; 2013/09963-6; 2014/01713-3; 2014/27015-0; 2017/15035-5Universidade Estadual Paulista (Unesp)University of Illinois at ChicagoUniversity of Illinois-School of Medicine at RockfordTrino, Luciana D. [UNESP]Albano, Luiz G.S. [UNESP]Bronze-Uhle, Erika S. [UNESP]George, AnneMathew, Mathew T.Lisboa-Filho, Paulo N. [UNESP]2018-12-11T16:54:55Z2018-12-11T16:54:55Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.ceramint.2018.08.136Ceramics International.0272-8842http://hdl.handle.net/11449/17133310.1016/j.ceramint.2018.08.1362-s2.0-850514981552-s2.0-85051498155.pdf13538624145320050000-0002-7734-4069Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCeramics International0,784info:eu-repo/semantics/openAccess2024-01-20T06:30:47Zoai:repositorio.unesp.br:11449/171333Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:29:21.058765Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: Potential material for biomedical applications |
title |
Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: Potential material for biomedical applications |
spellingShingle |
Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: Potential material for biomedical applications Trino, Luciana D. [UNESP] Bio-functionalization Corrosion resistance Functional materials Osteogenic peptides Zinc oxide |
title_short |
Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: Potential material for biomedical applications |
title_full |
Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: Potential material for biomedical applications |
title_fullStr |
Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: Potential material for biomedical applications |
title_full_unstemmed |
Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: Potential material for biomedical applications |
title_sort |
Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: Potential material for biomedical applications |
author |
Trino, Luciana D. [UNESP] |
author_facet |
Trino, Luciana D. [UNESP] Albano, Luiz G.S. [UNESP] Bronze-Uhle, Erika S. [UNESP] George, Anne Mathew, Mathew T. Lisboa-Filho, Paulo N. [UNESP] |
author_role |
author |
author2 |
Albano, Luiz G.S. [UNESP] Bronze-Uhle, Erika S. [UNESP] George, Anne Mathew, Mathew T. Lisboa-Filho, Paulo N. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Illinois at Chicago University of Illinois-School of Medicine at Rockford |
dc.contributor.author.fl_str_mv |
Trino, Luciana D. [UNESP] Albano, Luiz G.S. [UNESP] Bronze-Uhle, Erika S. [UNESP] George, Anne Mathew, Mathew T. Lisboa-Filho, Paulo N. [UNESP] |
dc.subject.por.fl_str_mv |
Bio-functionalization Corrosion resistance Functional materials Osteogenic peptides Zinc oxide |
topic |
Bio-functionalization Corrosion resistance Functional materials Osteogenic peptides Zinc oxide |
description |
Nano-sized zinc oxide (ZnO) is well known for its antibacterial activity and biocompatibility, which make this material a promising candidate to tailor titanium (Ti) implant surfaces. In an optimized scenario, the antibacterial activity of ZnO and its biocompatibility can be envisioned as a good bio-functionalization strategy to increase osteointegration. Thus, in this work, it is proposed that the bio-functionalization of ZnO thin films with dentin matrix protein 1 (DMP1) peptides could function as an apatite crystal nucleator. Ti was coated with ZnO and functionalized with two different spacers, 3-(4-aminophenyl) propionic acid (APPA) or 3-mercaptopropionic acid (MPA) to facilitate binding with DMP1 peptides. Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS) results confirmed the presence of the peptides on the ZnO thin film surface through characteristic bands related to amine and carboxylic acid groups and by the incidence of N 1 s spectra, respectively. Atomic force microscopy (AFM) images indicated that a more uniform layer of DMP1 peptides is formed in the the presence of the APPA and MPA spacers. In general, the results obtained showed that the bio-functionalized ZnO thin films with APPA spacer, ZnO APPA P sample, presented enhanced wettability (17°), surface energy (72 dyn/cm), with an osteogenic surface and apatite nucleating properties. Furthermore, the electrochemical analysis showed increased corrosion resistance with noble EOCP (−0.13 V), Ecorr (−0.46 V), and Icorr (8.91 ×10−7 A/cm2) values. These findings indicated promising applications of ZnO APPA P in biomedical devices once it can accelerate the osteointegration process and improve the corrosion resistance of implants. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T16:54:55Z 2018-12-11T16:54:55Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ceramint.2018.08.136 Ceramics International. 0272-8842 http://hdl.handle.net/11449/171333 10.1016/j.ceramint.2018.08.136 2-s2.0-85051498155 2-s2.0-85051498155.pdf 1353862414532005 0000-0002-7734-4069 |
url |
http://dx.doi.org/10.1016/j.ceramint.2018.08.136 http://hdl.handle.net/11449/171333 |
identifier_str_mv |
Ceramics International. 0272-8842 10.1016/j.ceramint.2018.08.136 2-s2.0-85051498155 2-s2.0-85051498155.pdf 1353862414532005 0000-0002-7734-4069 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ceramics International 0,784 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129524989165568 |