Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.revistas.usp.br/bjvras/article/view/26859 http://hdl.handle.net/11449/133850 |
Resumo: | Aiming to assess the efficacy of the treatment, to verify the occurrence of possible disease relapses and to search for the presence of parasites after the treatment, seven dogs naturally infected by Leishmania sp., were submitted to a treatment with meglumine antimoniate and allopurinol. For this, lymph node and bone marrow aspiration biopsies were carried out at seven moments. After the end of the six-month observation period all dogs were submitted to euthanasia. Then, spleen and liver “imprints” and in vitro cultures were carried out to search for amastigote forms of the parasite. All animals presented remission of the symptoms and during all the observation period no dog presented relapse of the disease, although amastigote forms of the parasite were observed in two of the animals at the end of the experiment. Thus, it was possible to conclude that the treatment promotes clinical healing but it does not eliminate the parasites completely. |
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Repositório Institucional da UNESP |
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Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinolAvaliação clínica e parasitológica de cães naturalmente infectados por Leishmania (Leishmania) chagasi submetidos a tratamento com antimoniato de meglumina e alopurinolDogsVisceral leishmaniasisTreatmentAllopurinolMeglumine antimoniateCãesLeishmaniose visceralTratamentoAlopurinolAntimoniato de megluminaAiming to assess the efficacy of the treatment, to verify the occurrence of possible disease relapses and to search for the presence of parasites after the treatment, seven dogs naturally infected by Leishmania sp., were submitted to a treatment with meglumine antimoniate and allopurinol. For this, lymph node and bone marrow aspiration biopsies were carried out at seven moments. After the end of the six-month observation period all dogs were submitted to euthanasia. Then, spleen and liver “imprints” and in vitro cultures were carried out to search for amastigote forms of the parasite. All animals presented remission of the symptoms and during all the observation period no dog presented relapse of the disease, although amastigote forms of the parasite were observed in two of the animals at the end of the experiment. Thus, it was possible to conclude that the treatment promotes clinical healing but it does not eliminate the parasites completely.Com objetivo de avaliar a eficácia do tratamento, verificar a ocorrência de possíveis recidivas da doença e pesquisar a presença de parasitas após a realização do tratamento, foram utilizados sete cães naturalmente infectados por Leishmania sp., submetidos a tratamento com antimoniato de meglumina e alopurinol. Para tanto, foram realizadas punções biópsias aspirativas de linfonodos e de medula óssea em sete momentos. Após o término dos seis meses de observação, todos os cães foram submetidos à eutanásia e realizados “imprints” e cultivo in vitro do baço e fígado para a pesquisa de formas amastigotas. Todos os animais apresentaram remissão dos sintomas e durante todo o período de observação nenhum cão apresentou recidiva da doença apesar de ter sido observada a presença de formas amastigotas do parasita em dois animais, ao término do experimento. Desta forma, foi possível concluir que o tratamento promove a cura clínica, entretanto não elimina completamente os parasitas.Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdadde de Medicina Veterinária de Araçatuba, Araçatuba, Rua Clóvis Pestana, 793, Jardim Dona Amélia, CEP 16050680, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdadde de Medicina Veterinária de Araçatuba, Araçatuba, Rua Clóvis Pestana, 793, Jardim Dona Amélia, CEP 16050680, SP, BrasilUniversidade Estadual Paulista (Unesp)Ikeda-Garcia, Fabiana Augusta [UNESP]Lopes, Raimundo Souza [UNESP]Marques, Fábia JudiceCiarlini, Paulo César [UNESP]Lima, Valéria Marçal Félix de [UNESP]Morinishi, Celina KazueZanette, Maurício FrancoPerri, Silvia Helena Venturoli [UNESP]Marcondes, Mary [UNESP]2016-01-28T16:56:52Z2016-01-28T16:56:52Z2010info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article218-223application/pdfhttp://www.revistas.usp.br/bjvras/article/view/26859Brazilian Journal of Veterinary Research and Animal Science, v. 47, n. 3, p. 218-223, 2010.1413-9596http://hdl.handle.net/11449/133850ISSN1413-9596-2010-47-03-218-223.pdf361394001829950048753523378600360810837598202634181794667109001018179466710900100000-0003-1480-5208Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Veterinary Research and Animal Science0,225info:eu-repo/semantics/openAccess2024-09-04T19:15:25Zoai:repositorio.unesp.br:11449/133850Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T19:15:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol Avaliação clínica e parasitológica de cães naturalmente infectados por Leishmania (Leishmania) chagasi submetidos a tratamento com antimoniato de meglumina e alopurinol |
title |
Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol |
spellingShingle |
Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol Ikeda-Garcia, Fabiana Augusta [UNESP] Dogs Visceral leishmaniasis Treatment Allopurinol Meglumine antimoniate Cães Leishmaniose visceral Tratamento Alopurinol Antimoniato de meglumina |
title_short |
Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol |
title_full |
Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol |
title_fullStr |
Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol |
title_full_unstemmed |
Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol |
title_sort |
Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol |
author |
Ikeda-Garcia, Fabiana Augusta [UNESP] |
author_facet |
Ikeda-Garcia, Fabiana Augusta [UNESP] Lopes, Raimundo Souza [UNESP] Marques, Fábia Judice Ciarlini, Paulo César [UNESP] Lima, Valéria Marçal Félix de [UNESP] Morinishi, Celina Kazue Zanette, Maurício Franco Perri, Silvia Helena Venturoli [UNESP] Marcondes, Mary [UNESP] |
author_role |
author |
author2 |
Lopes, Raimundo Souza [UNESP] Marques, Fábia Judice Ciarlini, Paulo César [UNESP] Lima, Valéria Marçal Félix de [UNESP] Morinishi, Celina Kazue Zanette, Maurício Franco Perri, Silvia Helena Venturoli [UNESP] Marcondes, Mary [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ikeda-Garcia, Fabiana Augusta [UNESP] Lopes, Raimundo Souza [UNESP] Marques, Fábia Judice Ciarlini, Paulo César [UNESP] Lima, Valéria Marçal Félix de [UNESP] Morinishi, Celina Kazue Zanette, Maurício Franco Perri, Silvia Helena Venturoli [UNESP] Marcondes, Mary [UNESP] |
dc.subject.por.fl_str_mv |
Dogs Visceral leishmaniasis Treatment Allopurinol Meglumine antimoniate Cães Leishmaniose visceral Tratamento Alopurinol Antimoniato de meglumina |
topic |
Dogs Visceral leishmaniasis Treatment Allopurinol Meglumine antimoniate Cães Leishmaniose visceral Tratamento Alopurinol Antimoniato de meglumina |
description |
Aiming to assess the efficacy of the treatment, to verify the occurrence of possible disease relapses and to search for the presence of parasites after the treatment, seven dogs naturally infected by Leishmania sp., were submitted to a treatment with meglumine antimoniate and allopurinol. For this, lymph node and bone marrow aspiration biopsies were carried out at seven moments. After the end of the six-month observation period all dogs were submitted to euthanasia. Then, spleen and liver “imprints” and in vitro cultures were carried out to search for amastigote forms of the parasite. All animals presented remission of the symptoms and during all the observation period no dog presented relapse of the disease, although amastigote forms of the parasite were observed in two of the animals at the end of the experiment. Thus, it was possible to conclude that the treatment promotes clinical healing but it does not eliminate the parasites completely. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 2016-01-28T16:56:52Z 2016-01-28T16:56:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.revistas.usp.br/bjvras/article/view/26859 Brazilian Journal of Veterinary Research and Animal Science, v. 47, n. 3, p. 218-223, 2010. 1413-9596 http://hdl.handle.net/11449/133850 ISSN1413-9596-2010-47-03-218-223.pdf 3613940018299500 4875352337860036 0810837598202634 1817946671090010 1817946671090010 0000-0003-1480-5208 |
url |
http://www.revistas.usp.br/bjvras/article/view/26859 http://hdl.handle.net/11449/133850 |
identifier_str_mv |
Brazilian Journal of Veterinary Research and Animal Science, v. 47, n. 3, p. 218-223, 2010. 1413-9596 ISSN1413-9596-2010-47-03-218-223.pdf 3613940018299500 4875352337860036 0810837598202634 1817946671090010 0000-0003-1480-5208 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science 0,225 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
218-223 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021377079508992 |