Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol

Detalhes bibliográficos
Autor(a) principal: Ikeda-Garcia, Fabiana Augusta [UNESP]
Data de Publicação: 2010
Outros Autores: Lopes, Raimundo Souza [UNESP], Marques, Fábia Judice, Ciarlini, Paulo César [UNESP], Lima, Valéria Marçal Félix de [UNESP], Morinishi, Celina Kazue, Zanette, Maurício Franco, Perri, Silvia Helena Venturoli [UNESP], Marcondes, Mary [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.revistas.usp.br/bjvras/article/view/26859
http://hdl.handle.net/11449/133850
Resumo: Aiming to assess the efficacy of the treatment, to verify the occurrence of possible disease relapses and to search for the presence of parasites after the treatment, seven dogs naturally infected by Leishmania sp., were submitted to a treatment with meglumine antimoniate and allopurinol. For this, lymph node and bone marrow aspiration biopsies were carried out at seven moments. After the end of the six-month observation period all dogs were submitted to euthanasia. Then, spleen and liver “imprints” and in vitro cultures were carried out to search for amastigote forms of the parasite. All animals presented remission of the symptoms and during all the observation period no dog presented relapse of the disease, although amastigote forms of the parasite were observed in two of the animals at the end of the experiment. Thus, it was possible to conclude that the treatment promotes clinical healing but it does not eliminate the parasites completely.
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spelling Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinolAvaliação clínica e parasitológica de cães naturalmente infectados por Leishmania (Leishmania) chagasi submetidos a tratamento com antimoniato de meglumina e alopurinolDogsVisceral leishmaniasisTreatmentAllopurinolMeglumine antimoniateCãesLeishmaniose visceralTratamentoAlopurinolAntimoniato de megluminaAiming to assess the efficacy of the treatment, to verify the occurrence of possible disease relapses and to search for the presence of parasites after the treatment, seven dogs naturally infected by Leishmania sp., were submitted to a treatment with meglumine antimoniate and allopurinol. For this, lymph node and bone marrow aspiration biopsies were carried out at seven moments. After the end of the six-month observation period all dogs were submitted to euthanasia. Then, spleen and liver “imprints” and in vitro cultures were carried out to search for amastigote forms of the parasite. All animals presented remission of the symptoms and during all the observation period no dog presented relapse of the disease, although amastigote forms of the parasite were observed in two of the animals at the end of the experiment. Thus, it was possible to conclude that the treatment promotes clinical healing but it does not eliminate the parasites completely.Com objetivo de avaliar a eficácia do tratamento, verificar a ocorrência de possíveis recidivas da doença e pesquisar a presença de parasitas após a realização do tratamento, foram utilizados sete cães naturalmente infectados por Leishmania sp., submetidos a tratamento com antimoniato de meglumina e alopurinol. Para tanto, foram realizadas punções biópsias aspirativas de linfonodos e de medula óssea em sete momentos. Após o término dos seis meses de observação, todos os cães foram submetidos à eutanásia e realizados “imprints” e cultivo in vitro do baço e fígado para a pesquisa de formas amastigotas. Todos os animais apresentaram remissão dos sintomas e durante todo o período de observação nenhum cão apresentou recidiva da doença apesar de ter sido observada a presença de formas amastigotas do parasita em dois animais, ao término do experimento. Desta forma, foi possível concluir que o tratamento promove a cura clínica, entretanto não elimina completamente os parasitas.Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdadde de Medicina Veterinária de Araçatuba, Araçatuba, Rua Clóvis Pestana, 793, Jardim Dona Amélia, CEP 16050680, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdadde de Medicina Veterinária de Araçatuba, Araçatuba, Rua Clóvis Pestana, 793, Jardim Dona Amélia, CEP 16050680, SP, BrasilUniversidade Estadual Paulista (Unesp)Ikeda-Garcia, Fabiana Augusta [UNESP]Lopes, Raimundo Souza [UNESP]Marques, Fábia JudiceCiarlini, Paulo César [UNESP]Lima, Valéria Marçal Félix de [UNESP]Morinishi, Celina KazueZanette, Maurício FrancoPerri, Silvia Helena Venturoli [UNESP]Marcondes, Mary [UNESP]2016-01-28T16:56:52Z2016-01-28T16:56:52Z2010info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article218-223application/pdfhttp://www.revistas.usp.br/bjvras/article/view/26859Brazilian Journal of Veterinary Research and Animal Science, v. 47, n. 3, p. 218-223, 2010.1413-9596http://hdl.handle.net/11449/133850ISSN1413-9596-2010-47-03-218-223.pdf361394001829950048753523378600360810837598202634181794667109001018179466710900100000-0003-1480-5208Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Veterinary Research and Animal Science0,225info:eu-repo/semantics/openAccess2024-09-04T19:15:25Zoai:repositorio.unesp.br:11449/133850Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T19:15:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol
Avaliação clínica e parasitológica de cães naturalmente infectados por Leishmania (Leishmania) chagasi submetidos a tratamento com antimoniato de meglumina e alopurinol
title Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol
spellingShingle Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol
Ikeda-Garcia, Fabiana Augusta [UNESP]
Dogs
Visceral leishmaniasis
Treatment
Allopurinol
Meglumine antimoniate
Cães
Leishmaniose visceral
Tratamento
Alopurinol
Antimoniato de meglumina
title_short Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol
title_full Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol
title_fullStr Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol
title_full_unstemmed Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol
title_sort Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol
author Ikeda-Garcia, Fabiana Augusta [UNESP]
author_facet Ikeda-Garcia, Fabiana Augusta [UNESP]
Lopes, Raimundo Souza [UNESP]
Marques, Fábia Judice
Ciarlini, Paulo César [UNESP]
Lima, Valéria Marçal Félix de [UNESP]
Morinishi, Celina Kazue
Zanette, Maurício Franco
Perri, Silvia Helena Venturoli [UNESP]
Marcondes, Mary [UNESP]
author_role author
author2 Lopes, Raimundo Souza [UNESP]
Marques, Fábia Judice
Ciarlini, Paulo César [UNESP]
Lima, Valéria Marçal Félix de [UNESP]
Morinishi, Celina Kazue
Zanette, Maurício Franco
Perri, Silvia Helena Venturoli [UNESP]
Marcondes, Mary [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ikeda-Garcia, Fabiana Augusta [UNESP]
Lopes, Raimundo Souza [UNESP]
Marques, Fábia Judice
Ciarlini, Paulo César [UNESP]
Lima, Valéria Marçal Félix de [UNESP]
Morinishi, Celina Kazue
Zanette, Maurício Franco
Perri, Silvia Helena Venturoli [UNESP]
Marcondes, Mary [UNESP]
dc.subject.por.fl_str_mv Dogs
Visceral leishmaniasis
Treatment
Allopurinol
Meglumine antimoniate
Cães
Leishmaniose visceral
Tratamento
Alopurinol
Antimoniato de meglumina
topic Dogs
Visceral leishmaniasis
Treatment
Allopurinol
Meglumine antimoniate
Cães
Leishmaniose visceral
Tratamento
Alopurinol
Antimoniato de meglumina
description Aiming to assess the efficacy of the treatment, to verify the occurrence of possible disease relapses and to search for the presence of parasites after the treatment, seven dogs naturally infected by Leishmania sp., were submitted to a treatment with meglumine antimoniate and allopurinol. For this, lymph node and bone marrow aspiration biopsies were carried out at seven moments. After the end of the six-month observation period all dogs were submitted to euthanasia. Then, spleen and liver “imprints” and in vitro cultures were carried out to search for amastigote forms of the parasite. All animals presented remission of the symptoms and during all the observation period no dog presented relapse of the disease, although amastigote forms of the parasite were observed in two of the animals at the end of the experiment. Thus, it was possible to conclude that the treatment promotes clinical healing but it does not eliminate the parasites completely.
publishDate 2010
dc.date.none.fl_str_mv 2010
2016-01-28T16:56:52Z
2016-01-28T16:56:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.revistas.usp.br/bjvras/article/view/26859
Brazilian Journal of Veterinary Research and Animal Science, v. 47, n. 3, p. 218-223, 2010.
1413-9596
http://hdl.handle.net/11449/133850
ISSN1413-9596-2010-47-03-218-223.pdf
3613940018299500
4875352337860036
0810837598202634
1817946671090010
1817946671090010
0000-0003-1480-5208
url http://www.revistas.usp.br/bjvras/article/view/26859
http://hdl.handle.net/11449/133850
identifier_str_mv Brazilian Journal of Veterinary Research and Animal Science, v. 47, n. 3, p. 218-223, 2010.
1413-9596
ISSN1413-9596-2010-47-03-218-223.pdf
3613940018299500
4875352337860036
0810837598202634
1817946671090010
0000-0003-1480-5208
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science
0,225
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 218-223
application/pdf
dc.source.none.fl_str_mv Currículo Lattes
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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