Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia

Detalhes bibliográficos
Autor(a) principal: Corrêa, Josilene Chaves Ruela [UNESP]
Data de Publicação: 2013
Outros Autores: Hiene, Marcelo Augusto Cavaretti [UNESP], Salgado, Hérida Regina Nunes [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.4172/2155-9872.1000177
http://hdl.handle.net/11449/133745
Resumo: Sodium azumolene is a drug designed to fight Malignant Hyperthermia (MH), which is characterized by genetic predisposition and triggered by the use of inhalational anesthetics. This drug is shown as a water-soluble analogue of dantrolene sodium, 30-folds more water soluble, which gives advantages for its emergency use. To our knowledge there is no analytical method for sodium zaumolene raw material or dosage form published so far. The objective of the present investigation was to develop and validate analytical methods to achieve sodium azumolene chemical identification and quantification. The sodium azumolene was characterized regarding its thermal behavior, by differential thermal analysis and thermogravimetric analysis; Visible, UV and infrared absorption. To accurately assess the sodium Azumolene content three different analytical methods (visible and UV spectrophotometry and high performance liquid chromatography) were developed and validated. All methods showed to be linear, accurate, precise and reliable. Azumolene has shown to be equipotent to dantrolene in the treatment and prevention of an MH crisis and the great advantage compared to dantrolene is better water solubility. This study has characterized the sodium azumolene and presents new analytical methods which have not been reported so far.
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spelling Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermiaMalignant hyperthermiaSodium azumoleneUV-VISSpectrophotometryLiquid chromatographyQuality controlSodium azumolene is a drug designed to fight Malignant Hyperthermia (MH), which is characterized by genetic predisposition and triggered by the use of inhalational anesthetics. This drug is shown as a water-soluble analogue of dantrolene sodium, 30-folds more water soluble, which gives advantages for its emergency use. To our knowledge there is no analytical method for sodium zaumolene raw material or dosage form published so far. The objective of the present investigation was to develop and validate analytical methods to achieve sodium azumolene chemical identification and quantification. The sodium azumolene was characterized regarding its thermal behavior, by differential thermal analysis and thermogravimetric analysis; Visible, UV and infrared absorption. To accurately assess the sodium Azumolene content three different analytical methods (visible and UV spectrophotometry and high performance liquid chromatography) were developed and validated. All methods showed to be linear, accurate, precise and reliable. Azumolene has shown to be equipotent to dantrolene in the treatment and prevention of an MH crisis and the great advantage compared to dantrolene is better water solubility. This study has characterized the sodium azumolene and presents new analytical methods which have not been reported so far.Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fármacos e Médicamentos, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jaú, km1, Campus, CEP 14801-902, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fármacos e Médicamentos, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jaú, km1, Campus, CEP 14801-902, SP, BrasilUniversidade Estadual Paulista (Unesp)Corrêa, Josilene Chaves Ruela [UNESP]Hiene, Marcelo Augusto Cavaretti [UNESP]Salgado, Hérida Regina Nunes [UNESP]2016-01-28T16:56:27Z2016-01-28T16:56:27Z2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-6application/pdfhttp://dx.doi.org/10.4172/2155-9872.1000177Journal of Analytical & Bioanalytical Techniques, v. 5, n. 1, p. 1-6, 2013.2155-9872http://hdl.handle.net/11449/13374510.4172/2155-9872.1000177ISSN2155-9872-2013-05-01-01-06.pdf603621858764802898817202915717749543471795910202Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Analytical & Bioanalytical Techniquesinfo:eu-repo/semantics/openAccess2024-06-24T13:45:28Zoai:repositorio.unesp.br:11449/133745Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:10:52.562330Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia
title Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia
spellingShingle Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia
Corrêa, Josilene Chaves Ruela [UNESP]
Malignant hyperthermia
Sodium azumolene
UV-VIS
Spectrophotometry
Liquid chromatography
Quality control
title_short Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia
title_full Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia
title_fullStr Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia
title_full_unstemmed Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia
title_sort Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia
author Corrêa, Josilene Chaves Ruela [UNESP]
author_facet Corrêa, Josilene Chaves Ruela [UNESP]
Hiene, Marcelo Augusto Cavaretti [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
author_role author
author2 Hiene, Marcelo Augusto Cavaretti [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Corrêa, Josilene Chaves Ruela [UNESP]
Hiene, Marcelo Augusto Cavaretti [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
dc.subject.por.fl_str_mv Malignant hyperthermia
Sodium azumolene
UV-VIS
Spectrophotometry
Liquid chromatography
Quality control
topic Malignant hyperthermia
Sodium azumolene
UV-VIS
Spectrophotometry
Liquid chromatography
Quality control
description Sodium azumolene is a drug designed to fight Malignant Hyperthermia (MH), which is characterized by genetic predisposition and triggered by the use of inhalational anesthetics. This drug is shown as a water-soluble analogue of dantrolene sodium, 30-folds more water soluble, which gives advantages for its emergency use. To our knowledge there is no analytical method for sodium zaumolene raw material or dosage form published so far. The objective of the present investigation was to develop and validate analytical methods to achieve sodium azumolene chemical identification and quantification. The sodium azumolene was characterized regarding its thermal behavior, by differential thermal analysis and thermogravimetric analysis; Visible, UV and infrared absorption. To accurately assess the sodium Azumolene content three different analytical methods (visible and UV spectrophotometry and high performance liquid chromatography) were developed and validated. All methods showed to be linear, accurate, precise and reliable. Azumolene has shown to be equipotent to dantrolene in the treatment and prevention of an MH crisis and the great advantage compared to dantrolene is better water solubility. This study has characterized the sodium azumolene and presents new analytical methods which have not been reported so far.
publishDate 2013
dc.date.none.fl_str_mv 2013
2016-01-28T16:56:27Z
2016-01-28T16:56:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.4172/2155-9872.1000177
Journal of Analytical & Bioanalytical Techniques, v. 5, n. 1, p. 1-6, 2013.
2155-9872
http://hdl.handle.net/11449/133745
10.4172/2155-9872.1000177
ISSN2155-9872-2013-05-01-01-06.pdf
6036218587648028
9881720291571774
9543471795910202
url http://dx.doi.org/10.4172/2155-9872.1000177
http://hdl.handle.net/11449/133745
identifier_str_mv Journal of Analytical & Bioanalytical Techniques, v. 5, n. 1, p. 1-6, 2013.
2155-9872
10.4172/2155-9872.1000177
ISSN2155-9872-2013-05-01-01-06.pdf
6036218587648028
9881720291571774
9543471795910202
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Analytical & Bioanalytical Techniques
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-6
application/pdf
dc.source.none.fl_str_mv Currículo Lattes
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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