Avaliação do reparo ósseo comparando tamanhos diferentes de defeitos crítico: análise histológica, histométrica e imuno-histoquímica

• Autor(a) principal: Ramires, Guilherme André Del' Arco [UNESP]
• Data de Publicação: 2016
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/155196; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-05-03/000880711.pdf
• topic: Materiais biomédicos; Regeneração óssea; Imunohistoquímica; Histologia; Colágeno; Biomedical materials

Currently, there is controversy in the literature about the most appropriate size and location of a calvarial defect to be considered as critical. Therefore, the aim of this study was analyze through histometric, histologic and immunohistochemistry the ideal size bone defects for critical cavities comparing 5 and 8mm defects in skulls of mice. And yet assessed whether these critics said defects are influenced in the repair when associated with one porcine collagen membrane. It evaluated 5 and 8mm defects on periods 7, 30 and 60 days in rats with and without guided bone regeneration (Bio-Gide® - Geistlich Wolhusen, Switzerland). As a histometric result we noted partial repair analysis in all the groups with the highest percentage of new bone formation in the treated biomaterial. We conclude that both 5mm and 8mm defects can be considered critical because it does not repair spontaneously without medical intervention, and the choice of which appropriate size will depend on the material being studied, and although the porcine collagen membrane helps in the repair of the bone defect, but it is not enough to fix the entire length of the bone defect in both dimensions