Longitudinal Shortening of the Left Ventricle by Cine-CMR for Assessment of Diastolic Function in Patients with Aortic Valve Disease

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Sergio Marrone
Data de Publicação: 2019
Outros Autores: Azevedo Filho, Clerio Francisco De, Sampaio, Roney, Tarasoutchi, Flávio, Grinberg, Max, Kalil-filho, Roberto, Rochitte, Carlos Eduardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.5935/abc.20190193
http://hdl.handle.net/11449/183707
Resumo: AbstractBackground: Diastolic dysfunction, commonly evaluated by echocardiography, is an important early finding in many cardiomyopathies. Cardiac magnetic resonance (CMR) often requires specialized sequences that extends the test time. Recently, feature-tracking imaging has been made available, but still requires expensive software and lacks clinical validation.Objective: To assess diastolic function in patients with aortic valve disease (AVD) and compare it with normal controls by evaluating left ventricular (LV) longitudinal displacement by CMR.Methods: We compared 26 AVD patients with 19 normal controls. Diastolic function was evaluated as LV longitudinal displacement in 4-chamber view cine-CMR images using steady state free precession (SSFP) sequence during the entire cardiac cycle with temporal resolution < 50 ms. The resulting plot of atrioventricular junction (AVJ) position versus time generated variables of AVJ motion. Significance level of p < 0.05 was used.Results: Maximum longitudinal displacement (0.12 vs. 0.17 cm), maximum velocity during early diastole (MVED, 0.6 vs. 1.4s-1), slope of the best-fit line of displacement in diastasis (VDS, 0.22 vs. 0.03s-1), and VDS/MVED ratio (0.35 vs. 0.02) were significantly reduced in AVD patients compared with controls, respectively. Aortic regurgitation showed significantly worse longitudinal LV shortening compared with aortic stenosis. Higher LV mass indicated worse diastolic dysfunction.Conclusions: A simple linear measurement detected significant differences on LV diastolic function between AVD patients and controls. LV mass was the only independent predictor of diastolic dysfunction in these patients. This method can help in the evaluation of diastolic dysfunction, improving cardiomyopathy detection by CMR, without prolonging exam time or depending on expensive software.
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spelling Longitudinal Shortening of the Left Ventricle by Cine-CMR for Assessment of Diastolic Function in Patients with Aortic Valve DiseaseEncurtamento Longitudinal do Ventrículo Esquerdo por Cine-RMC para Avaliação da Função Diastólica em Pacientes com Doença Valvar AórticaCardiovascular Diseases/mortalityCardiomyopathy, Hypertrophic/complicationsDiagnostic ImagingEchocardiographyMagnetic Resonance SpectroscopyHeart FailureAortic Valve InsufficiencyDoenças Cardiovasculares/mortalidadeCardiomiopatia Hipertrófica/complicaçõesDiagnóstico por ImagemEcocardiografiaEspectroscopia por Ressonância MagnéticaInsuficiência CardíacaInsuficiência da Valva AórticaAbstractBackground: Diastolic dysfunction, commonly evaluated by echocardiography, is an important early finding in many cardiomyopathies. Cardiac magnetic resonance (CMR) often requires specialized sequences that extends the test time. Recently, feature-tracking imaging has been made available, but still requires expensive software and lacks clinical validation.Objective: To assess diastolic function in patients with aortic valve disease (AVD) and compare it with normal controls by evaluating left ventricular (LV) longitudinal displacement by CMR.Methods: We compared 26 AVD patients with 19 normal controls. Diastolic function was evaluated as LV longitudinal displacement in 4-chamber view cine-CMR images using steady state free precession (SSFP) sequence during the entire cardiac cycle with temporal resolution < 50 ms. The resulting plot of atrioventricular junction (AVJ) position versus time generated variables of AVJ motion. Significance level of p < 0.05 was used.Results: Maximum longitudinal displacement (0.12 vs. 0.17 cm), maximum velocity during early diastole (MVED, 0.6 vs. 1.4s-1), slope of the best-fit line of displacement in diastasis (VDS, 0.22 vs. 0.03s-1), and VDS/MVED ratio (0.35 vs. 0.02) were significantly reduced in AVD patients compared with controls, respectively. Aortic regurgitation showed significantly worse longitudinal LV shortening compared with aortic stenosis. Higher LV mass indicated worse diastolic dysfunction.Conclusions: A simple linear measurement detected significant differences on LV diastolic function between AVD patients and controls. LV mass was the only independent predictor of diastolic dysfunction in these patients. This method can help in the evaluation of diastolic dysfunction, improving cardiomyopathy detection by CMR, without prolonging exam time or depending on expensive software.ResumoFundamentos: A disfunção diastólica, comumente avaliada por ecocardiografia, é um importante achado precoce na maioria das cardiomiopatias. A ressonância magnética cardíaca (RMC) frequentemente requer sequências específicas que prolongam o tempo de exame. Recentemente, métodos de imagens com monitoramento de dados (feature-tracking) foram desenvolvidos, mas ainda requerem softwares caros e carecem de validação clínica.Objetivos: Avaliar a função diastólica em pacientes com doença valvar aórtica (DVA) e compará-la a controles normais pela medida do deslocamento longitudinal do ventrículo esquerdo (VE) por RMC.Métodos: Nós comparamos 26 pacientes com DVA com 19 controles normais. A função diastólica foi avaliada como uma medida do deslocamento longitudinal do VE nas imagens de cine-RMC no plano quatro câmaras usando a sequência steady state free precession (SSFP) durante todo o ciclo cardíaco com resolução temporal < 50 ms. O gráfico resultante da posição da junção atrioventricular versus tempo gerou variáveis de movimento da junção atrioventricular. Utilizamos nível de significância de p < 0,005.Resultados: Deslocamento longitudinal máximo (0,12 vs. 0,17 cm), velocidade máxima em início de diástole (0,6 vs. 1,4s-1), velocidade máxima na diástase (0,22 vs. 0,03s-1) e a razão entre a velocidade máxima na diástase e a velocidade máxima em diástole inicial (0,35 vs. 0,02) foram significativamente menores nos pacientes com DVA em comparação aos controles normais, respectivamente. Pacientes com insuficiência aórtica apresentaram medidas de encurtamento longitudinal do VE significativamente piores em comparação aqueles com estenose aórtica. O aumento da massa ventricular esquerda indicou pior disfunção diastólica.Conclusões: Esta simples medida linear detectou diferenças significativas na função diastólica do VE entre pacientes com DVA e controles normais. A massa ventricular esquerda foi o único preditor independente de disfunção diastólica nesses pacientes. Este método pode auxiliar na avaliação da disfunção diastólica, melhorando a detecção de cardiomiopatias por RMC sem prolongar o tempo de exame ou depender de caros softwares.Universidade Estadual Paulista (UNESP)Universidade do Estado do Rio de Janeiro (UERJ)Universidade de São Paulo (USP) Instituto do Coração (InCor)Universidade Estadual Paulista (UNESP)Sociedade Brasileira de Cardiologia - SBCUniversidade Estadual Paulista (Unesp)Universidade do Estado do Rio de Janeiro (UERJ)Universidade de São Paulo (USP)Ribeiro, Sergio MarroneAzevedo Filho, Clerio Francisco DeSampaio, RoneyTarasoutchi, FlávioGrinberg, MaxKalil-filho, RobertoRochitte, Carlos Eduardo2019-10-03T17:31:17Z2019-10-03T17:31:17Z2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article-application/pdfhttp://dx.doi.org/10.5935/abc.20190193Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, n. ahead, p. -, 2019.0066-782Xhttp://hdl.handle.net/11449/18370710.5935/abc.20190193S0066-782X2019005018105S0066-782X2019005018105.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos Brasileiros de Cardiologiainfo:eu-repo/semantics/openAccess2023-12-05T06:19:45Zoai:repositorio.unesp.br:11449/183707Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:34:04.612711Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Longitudinal Shortening of the Left Ventricle by Cine-CMR for Assessment of Diastolic Function in Patients with Aortic Valve Disease
Encurtamento Longitudinal do Ventrículo Esquerdo por Cine-RMC para Avaliação da Função Diastólica em Pacientes com Doença Valvar Aórtica
title Longitudinal Shortening of the Left Ventricle by Cine-CMR for Assessment of Diastolic Function in Patients with Aortic Valve Disease
spellingShingle Longitudinal Shortening of the Left Ventricle by Cine-CMR for Assessment of Diastolic Function in Patients with Aortic Valve Disease
Ribeiro, Sergio Marrone
Cardiovascular Diseases/mortality
Cardiomyopathy, Hypertrophic/complications
Diagnostic Imaging
Echocardiography
Magnetic Resonance Spectroscopy
Heart Failure
Aortic Valve Insufficiency
Doenças Cardiovasculares/mortalidade
Cardiomiopatia Hipertrófica/complicações
Diagnóstico por Imagem
Ecocardiografia
Espectroscopia por Ressonância Magnética
Insuficiência Cardíaca
Insuficiência da Valva Aórtica
title_short Longitudinal Shortening of the Left Ventricle by Cine-CMR for Assessment of Diastolic Function in Patients with Aortic Valve Disease
title_full Longitudinal Shortening of the Left Ventricle by Cine-CMR for Assessment of Diastolic Function in Patients with Aortic Valve Disease
title_fullStr Longitudinal Shortening of the Left Ventricle by Cine-CMR for Assessment of Diastolic Function in Patients with Aortic Valve Disease
title_full_unstemmed Longitudinal Shortening of the Left Ventricle by Cine-CMR for Assessment of Diastolic Function in Patients with Aortic Valve Disease
title_sort Longitudinal Shortening of the Left Ventricle by Cine-CMR for Assessment of Diastolic Function in Patients with Aortic Valve Disease
author Ribeiro, Sergio Marrone
author_facet Ribeiro, Sergio Marrone
Azevedo Filho, Clerio Francisco De
Sampaio, Roney
Tarasoutchi, Flávio
Grinberg, Max
Kalil-filho, Roberto
Rochitte, Carlos Eduardo
author_role author
author2 Azevedo Filho, Clerio Francisco De
Sampaio, Roney
Tarasoutchi, Flávio
Grinberg, Max
Kalil-filho, Roberto
Rochitte, Carlos Eduardo
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade do Estado do Rio de Janeiro (UERJ)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Ribeiro, Sergio Marrone
Azevedo Filho, Clerio Francisco De
Sampaio, Roney
Tarasoutchi, Flávio
Grinberg, Max
Kalil-filho, Roberto
Rochitte, Carlos Eduardo
dc.subject.por.fl_str_mv Cardiovascular Diseases/mortality
Cardiomyopathy, Hypertrophic/complications
Diagnostic Imaging
Echocardiography
Magnetic Resonance Spectroscopy
Heart Failure
Aortic Valve Insufficiency
Doenças Cardiovasculares/mortalidade
Cardiomiopatia Hipertrófica/complicações
Diagnóstico por Imagem
Ecocardiografia
Espectroscopia por Ressonância Magnética
Insuficiência Cardíaca
Insuficiência da Valva Aórtica
topic Cardiovascular Diseases/mortality
Cardiomyopathy, Hypertrophic/complications
Diagnostic Imaging
Echocardiography
Magnetic Resonance Spectroscopy
Heart Failure
Aortic Valve Insufficiency
Doenças Cardiovasculares/mortalidade
Cardiomiopatia Hipertrófica/complicações
Diagnóstico por Imagem
Ecocardiografia
Espectroscopia por Ressonância Magnética
Insuficiência Cardíaca
Insuficiência da Valva Aórtica
description AbstractBackground: Diastolic dysfunction, commonly evaluated by echocardiography, is an important early finding in many cardiomyopathies. Cardiac magnetic resonance (CMR) often requires specialized sequences that extends the test time. Recently, feature-tracking imaging has been made available, but still requires expensive software and lacks clinical validation.Objective: To assess diastolic function in patients with aortic valve disease (AVD) and compare it with normal controls by evaluating left ventricular (LV) longitudinal displacement by CMR.Methods: We compared 26 AVD patients with 19 normal controls. Diastolic function was evaluated as LV longitudinal displacement in 4-chamber view cine-CMR images using steady state free precession (SSFP) sequence during the entire cardiac cycle with temporal resolution < 50 ms. The resulting plot of atrioventricular junction (AVJ) position versus time generated variables of AVJ motion. Significance level of p < 0.05 was used.Results: Maximum longitudinal displacement (0.12 vs. 0.17 cm), maximum velocity during early diastole (MVED, 0.6 vs. 1.4s-1), slope of the best-fit line of displacement in diastasis (VDS, 0.22 vs. 0.03s-1), and VDS/MVED ratio (0.35 vs. 0.02) were significantly reduced in AVD patients compared with controls, respectively. Aortic regurgitation showed significantly worse longitudinal LV shortening compared with aortic stenosis. Higher LV mass indicated worse diastolic dysfunction.Conclusions: A simple linear measurement detected significant differences on LV diastolic function between AVD patients and controls. LV mass was the only independent predictor of diastolic dysfunction in these patients. This method can help in the evaluation of diastolic dysfunction, improving cardiomyopathy detection by CMR, without prolonging exam time or depending on expensive software.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-03T17:31:17Z
2019-10-03T17:31:17Z
2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5935/abc.20190193
Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, n. ahead, p. -, 2019.
0066-782X
http://hdl.handle.net/11449/183707
10.5935/abc.20190193
S0066-782X2019005018105
S0066-782X2019005018105.pdf
url http://dx.doi.org/10.5935/abc.20190193
http://hdl.handle.net/11449/183707
identifier_str_mv Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, n. ahead, p. -, 2019.
0066-782X
10.5935/abc.20190193
S0066-782X2019005018105
S0066-782X2019005018105.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Cardiologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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