Músculo esquelético, insuficiência cardíaca crônica e o papel do exercício

• Autor(a) principal: Yamada, Andre Katayama
• Data de Publicação: 2009
• Outros Autores: Voltarelli, Vanessa Azevedo, Voltarelli, Fabricio Azevedo [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.periodicos.rc.biblioteca.unesp.br/index.php/motriz/article/view/2079; http://hdl.handle.net/11449/40865
• topic: Chronic Heart Failure; Skeletal Muscle; Physical Exercise; Therapy

Patients with chronic heart failure (CHF) show metabolic, hemodynamic and skeletal muscle alterations, which decrease the life expectancy. These alterations are attributed to several factors. The focus of this review was to approach the questions related to physiological, metabolic, morphological and molecular alterations which affect the muscular system of these patients. Later, it was discussed the benefits of physical exercise to this syndrome as well as the pharmacological interventions, which are in investigation aiming the treatment of the same. Some muscle alterations are already described on the literature. For example, the more predominance of type II fibers, lower oxidative enzymatic activity, muscle atrophy and elevated concentration of cytokines that affect the muscle integrity. Thus, further studies involving cellular and molecular mechanisms of skeletal muscle in order to create strategies for prevention and treatment for patients with CHF are required