Coating of surgical masks with quaternized chitosan aiming at inactivating coronavirus and antibacterial activity

• Autor(a) principal: Kerwald, Jonas
• Data de Publicação: 2023
• Outros Autores: de Moura Junior, Celso Fidelis, Freitas, Emanuelle Dantas, Ochi, Deise, Sorrechia, Rodrigo [UNESP], Pietro, Rosemeire Cristina Linhari Rodrigues [UNESP], Beppu, Marisa Masumi
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.carpta.2023.100315; http://hdl.handle.net/11449/248879
• topic: Chitosan; Coating; Coronavirus; Inactivation; Quaternization

SARS-CoV-2 caused a global pandemic with high transmission rates, even with widespread vaccination. In addition to isolation and prevention measures, it is important to find new solutions to inactivate the virus and prevent its viability on surfaces, such as clothing and face masks. Chitosan derivatives, with their antibacterial activity, biocompatibility, and non-toxicity, are a promising option for coating these components with virucidal materials. N-(2-hydroxypropryl)-3-trimethylammonium chloride, a quaternized chitosan derivative with degrees of substitution ranging from 59 to 93%, was synthesized. This derivative was used to coat cotton and polypropylene fabrics, such as face masks, without visibly affecting their morphology or filtering capacity. In vitro tests demonstrated that the coatings produced had high antiviral activity against coronavirus, with efficacy up to 99.99%, and were also bactericidal against E. coli and S. aureus. These results show that quaternized chitosan derivatives have great potential to be used as virucidal coatings, helping to prevent the spread of SARS-Cov-2 and other pathogens on surfaces, which can even be useful for the quick development of solutions for future pandemics.