Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedentários submetidos à exercício físico
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/99872 |
Resumo: | Physical inactivity is a public health problem and one of the greatest evils of modern society. Biggest part of the sedentary population practice physical activity sporadically. It is well established that the excess of physical exercise in or non-conditioned people causes oxidative stress and muscle damage. The present study tested the hypothesis that a single session of physical exercise can cause oxidative stress and muscle damage in sedentary rats. Additively, the antioxidant effect of the polyphenol resveratrol (RV) was evaluated, and its ability to attenuate oxidative stress and muscle damage caused by physical activity. For this, 40 sedentary adults rats (Rattus norvegicus Albinus, Wistar) were randomly subjected or not to 90 minutes of swimming, with and without treatment with RV (100mg/kg/14days): N-RV- (n=10) group maintained at rest and not treated with RV, N-RV+ (n=10) group maintained at rest and treated with RV, N+RV- (n=10) group subjected to physical exercise of swimming not treated with RV and N+RV+ (n=10) group submitted to physical exercise of swimming and treated with RV. In sedentary rats, physical activity of swimming promoted oxidative stress (observed by increased lipid peroxidation and decreased total antioxidant capacity of plasma) and significant increase in plasma activity of creatine kinase (CK) and lactate dehydrogenase (LDH). The RV treatment decreased lipid peroxidation and activity of the markers of muscle injury (CK and LDH) in sedentary rats submitted to swimming. This is one of the first evidence that a single session of physical exercise can cause oxidative stress in sedentary individuals and that the RV can be an alternative to alleviate muscle injury caused by this stress |
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Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedentários submetidos à exercício físicoAntioxidantesNataçãoStress oxidativoRatoExercícios físicos aquáticosResveratrolPhysical inactivity is a public health problem and one of the greatest evils of modern society. Biggest part of the sedentary population practice physical activity sporadically. It is well established that the excess of physical exercise in or non-conditioned people causes oxidative stress and muscle damage. The present study tested the hypothesis that a single session of physical exercise can cause oxidative stress and muscle damage in sedentary rats. Additively, the antioxidant effect of the polyphenol resveratrol (RV) was evaluated, and its ability to attenuate oxidative stress and muscle damage caused by physical activity. For this, 40 sedentary adults rats (Rattus norvegicus Albinus, Wistar) were randomly subjected or not to 90 minutes of swimming, with and without treatment with RV (100mg/kg/14days): N-RV- (n=10) group maintained at rest and not treated with RV, N-RV+ (n=10) group maintained at rest and treated with RV, N+RV- (n=10) group subjected to physical exercise of swimming not treated with RV and N+RV+ (n=10) group submitted to physical exercise of swimming and treated with RV. In sedentary rats, physical activity of swimming promoted oxidative stress (observed by increased lipid peroxidation and decreased total antioxidant capacity of plasma) and significant increase in plasma activity of creatine kinase (CK) and lactate dehydrogenase (LDH). The RV treatment decreased lipid peroxidation and activity of the markers of muscle injury (CK and LDH) in sedentary rats submitted to swimming. This is one of the first evidence that a single session of physical exercise can cause oxidative stress in sedentary individuals and that the RV can be an alternative to alleviate muscle injury caused by this stressUniversidade Estadual Paulista (Unesp)Louzada, Mário Jefferson Quirino [UNESP]Ciarlini, Paulo Cesar [UNESP]Universidade Estadual Paulista (Unesp)Narciso, Luis Gustavo [UNESP]2014-06-11T19:30:23Z2014-06-11T19:30:23Z2013-12-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis64 f.application/pdfNARCISO, Luis Gustavo. Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedendários submetidos à exercício físico: Luis Gustavo Narciso. 64 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária de Araçatuba, 2013.http://hdl.handle.net/11449/99872000743692000743692.pdf33004021075P8292564919505233936139400182995000000-0003-1480-5208Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2023-10-20T06:06:45Zoai:repositorio.unesp.br:11449/99872Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:26:08.168728Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedentários submetidos à exercício físico |
title |
Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedentários submetidos à exercício físico |
spellingShingle |
Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedentários submetidos à exercício físico Narciso, Luis Gustavo [UNESP] Antioxidantes Natação Stress oxidativo Rato Exercícios físicos aquáticos Resveratrol |
title_short |
Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedentários submetidos à exercício físico |
title_full |
Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedentários submetidos à exercício físico |
title_fullStr |
Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedentários submetidos à exercício físico |
title_full_unstemmed |
Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedentários submetidos à exercício físico |
title_sort |
Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedentários submetidos à exercício físico |
author |
Narciso, Luis Gustavo [UNESP] |
author_facet |
Narciso, Luis Gustavo [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Louzada, Mário Jefferson Quirino [UNESP] Ciarlini, Paulo Cesar [UNESP] Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Narciso, Luis Gustavo [UNESP] |
dc.subject.por.fl_str_mv |
Antioxidantes Natação Stress oxidativo Rato Exercícios físicos aquáticos Resveratrol |
topic |
Antioxidantes Natação Stress oxidativo Rato Exercícios físicos aquáticos Resveratrol |
description |
Physical inactivity is a public health problem and one of the greatest evils of modern society. Biggest part of the sedentary population practice physical activity sporadically. It is well established that the excess of physical exercise in or non-conditioned people causes oxidative stress and muscle damage. The present study tested the hypothesis that a single session of physical exercise can cause oxidative stress and muscle damage in sedentary rats. Additively, the antioxidant effect of the polyphenol resveratrol (RV) was evaluated, and its ability to attenuate oxidative stress and muscle damage caused by physical activity. For this, 40 sedentary adults rats (Rattus norvegicus Albinus, Wistar) were randomly subjected or not to 90 minutes of swimming, with and without treatment with RV (100mg/kg/14days): N-RV- (n=10) group maintained at rest and not treated with RV, N-RV+ (n=10) group maintained at rest and treated with RV, N+RV- (n=10) group subjected to physical exercise of swimming not treated with RV and N+RV+ (n=10) group submitted to physical exercise of swimming and treated with RV. In sedentary rats, physical activity of swimming promoted oxidative stress (observed by increased lipid peroxidation and decreased total antioxidant capacity of plasma) and significant increase in plasma activity of creatine kinase (CK) and lactate dehydrogenase (LDH). The RV treatment decreased lipid peroxidation and activity of the markers of muscle injury (CK and LDH) in sedentary rats submitted to swimming. This is one of the first evidence that a single session of physical exercise can cause oxidative stress in sedentary individuals and that the RV can be an alternative to alleviate muscle injury caused by this stress |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-10 2014-06-11T19:30:23Z 2014-06-11T19:30:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
NARCISO, Luis Gustavo. Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedendários submetidos à exercício físico: Luis Gustavo Narciso. 64 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária de Araçatuba, 2013. http://hdl.handle.net/11449/99872 000743692 000743692.pdf 33004021075P8 2925649195052339 3613940018299500 0000-0003-1480-5208 |
identifier_str_mv |
NARCISO, Luis Gustavo. Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedendários submetidos à exercício físico: Luis Gustavo Narciso. 64 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária de Araçatuba, 2013. 000743692 000743692.pdf 33004021075P8 2925649195052339 3613940018299500 0000-0003-1480-5208 |
url |
http://hdl.handle.net/11449/99872 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
64 f. application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.source.none.fl_str_mv |
Aleph reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128513003225088 |