Impact of early fructose intake on metabolic profile and aerobic capacity of rats
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1476-511X-10-3 http://hdl.handle.net/11449/20895 |
Resumo: | Background: Metabolic syndrome is a disease that today affects millions of people around the world. Therefore, it is of great interest to implement more effective procedures for preventing and treating this disease. In search of a suitable experimental model to study the role of exercise in prevention and treatment of metabolic syndrome, this study examined the metabolic profile and the aerobic capacity of rats kept early in life on a fructose-rich diet, a substrate that has been associated with metabolic syndrome.Methods: We used adult female Wistar rats fed during pregnancy and lactation with two diets: balanced or fructose-rich 60%. During breastfeeding, the pups were distributed in small (4/mother) or adequate (8/mother) litters. At 90 days of age, they were analyzed with respect to: glucose tolerance, peripheral insulin sensitivity, aerobic capacity and serum glucose, insulin, triglycerides, total cholesterol, LDL cholesterol and HDL cholesterol concentrations as well as measures of glycogen synthesis and glucose oxidation by the soleus muscle.Results: It was found that the fructose rich diet led the animals to insulin resistance. The fructose fed rats kept in small litters also showed dyslipidemia, with increased serum concentrations of total cholesterol and triglycerides.Conclusion: Neither the aerobic capacity nor the glucose oxidation rates by the skeletal muscle were altered by fructose-rich diet, indicating that the animal model evaluated is potentially interesting for the study of the role of exercise in metabolic syndrome. |
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Impact of early fructose intake on metabolic profile and aerobic capacity of ratsBackground: Metabolic syndrome is a disease that today affects millions of people around the world. Therefore, it is of great interest to implement more effective procedures for preventing and treating this disease. In search of a suitable experimental model to study the role of exercise in prevention and treatment of metabolic syndrome, this study examined the metabolic profile and the aerobic capacity of rats kept early in life on a fructose-rich diet, a substrate that has been associated with metabolic syndrome.Methods: We used adult female Wistar rats fed during pregnancy and lactation with two diets: balanced or fructose-rich 60%. During breastfeeding, the pups were distributed in small (4/mother) or adequate (8/mother) litters. At 90 days of age, they were analyzed with respect to: glucose tolerance, peripheral insulin sensitivity, aerobic capacity and serum glucose, insulin, triglycerides, total cholesterol, LDL cholesterol and HDL cholesterol concentrations as well as measures of glycogen synthesis and glucose oxidation by the soleus muscle.Results: It was found that the fructose rich diet led the animals to insulin resistance. The fructose fed rats kept in small litters also showed dyslipidemia, with increased serum concentrations of total cholesterol and triglycerides.Conclusion: Neither the aerobic capacity nor the glucose oxidation rates by the skeletal muscle were altered by fructose-rich diet, indicating that the animal model evaluated is potentially interesting for the study of the role of exercise in metabolic syndrome.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)São Paulo State Univ UNESP, Dept Phys Educ, BR-13506900 São Paulo, BrazilSão Paulo State Univ UNESP, Dept Phys Educ, BR-13506900 São Paulo, BrazilBiomed Central Ltd.Universidade Estadual Paulista (Unesp)Ghezzi, Ana C. [UNESP]Cambri, Lucieli T. [UNESP]Ribeiro, Carla [UNESP]Botezelli, Jose D. [UNESP]Mello, Maria A. R. [UNESP]2013-09-30T18:49:23Z2014-05-20T13:58:48Z2013-09-30T18:49:23Z2014-05-20T13:58:48Z2011-01-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://dx.doi.org/10.1186/1476-511X-10-3Lipids In Health and Disease. London: Biomed Central Ltd., v. 10, p. 8, 2011.1476-511Xhttp://hdl.handle.net/11449/2089510.1186/1476-511X-10-3WOS:000286528500001WOS000286528500001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLipids in Health and Disease2.663info:eu-repo/semantics/openAccess2023-11-08T06:14:23Zoai:repositorio.unesp.br:11449/20895Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-08T06:14:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Impact of early fructose intake on metabolic profile and aerobic capacity of rats |
title |
Impact of early fructose intake on metabolic profile and aerobic capacity of rats |
spellingShingle |
Impact of early fructose intake on metabolic profile and aerobic capacity of rats Ghezzi, Ana C. [UNESP] |
title_short |
Impact of early fructose intake on metabolic profile and aerobic capacity of rats |
title_full |
Impact of early fructose intake on metabolic profile and aerobic capacity of rats |
title_fullStr |
Impact of early fructose intake on metabolic profile and aerobic capacity of rats |
title_full_unstemmed |
Impact of early fructose intake on metabolic profile and aerobic capacity of rats |
title_sort |
Impact of early fructose intake on metabolic profile and aerobic capacity of rats |
author |
Ghezzi, Ana C. [UNESP] |
author_facet |
Ghezzi, Ana C. [UNESP] Cambri, Lucieli T. [UNESP] Ribeiro, Carla [UNESP] Botezelli, Jose D. [UNESP] Mello, Maria A. R. [UNESP] |
author_role |
author |
author2 |
Cambri, Lucieli T. [UNESP] Ribeiro, Carla [UNESP] Botezelli, Jose D. [UNESP] Mello, Maria A. R. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ghezzi, Ana C. [UNESP] Cambri, Lucieli T. [UNESP] Ribeiro, Carla [UNESP] Botezelli, Jose D. [UNESP] Mello, Maria A. R. [UNESP] |
description |
Background: Metabolic syndrome is a disease that today affects millions of people around the world. Therefore, it is of great interest to implement more effective procedures for preventing and treating this disease. In search of a suitable experimental model to study the role of exercise in prevention and treatment of metabolic syndrome, this study examined the metabolic profile and the aerobic capacity of rats kept early in life on a fructose-rich diet, a substrate that has been associated with metabolic syndrome.Methods: We used adult female Wistar rats fed during pregnancy and lactation with two diets: balanced or fructose-rich 60%. During breastfeeding, the pups were distributed in small (4/mother) or adequate (8/mother) litters. At 90 days of age, they were analyzed with respect to: glucose tolerance, peripheral insulin sensitivity, aerobic capacity and serum glucose, insulin, triglycerides, total cholesterol, LDL cholesterol and HDL cholesterol concentrations as well as measures of glycogen synthesis and glucose oxidation by the soleus muscle.Results: It was found that the fructose rich diet led the animals to insulin resistance. The fructose fed rats kept in small litters also showed dyslipidemia, with increased serum concentrations of total cholesterol and triglycerides.Conclusion: Neither the aerobic capacity nor the glucose oxidation rates by the skeletal muscle were altered by fructose-rich diet, indicating that the animal model evaluated is potentially interesting for the study of the role of exercise in metabolic syndrome. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-11 2013-09-30T18:49:23Z 2013-09-30T18:49:23Z 2014-05-20T13:58:48Z 2014-05-20T13:58:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1476-511X-10-3 Lipids In Health and Disease. London: Biomed Central Ltd., v. 10, p. 8, 2011. 1476-511X http://hdl.handle.net/11449/20895 10.1186/1476-511X-10-3 WOS:000286528500001 WOS000286528500001.pdf |
url |
http://dx.doi.org/10.1186/1476-511X-10-3 http://hdl.handle.net/11449/20895 |
identifier_str_mv |
Lipids In Health and Disease. London: Biomed Central Ltd., v. 10, p. 8, 2011. 1476-511X 10.1186/1476-511X-10-3 WOS:000286528500001 WOS000286528500001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lipids in Health and Disease 2.663 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
8 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964864434667520 |