Relationship among short and long term of hypoinsulinemia-hyperglycemia, dermatophytosis, and immunobiology of mononuclear phagocytes
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2015/342345 http://hdl.handle.net/11449/172180 |
Resumo: | Dermatophytes are fungi responsible for causing superficial infections. In patients with diabetes mellitus (DM), dermatophytosis is usually more severe and recurrent. In the present study, we aimed to investigate the influence of short and long term hypoinsulinemia-hyperglycemia (HH) during experimental infection by Trichophyton mentagrophytes as well as alterations in the mononuclear phagocytes. Our results showed two distinct profiles of fungal outcome and immune response. Short term HH induced a discrete impaired proinflammatory response by peritoneal adherent cells (PAC) and a delayed fungal clearance. Moreover, long term HH mice showed low and persistent fungal load and a marked reduction in the production of TNF-α by PAC. Furthermore, while the inoculation of TM in non-HH mice triggered high influx of Gr1+ monocytes into the peripheral blood, long term HH mice showed low percentage of these cells. Thus, our results demonstrate that the time of exposure of HH interferes with the TM infection outcome as well as the immunobiology of mononuclear phagocytes, including fresh monocyte recruitment from bone marrow and PAC activity. |
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Relationship among short and long term of hypoinsulinemia-hyperglycemia, dermatophytosis, and immunobiology of mononuclear phagocytesDermatophytes are fungi responsible for causing superficial infections. In patients with diabetes mellitus (DM), dermatophytosis is usually more severe and recurrent. In the present study, we aimed to investigate the influence of short and long term hypoinsulinemia-hyperglycemia (HH) during experimental infection by Trichophyton mentagrophytes as well as alterations in the mononuclear phagocytes. Our results showed two distinct profiles of fungal outcome and immune response. Short term HH induced a discrete impaired proinflammatory response by peritoneal adherent cells (PAC) and a delayed fungal clearance. Moreover, long term HH mice showed low and persistent fungal load and a marked reduction in the production of TNF-α by PAC. Furthermore, while the inoculation of TM in non-HH mice triggered high influx of Gr1+ monocytes into the peripheral blood, long term HH mice showed low percentage of these cells. Thus, our results demonstrate that the time of exposure of HH interferes with the TM infection outcome as well as the immunobiology of mononuclear phagocytes, including fresh monocyte recruitment from bone marrow and PAC activity.Department of Biological Sciences School of Sciences Universidade Estadual Paulista (UNESP)Department of Microbiology and Immunology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)Department of Clinical Toxicological and Bromatological Analysis School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP)Botucatu Blood Center Universidade Estadual Paulista (UNESP)Department of Biological Sciences School of Sciences Universidade Estadual Paulista (UNESP)Department of Microbiology and Immunology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)Botucatu Blood Center Universidade Estadual Paulista (UNESP)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Fraga-Silva, Thais F. C. [UNESP]Marchetti, Camila M. [UNESP]Mimura, Luiza A. N. [UNESP]Locachevic, Gisele A.Golim, Márjorie A. [UNESP]Venturini, James [UNESP]Arruda, Maria S. P. [UNESP]2018-12-11T16:59:03Z2018-12-11T16:59:03Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2015/342345Mediators of Inflammation, v. 2015.1466-18610962-9351http://hdl.handle.net/11449/17218010.1155/2015/3423452-s2.0-849462257802-s2.0-84946225780.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMediators of Inflammation1,3701,370info:eu-repo/semantics/openAccess2024-01-04T06:26:59Zoai:repositorio.unesp.br:11449/172180Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:07:42.073079Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Relationship among short and long term of hypoinsulinemia-hyperglycemia, dermatophytosis, and immunobiology of mononuclear phagocytes |
title |
Relationship among short and long term of hypoinsulinemia-hyperglycemia, dermatophytosis, and immunobiology of mononuclear phagocytes |
spellingShingle |
Relationship among short and long term of hypoinsulinemia-hyperglycemia, dermatophytosis, and immunobiology of mononuclear phagocytes Fraga-Silva, Thais F. C. [UNESP] |
title_short |
Relationship among short and long term of hypoinsulinemia-hyperglycemia, dermatophytosis, and immunobiology of mononuclear phagocytes |
title_full |
Relationship among short and long term of hypoinsulinemia-hyperglycemia, dermatophytosis, and immunobiology of mononuclear phagocytes |
title_fullStr |
Relationship among short and long term of hypoinsulinemia-hyperglycemia, dermatophytosis, and immunobiology of mononuclear phagocytes |
title_full_unstemmed |
Relationship among short and long term of hypoinsulinemia-hyperglycemia, dermatophytosis, and immunobiology of mononuclear phagocytes |
title_sort |
Relationship among short and long term of hypoinsulinemia-hyperglycemia, dermatophytosis, and immunobiology of mononuclear phagocytes |
author |
Fraga-Silva, Thais F. C. [UNESP] |
author_facet |
Fraga-Silva, Thais F. C. [UNESP] Marchetti, Camila M. [UNESP] Mimura, Luiza A. N. [UNESP] Locachevic, Gisele A. Golim, Márjorie A. [UNESP] Venturini, James [UNESP] Arruda, Maria S. P. [UNESP] |
author_role |
author |
author2 |
Marchetti, Camila M. [UNESP] Mimura, Luiza A. N. [UNESP] Locachevic, Gisele A. Golim, Márjorie A. [UNESP] Venturini, James [UNESP] Arruda, Maria S. P. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Fraga-Silva, Thais F. C. [UNESP] Marchetti, Camila M. [UNESP] Mimura, Luiza A. N. [UNESP] Locachevic, Gisele A. Golim, Márjorie A. [UNESP] Venturini, James [UNESP] Arruda, Maria S. P. [UNESP] |
description |
Dermatophytes are fungi responsible for causing superficial infections. In patients with diabetes mellitus (DM), dermatophytosis is usually more severe and recurrent. In the present study, we aimed to investigate the influence of short and long term hypoinsulinemia-hyperglycemia (HH) during experimental infection by Trichophyton mentagrophytes as well as alterations in the mononuclear phagocytes. Our results showed two distinct profiles of fungal outcome and immune response. Short term HH induced a discrete impaired proinflammatory response by peritoneal adherent cells (PAC) and a delayed fungal clearance. Moreover, long term HH mice showed low and persistent fungal load and a marked reduction in the production of TNF-α by PAC. Furthermore, while the inoculation of TM in non-HH mice triggered high influx of Gr1+ monocytes into the peripheral blood, long term HH mice showed low percentage of these cells. Thus, our results demonstrate that the time of exposure of HH interferes with the TM infection outcome as well as the immunobiology of mononuclear phagocytes, including fresh monocyte recruitment from bone marrow and PAC activity. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 2018-12-11T16:59:03Z 2018-12-11T16:59:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2015/342345 Mediators of Inflammation, v. 2015. 1466-1861 0962-9351 http://hdl.handle.net/11449/172180 10.1155/2015/342345 2-s2.0-84946225780 2-s2.0-84946225780.pdf |
url |
http://dx.doi.org/10.1155/2015/342345 http://hdl.handle.net/11449/172180 |
identifier_str_mv |
Mediators of Inflammation, v. 2015. 1466-1861 0962-9351 10.1155/2015/342345 2-s2.0-84946225780 2-s2.0-84946225780.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mediators of Inflammation 1,370 1,370 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129394597691392 |