Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats

Detalhes bibliográficos
Autor(a) principal: Silva Junior, Aurélio Rosa Da
Data de Publicação: 2018
Outros Autores: Semenoff Segundo, Alex, Semenoff, Tereza Aparecida Delle Vedove, Silva, Natalino Francisco Da, Caporossi, Cervantes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1807-2577.03718
http://hdl.handle.net/11449/157859
Resumo: AbstractIntroductionWith glutamine supplementation there is better performance in the body’s defense system.ObjectiveThe aim of this study was to analyze the effect of glutamine supplementation on ligand-induced periodontal disease in rats.Material and method48 selected male Wistar rats were divided into 4 groups (N = 12): control group (CG) including healthy animals receiving daily saline solution via gavage; glutamine group (GG) including healthy animals receiving oral glutamine supplementation by gavage at a dose of 1.5 g / kg / day; periodontitis group (PG) including animals with induced periodontal disease on both upper sides receiving daily saline solution via gavage; experimental group (EG) including animals with induced periodontal disease on both upper sides receiving daily glutamine via gavage at a dose of 1.5 g / kg / day. On the 30th day, all animals were euthanized by excess anesthetic.ResultIn the various analyses, the EG (116.63 ± 22.50 mm2) compared to the CG (82.32 ± 7.48 mm2) obtained a p<0.05. The PG (143.15 ± 35.24 mm2) compared to the EG group (116.63 ± 22.50 mm2 ) presented a p<0.05. The PG (143.15 ± 35.24 mm2) compared to the CG (82.32 ± 7.48 mm2) presented a p<0.05. The GG (118.09 ± 10.4 mm2) compared to the CG (82.32 ± 7.48 mm2) presented a p>0.05.ConclusionGlutamine supplementation associated with induced periodontal disease demonstrated a smaller amount of bone loss compared to the periodontitis group.
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spelling Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in ratsEfeito da ingestão de glutamina na progressão de periodontite induzida: estudo experimental em ratosDietary supplementsperiodontal diseasesproducts with antimicrobial actionSuplementos nutricionaisdoenças periodontaisprodutos com ação antimicrobianaAbstractIntroductionWith glutamine supplementation there is better performance in the body’s defense system.ObjectiveThe aim of this study was to analyze the effect of glutamine supplementation on ligand-induced periodontal disease in rats.Material and method48 selected male Wistar rats were divided into 4 groups (N = 12): control group (CG) including healthy animals receiving daily saline solution via gavage; glutamine group (GG) including healthy animals receiving oral glutamine supplementation by gavage at a dose of 1.5 g / kg / day; periodontitis group (PG) including animals with induced periodontal disease on both upper sides receiving daily saline solution via gavage; experimental group (EG) including animals with induced periodontal disease on both upper sides receiving daily glutamine via gavage at a dose of 1.5 g / kg / day. On the 30th day, all animals were euthanized by excess anesthetic.ResultIn the various analyses, the EG (116.63 ± 22.50 mm2) compared to the CG (82.32 ± 7.48 mm2) obtained a p<0.05. The PG (143.15 ± 35.24 mm2) compared to the EG group (116.63 ± 22.50 mm2 ) presented a p<0.05. The PG (143.15 ± 35.24 mm2) compared to the CG (82.32 ± 7.48 mm2) presented a p<0.05. The GG (118.09 ± 10.4 mm2) compared to the CG (82.32 ± 7.48 mm2) presented a p>0.05.ConclusionGlutamine supplementation associated with induced periodontal disease demonstrated a smaller amount of bone loss compared to the periodontitis group.ResumoIntroduçãoCom a suplementação de glutamina há um melhor desempenho no sistema de defesa do corpo.ObjetivoO objetivo deste estudo foi analisar o efeito da suplementação de glutamina na doença periodontal induzida por ligatura em ratos.Material e métodoForam selecionados 48 ratos machos da linhagem Wistar divididos em 4 grupos (N = 12): grupo controle (GC) incluindo animais saudaveis recebendo solução salina diariamente via gavagem; grupo glutamina (GG) incluindo animais saudaveis que receberam suplementação oral de glutamina por gavagem a uma dose de 1,5 g/kg/dia; grupo periodontite (GP) incluindo animais com doença periodontal induzida na maxila em ambos os lados recebendo solução salina diária via gavagem; grupo experimental (GE) incluindo animais com doença periodontal induzida na maxila nos dois lados recebendo glutamina diária via gavagem na dose de 1,5 g/kg/dia. No 30º dia, todos os animais foram eutanasiados por excesso de anestésico.ResultadoNas várias análises, o GE (116,63 ± 22,50 mm2) comparado ao GC (82,32 ± 7,48 mm2) obteve um p<0,05. O GP (143,15 ± 35,24 mm2) comparado ao grupo GE (116,63 ± 22,50 mm2) apresentou p<0,05. O GP (143,15 ± 35,24 mm2) comparado ao GC (82,32 ± 7,48 mm2) apresentou p<0,05. O GG (118,09 ± 10,4 mm2 ) comparado ao GC (82,32 ± 7,48 mm2) apresentou p>0,05.ConclusãoA suplementação de glutamina associada à doença periodontal induzida demonstrou uma menor perda óssea em comparação com o grupo periodontite.Universidade de CuiabáUniversidade Estadual Paulista Faculdade de Odontologia de AraçatubaUniversidade Federal de Mato GrossoUniversidade Estadual Paulista Faculdade de Odontologia de AraçatubaUniversidade Estadual Paulista Júlio de Mesquita FilhoUniversidade de CuiabáUniversidade Estadual Paulista (Unesp)Universidade Federal de Mato GrossoSilva Junior, Aurélio Rosa DaSemenoff Segundo, AlexSemenoff, Tereza Aparecida Delle VedoveSilva, Natalino Francisco DaCaporossi, Cervantes2018-11-12T17:27:15Z2018-11-12T17:27:15Z2018-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article119-123application/pdfhttp://dx.doi.org/10.1590/1807-2577.03718Revista de Odontologia da UNESP. Universidade Estadual Paulista Júlio de Mesquita Filho, v. 47, n. 2, p. 119-123, 2018.1807-2577http://hdl.handle.net/11449/15785910.1590/1807-2577.03718S1807-25772018000200119S1807-25772018000200119.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista de Odontologia da UNESPinfo:eu-repo/semantics/openAccess2023-10-06T06:01:44Zoai:repositorio.unesp.br:11449/157859Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:07:49.254110Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats
Efeito da ingestão de glutamina na progressão de periodontite induzida: estudo experimental em ratos
title Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats
spellingShingle Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats
Silva Junior, Aurélio Rosa Da
Dietary supplements
periodontal diseases
products with antimicrobial action
Suplementos nutricionais
doenças periodontais
produtos com ação antimicrobiana
title_short Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats
title_full Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats
title_fullStr Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats
title_full_unstemmed Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats
title_sort Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats
author Silva Junior, Aurélio Rosa Da
author_facet Silva Junior, Aurélio Rosa Da
Semenoff Segundo, Alex
Semenoff, Tereza Aparecida Delle Vedove
Silva, Natalino Francisco Da
Caporossi, Cervantes
author_role author
author2 Semenoff Segundo, Alex
Semenoff, Tereza Aparecida Delle Vedove
Silva, Natalino Francisco Da
Caporossi, Cervantes
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Cuiabá
Universidade Estadual Paulista (Unesp)
Universidade Federal de Mato Grosso
dc.contributor.author.fl_str_mv Silva Junior, Aurélio Rosa Da
Semenoff Segundo, Alex
Semenoff, Tereza Aparecida Delle Vedove
Silva, Natalino Francisco Da
Caporossi, Cervantes
dc.subject.por.fl_str_mv Dietary supplements
periodontal diseases
products with antimicrobial action
Suplementos nutricionais
doenças periodontais
produtos com ação antimicrobiana
topic Dietary supplements
periodontal diseases
products with antimicrobial action
Suplementos nutricionais
doenças periodontais
produtos com ação antimicrobiana
description AbstractIntroductionWith glutamine supplementation there is better performance in the body’s defense system.ObjectiveThe aim of this study was to analyze the effect of glutamine supplementation on ligand-induced periodontal disease in rats.Material and method48 selected male Wistar rats were divided into 4 groups (N = 12): control group (CG) including healthy animals receiving daily saline solution via gavage; glutamine group (GG) including healthy animals receiving oral glutamine supplementation by gavage at a dose of 1.5 g / kg / day; periodontitis group (PG) including animals with induced periodontal disease on both upper sides receiving daily saline solution via gavage; experimental group (EG) including animals with induced periodontal disease on both upper sides receiving daily glutamine via gavage at a dose of 1.5 g / kg / day. On the 30th day, all animals were euthanized by excess anesthetic.ResultIn the various analyses, the EG (116.63 ± 22.50 mm2) compared to the CG (82.32 ± 7.48 mm2) obtained a p<0.05. The PG (143.15 ± 35.24 mm2) compared to the EG group (116.63 ± 22.50 mm2 ) presented a p<0.05. The PG (143.15 ± 35.24 mm2) compared to the CG (82.32 ± 7.48 mm2) presented a p<0.05. The GG (118.09 ± 10.4 mm2) compared to the CG (82.32 ± 7.48 mm2) presented a p>0.05.ConclusionGlutamine supplementation associated with induced periodontal disease demonstrated a smaller amount of bone loss compared to the periodontitis group.
publishDate 2018
dc.date.none.fl_str_mv 2018-11-12T17:27:15Z
2018-11-12T17:27:15Z
2018-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1807-2577.03718
Revista de Odontologia da UNESP. Universidade Estadual Paulista Júlio de Mesquita Filho, v. 47, n. 2, p. 119-123, 2018.
1807-2577
http://hdl.handle.net/11449/157859
10.1590/1807-2577.03718
S1807-25772018000200119
S1807-25772018000200119.pdf
url http://dx.doi.org/10.1590/1807-2577.03718
http://hdl.handle.net/11449/157859
identifier_str_mv Revista de Odontologia da UNESP. Universidade Estadual Paulista Júlio de Mesquita Filho, v. 47, n. 2, p. 119-123, 2018.
1807-2577
10.1590/1807-2577.03718
S1807-25772018000200119
S1807-25772018000200119.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista de Odontologia da UNESP
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 119-123
application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual Paulista Júlio de Mesquita Filho
publisher.none.fl_str_mv Universidade Estadual Paulista Júlio de Mesquita Filho
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128319361646592

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