Ejaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosterone

Detalhes bibliográficos
Autor(a) principal: Pontes, Davi A.
Data de Publicação: 2011
Outros Autores: Fernandes, Glaura S. A., Piffer, Renata C. [UNESP], Gerardin, Daniela C. C., Pereira, Oduvaldo C. M. [UNESP], Kempinas, Wilma G. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/S1734-1140(11)70407-8
http://hdl.handle.net/11449/226287
Resumo: Hyperglycemic and hypoinsulinemic states caused by diabetes mellitus are usually related to some type of sexual dysfunction, resulting in infertility in humans and experimental models, mostly due to their effects on ejaculatory function. This study aimed to evaluate the possible role of testosterone in the restoration of normal ejaculatory function in diabetic rats. Male Wistar rats were randomly allocated into 3 experimental groups: control, diabetic (streptozotocin), and diabetic with testosterone supplementation (streptozotocin plus testosterone). The following parameters were assessed at the end of the experiment: body weight, circulating testosterone levels, number of spermatozoa ejaculated in the uterus through natural mating, and weight and in vitro isometric contractions of the vas deferens. Diabetic rats showed reduced plasma testosterone levels and ejaculatory dysfunction as observed by a lack in the spermatozoa ejaculated into the uterus of receptive females. In these diabetic rats, no difference was observed in the sensitivity of the vas deferens to norepinephrine, with or without the presence of the cocktail (cocaine plus propranolol). In spite of this, an increased sensitivity to methoxamine through the α1-adrenoceptor was observed. Testosterone supplementation did not restore these parameters to control values. We conclude that, in this experimental model, the lack of testosterone was not directly related to the diabetes-induced ejaculatory dysfunction. Copyright © 2011 by Institute of Pharmacology Polish Academy of Sciences.
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spelling Ejaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosteroneDiabetesEjaculationInfertilityNorepinephrineTestosteroneHyperglycemic and hypoinsulinemic states caused by diabetes mellitus are usually related to some type of sexual dysfunction, resulting in infertility in humans and experimental models, mostly due to their effects on ejaculatory function. This study aimed to evaluate the possible role of testosterone in the restoration of normal ejaculatory function in diabetic rats. Male Wistar rats were randomly allocated into 3 experimental groups: control, diabetic (streptozotocin), and diabetic with testosterone supplementation (streptozotocin plus testosterone). The following parameters were assessed at the end of the experiment: body weight, circulating testosterone levels, number of spermatozoa ejaculated in the uterus through natural mating, and weight and in vitro isometric contractions of the vas deferens. Diabetic rats showed reduced plasma testosterone levels and ejaculatory dysfunction as observed by a lack in the spermatozoa ejaculated into the uterus of receptive females. In these diabetic rats, no difference was observed in the sensitivity of the vas deferens to norepinephrine, with or without the presence of the cocktail (cocaine plus propranolol). In spite of this, an increased sensitivity to methoxamine through the α1-adrenoceptor was observed. Testosterone supplementation did not restore these parameters to control values. We conclude that, in this experimental model, the lack of testosterone was not directly related to the diabetes-induced ejaculatory dysfunction. Copyright © 2011 by Institute of Pharmacology Polish Academy of Sciences.Graduate Program in Cellular and Structural Biology Institute of Biology State University of Campinas - UNICAMPGraduate Program in Medical Clinics Botucatu School of Medicine UNESP - Univ Estadual PaulistaBiological Sciences Center State University of Londrina UELDepartment of Pharmacology Institute of Biosciences of Botucatu UNESP - University Estadual PaulistaDepartment of Morphology Institute of Biosciences of Botucatu UNESP - University Estadual PaulistaGraduate Program in Medical Clinics Botucatu School of Medicine UNESP - Univ Estadual PaulistaDepartment of Pharmacology Institute of Biosciences of Botucatu UNESP - University Estadual PaulistaDepartment of Morphology Institute of Biosciences of Botucatu UNESP - University Estadual PaulistaUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)Universidade Estadual de Londrina (UEL)Pontes, Davi A.Fernandes, Glaura S. A.Piffer, Renata C. [UNESP]Gerardin, Daniela C. C.Pereira, Oduvaldo C. M. [UNESP]Kempinas, Wilma G. [UNESP]2022-04-28T22:36:59Z2022-04-28T22:36:59Z2011-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article130-138http://dx.doi.org/10.1016/S1734-1140(11)70407-8Pharmacological Reports, v. 63, n. 1, p. 130-138, 2011.1734-1140http://hdl.handle.net/11449/22628710.1016/S1734-1140(11)70407-82-s2.0-79953183702Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmacological Reportsinfo:eu-repo/semantics/openAccess2024-08-14T17:23:00Zoai:repositorio.unesp.br:11449/226287Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Ejaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosterone
title Ejaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosterone
spellingShingle Ejaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosterone
Pontes, Davi A.
Diabetes
Ejaculation
Infertility
Norepinephrine
Testosterone
title_short Ejaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosterone
title_full Ejaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosterone
title_fullStr Ejaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosterone
title_full_unstemmed Ejaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosterone
title_sort Ejaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosterone
author Pontes, Davi A.
author_facet Pontes, Davi A.
Fernandes, Glaura S. A.
Piffer, Renata C. [UNESP]
Gerardin, Daniela C. C.
Pereira, Oduvaldo C. M. [UNESP]
Kempinas, Wilma G. [UNESP]
author_role author
author2 Fernandes, Glaura S. A.
Piffer, Renata C. [UNESP]
Gerardin, Daniela C. C.
Pereira, Oduvaldo C. M. [UNESP]
Kempinas, Wilma G. [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (UNESP)
Universidade Estadual de Londrina (UEL)
dc.contributor.author.fl_str_mv Pontes, Davi A.
Fernandes, Glaura S. A.
Piffer, Renata C. [UNESP]
Gerardin, Daniela C. C.
Pereira, Oduvaldo C. M. [UNESP]
Kempinas, Wilma G. [UNESP]
dc.subject.por.fl_str_mv Diabetes
Ejaculation
Infertility
Norepinephrine
Testosterone
topic Diabetes
Ejaculation
Infertility
Norepinephrine
Testosterone
description Hyperglycemic and hypoinsulinemic states caused by diabetes mellitus are usually related to some type of sexual dysfunction, resulting in infertility in humans and experimental models, mostly due to their effects on ejaculatory function. This study aimed to evaluate the possible role of testosterone in the restoration of normal ejaculatory function in diabetic rats. Male Wistar rats were randomly allocated into 3 experimental groups: control, diabetic (streptozotocin), and diabetic with testosterone supplementation (streptozotocin plus testosterone). The following parameters were assessed at the end of the experiment: body weight, circulating testosterone levels, number of spermatozoa ejaculated in the uterus through natural mating, and weight and in vitro isometric contractions of the vas deferens. Diabetic rats showed reduced plasma testosterone levels and ejaculatory dysfunction as observed by a lack in the spermatozoa ejaculated into the uterus of receptive females. In these diabetic rats, no difference was observed in the sensitivity of the vas deferens to norepinephrine, with or without the presence of the cocktail (cocaine plus propranolol). In spite of this, an increased sensitivity to methoxamine through the α1-adrenoceptor was observed. Testosterone supplementation did not restore these parameters to control values. We conclude that, in this experimental model, the lack of testosterone was not directly related to the diabetes-induced ejaculatory dysfunction. Copyright © 2011 by Institute of Pharmacology Polish Academy of Sciences.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
2022-04-28T22:36:59Z
2022-04-28T22:36:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/S1734-1140(11)70407-8
Pharmacological Reports, v. 63, n. 1, p. 130-138, 2011.
1734-1140
http://hdl.handle.net/11449/226287
10.1016/S1734-1140(11)70407-8
2-s2.0-79953183702
url http://dx.doi.org/10.1016/S1734-1140(11)70407-8
http://hdl.handle.net/11449/226287
identifier_str_mv Pharmacological Reports, v. 63, n. 1, p. 130-138, 2011.
1734-1140
10.1016/S1734-1140(11)70407-8
2-s2.0-79953183702
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmacological Reports
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 130-138
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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