Tobacco influence in heavy metals levels in head and neck cancer cases
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s11356-018-2668-9 http://hdl.handle.net/11449/176668 |
Resumo: | Heavy metals intoxication is known to be risk factors for various diseases, including cancer. These metals may be presented in food and soil as well as in leaf and tobacco smoke. The aim of this study was to correlate the exposure to heavy metals stemming from tobacco and head and neck squamous cell carcinoma carcinogenesis. Analysis of lead, copper, manganese, arsenic, chromium, and cadmium by atomic absorption spectrophotometry was performed in whole blood samples from 91 patients: 68 smokers with oral cavity, pharynx, or laryngeal cancer; 8 non-smokers with oral or larynx cancer; and 15 non-cancer smokers with tobacco-related diseases (control group). No differences were found in metals quantifications, except a significant difference was observed (p = 0.0223) with higher mean in copper levels for non-smokers with cancer. The present study concluded, for the groups evaluated, it was not possible to prove the relationship between the studied metals in the development of the neoplasm. On the other hand, the results of copper demonstrated a correlation with smokers with cancer and lower levels of circulating copper. |
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Tobacco influence in heavy metals levels in head and neck cancer casesCarcinoma, squamous cellHead and neck neoplasmsMetals, heavyTobaccoHeavy metals intoxication is known to be risk factors for various diseases, including cancer. These metals may be presented in food and soil as well as in leaf and tobacco smoke. The aim of this study was to correlate the exposure to heavy metals stemming from tobacco and head and neck squamous cell carcinoma carcinogenesis. Analysis of lead, copper, manganese, arsenic, chromium, and cadmium by atomic absorption spectrophotometry was performed in whole blood samples from 91 patients: 68 smokers with oral cavity, pharynx, or laryngeal cancer; 8 non-smokers with oral or larynx cancer; and 15 non-cancer smokers with tobacco-related diseases (control group). No differences were found in metals quantifications, except a significant difference was observed (p = 0.0223) with higher mean in copper levels for non-smokers with cancer. The present study concluded, for the groups evaluated, it was not possible to prove the relationship between the studied metals in the development of the neoplasm. On the other hand, the results of copper demonstrated a correlation with smokers with cancer and lower levels of circulating copper.Department of Biosciences and Oral Diagnosis Sao Paulo State University (Unesp) Institute of Science and Technology, Av. Eng. Francisco José Longo 777Mogi das Cruzes University Braz CubasCenter of Toxicological Assistance (CEATOX) Sao Paulo State University (Unesp) Institute of Biosciences of BotucatuDepartment of Pharmacology Sao Paulo State University (Unesp) Institute of Biosciences of BotucatuDepartment of Head and Neck Surgery Medical Sciences College Irmandade daSanta Casa de Misericordia de Sao Paulo (ISCMSP)Department of Biosciences and Oral Diagnosis Sao Paulo State University (Unesp) Institute of Science and Technology, Av. Eng. Francisco José Longo 777Center of Toxicological Assistance (CEATOX) Sao Paulo State University (Unesp) Institute of Biosciences of BotucatuDepartment of Pharmacology Sao Paulo State University (Unesp) Institute of Biosciences of BotucatuUniversidade Estadual Paulista (Unesp)University Braz CubasIrmandade daSanta Casa de Misericordia de Sao Paulo (ISCMSP)Bandeira, Celso Muller [UNESP]de Almeida, Adriana Ávila [UNESP]Carta, Celina Faig LimaAlmeida, Alaor Aparecido [UNESP]de Figueiredo, Fellipe Augusto Tocchini [UNESP]Sandrim, Valeria Cristina [UNESP]Gonçalves, Antonio JoséAlmeida, Janete Dias [UNESP]2018-12-11T17:22:00Z2018-12-11T17:22:00Z2018-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article27650-27656application/pdfhttp://dx.doi.org/10.1007/s11356-018-2668-9Environmental Science and Pollution Research, v. 25, n. 27, p. 27650-27656, 2018.1614-74990944-1344http://hdl.handle.net/11449/17666810.1007/s11356-018-2668-92-s2.0-850509267862-s2.0-85050926786.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEnvironmental Science and Pollution Research0,858info:eu-repo/semantics/openAccess2024-04-10T18:10:59Zoai:repositorio.unesp.br:11449/176668Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:35:17.483425Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Tobacco influence in heavy metals levels in head and neck cancer cases |
title |
Tobacco influence in heavy metals levels in head and neck cancer cases |
spellingShingle |
Tobacco influence in heavy metals levels in head and neck cancer cases Bandeira, Celso Muller [UNESP] Carcinoma, squamous cell Head and neck neoplasms Metals, heavy Tobacco |
title_short |
Tobacco influence in heavy metals levels in head and neck cancer cases |
title_full |
Tobacco influence in heavy metals levels in head and neck cancer cases |
title_fullStr |
Tobacco influence in heavy metals levels in head and neck cancer cases |
title_full_unstemmed |
Tobacco influence in heavy metals levels in head and neck cancer cases |
title_sort |
Tobacco influence in heavy metals levels in head and neck cancer cases |
author |
Bandeira, Celso Muller [UNESP] |
author_facet |
Bandeira, Celso Muller [UNESP] de Almeida, Adriana Ávila [UNESP] Carta, Celina Faig Lima Almeida, Alaor Aparecido [UNESP] de Figueiredo, Fellipe Augusto Tocchini [UNESP] Sandrim, Valeria Cristina [UNESP] Gonçalves, Antonio José Almeida, Janete Dias [UNESP] |
author_role |
author |
author2 |
de Almeida, Adriana Ávila [UNESP] Carta, Celina Faig Lima Almeida, Alaor Aparecido [UNESP] de Figueiredo, Fellipe Augusto Tocchini [UNESP] Sandrim, Valeria Cristina [UNESP] Gonçalves, Antonio José Almeida, Janete Dias [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University Braz Cubas Irmandade daSanta Casa de Misericordia de Sao Paulo (ISCMSP) |
dc.contributor.author.fl_str_mv |
Bandeira, Celso Muller [UNESP] de Almeida, Adriana Ávila [UNESP] Carta, Celina Faig Lima Almeida, Alaor Aparecido [UNESP] de Figueiredo, Fellipe Augusto Tocchini [UNESP] Sandrim, Valeria Cristina [UNESP] Gonçalves, Antonio José Almeida, Janete Dias [UNESP] |
dc.subject.por.fl_str_mv |
Carcinoma, squamous cell Head and neck neoplasms Metals, heavy Tobacco |
topic |
Carcinoma, squamous cell Head and neck neoplasms Metals, heavy Tobacco |
description |
Heavy metals intoxication is known to be risk factors for various diseases, including cancer. These metals may be presented in food and soil as well as in leaf and tobacco smoke. The aim of this study was to correlate the exposure to heavy metals stemming from tobacco and head and neck squamous cell carcinoma carcinogenesis. Analysis of lead, copper, manganese, arsenic, chromium, and cadmium by atomic absorption spectrophotometry was performed in whole blood samples from 91 patients: 68 smokers with oral cavity, pharynx, or laryngeal cancer; 8 non-smokers with oral or larynx cancer; and 15 non-cancer smokers with tobacco-related diseases (control group). No differences were found in metals quantifications, except a significant difference was observed (p = 0.0223) with higher mean in copper levels for non-smokers with cancer. The present study concluded, for the groups evaluated, it was not possible to prove the relationship between the studied metals in the development of the neoplasm. On the other hand, the results of copper demonstrated a correlation with smokers with cancer and lower levels of circulating copper. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:22:00Z 2018-12-11T17:22:00Z 2018-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s11356-018-2668-9 Environmental Science and Pollution Research, v. 25, n. 27, p. 27650-27656, 2018. 1614-7499 0944-1344 http://hdl.handle.net/11449/176668 10.1007/s11356-018-2668-9 2-s2.0-85050926786 2-s2.0-85050926786.pdf |
url |
http://dx.doi.org/10.1007/s11356-018-2668-9 http://hdl.handle.net/11449/176668 |
identifier_str_mv |
Environmental Science and Pollution Research, v. 25, n. 27, p. 27650-27656, 2018. 1614-7499 0944-1344 10.1007/s11356-018-2668-9 2-s2.0-85050926786 2-s2.0-85050926786.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Environmental Science and Pollution Research 0,858 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
27650-27656 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128537280905216 |