Tobacco influence in heavy metals levels in head and neck cancer cases

Detalhes bibliográficos
Autor(a) principal: Bandeira, Celso Muller [UNESP]
Data de Publicação: 2018
Outros Autores: de Almeida, Adriana Ávila [UNESP], Carta, Celina Faig Lima, Almeida, Alaor Aparecido [UNESP], de Figueiredo, Fellipe Augusto Tocchini [UNESP], Sandrim, Valeria Cristina [UNESP], Gonçalves, Antonio José, Almeida, Janete Dias [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s11356-018-2668-9
http://hdl.handle.net/11449/176668
Resumo: Heavy metals intoxication is known to be risk factors for various diseases, including cancer. These metals may be presented in food and soil as well as in leaf and tobacco smoke. The aim of this study was to correlate the exposure to heavy metals stemming from tobacco and head and neck squamous cell carcinoma carcinogenesis. Analysis of lead, copper, manganese, arsenic, chromium, and cadmium by atomic absorption spectrophotometry was performed in whole blood samples from 91 patients: 68 smokers with oral cavity, pharynx, or laryngeal cancer; 8 non-smokers with oral or larynx cancer; and 15 non-cancer smokers with tobacco-related diseases (control group). No differences were found in metals quantifications, except a significant difference was observed (p = 0.0223) with higher mean in copper levels for non-smokers with cancer. The present study concluded, for the groups evaluated, it was not possible to prove the relationship between the studied metals in the development of the neoplasm. On the other hand, the results of copper demonstrated a correlation with smokers with cancer and lower levels of circulating copper.
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spelling Tobacco influence in heavy metals levels in head and neck cancer casesCarcinoma, squamous cellHead and neck neoplasmsMetals, heavyTobaccoHeavy metals intoxication is known to be risk factors for various diseases, including cancer. These metals may be presented in food and soil as well as in leaf and tobacco smoke. The aim of this study was to correlate the exposure to heavy metals stemming from tobacco and head and neck squamous cell carcinoma carcinogenesis. Analysis of lead, copper, manganese, arsenic, chromium, and cadmium by atomic absorption spectrophotometry was performed in whole blood samples from 91 patients: 68 smokers with oral cavity, pharynx, or laryngeal cancer; 8 non-smokers with oral or larynx cancer; and 15 non-cancer smokers with tobacco-related diseases (control group). No differences were found in metals quantifications, except a significant difference was observed (p = 0.0223) with higher mean in copper levels for non-smokers with cancer. The present study concluded, for the groups evaluated, it was not possible to prove the relationship between the studied metals in the development of the neoplasm. On the other hand, the results of copper demonstrated a correlation with smokers with cancer and lower levels of circulating copper.Department of Biosciences and Oral Diagnosis Sao Paulo State University (Unesp) Institute of Science and Technology, Av. Eng. Francisco José Longo 777Mogi das Cruzes University Braz CubasCenter of Toxicological Assistance (CEATOX) Sao Paulo State University (Unesp) Institute of Biosciences of BotucatuDepartment of Pharmacology Sao Paulo State University (Unesp) Institute of Biosciences of BotucatuDepartment of Head and Neck Surgery Medical Sciences College Irmandade daSanta Casa de Misericordia de Sao Paulo (ISCMSP)Department of Biosciences and Oral Diagnosis Sao Paulo State University (Unesp) Institute of Science and Technology, Av. Eng. Francisco José Longo 777Center of Toxicological Assistance (CEATOX) Sao Paulo State University (Unesp) Institute of Biosciences of BotucatuDepartment of Pharmacology Sao Paulo State University (Unesp) Institute of Biosciences of BotucatuUniversidade Estadual Paulista (Unesp)University Braz CubasIrmandade daSanta Casa de Misericordia de Sao Paulo (ISCMSP)Bandeira, Celso Muller [UNESP]de Almeida, Adriana Ávila [UNESP]Carta, Celina Faig LimaAlmeida, Alaor Aparecido [UNESP]de Figueiredo, Fellipe Augusto Tocchini [UNESP]Sandrim, Valeria Cristina [UNESP]Gonçalves, Antonio JoséAlmeida, Janete Dias [UNESP]2018-12-11T17:22:00Z2018-12-11T17:22:00Z2018-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article27650-27656application/pdfhttp://dx.doi.org/10.1007/s11356-018-2668-9Environmental Science and Pollution Research, v. 25, n. 27, p. 27650-27656, 2018.1614-74990944-1344http://hdl.handle.net/11449/17666810.1007/s11356-018-2668-92-s2.0-850509267862-s2.0-85050926786.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEnvironmental Science and Pollution Research0,858info:eu-repo/semantics/openAccess2024-04-10T18:10:59Zoai:repositorio.unesp.br:11449/176668Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:35:17.483425Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Tobacco influence in heavy metals levels in head and neck cancer cases
title Tobacco influence in heavy metals levels in head and neck cancer cases
spellingShingle Tobacco influence in heavy metals levels in head and neck cancer cases
Bandeira, Celso Muller [UNESP]
Carcinoma, squamous cell
Head and neck neoplasms
Metals, heavy
Tobacco
title_short Tobacco influence in heavy metals levels in head and neck cancer cases
title_full Tobacco influence in heavy metals levels in head and neck cancer cases
title_fullStr Tobacco influence in heavy metals levels in head and neck cancer cases
title_full_unstemmed Tobacco influence in heavy metals levels in head and neck cancer cases
title_sort Tobacco influence in heavy metals levels in head and neck cancer cases
author Bandeira, Celso Muller [UNESP]
author_facet Bandeira, Celso Muller [UNESP]
de Almeida, Adriana Ávila [UNESP]
Carta, Celina Faig Lima
Almeida, Alaor Aparecido [UNESP]
de Figueiredo, Fellipe Augusto Tocchini [UNESP]
Sandrim, Valeria Cristina [UNESP]
Gonçalves, Antonio José
Almeida, Janete Dias [UNESP]
author_role author
author2 de Almeida, Adriana Ávila [UNESP]
Carta, Celina Faig Lima
Almeida, Alaor Aparecido [UNESP]
de Figueiredo, Fellipe Augusto Tocchini [UNESP]
Sandrim, Valeria Cristina [UNESP]
Gonçalves, Antonio José
Almeida, Janete Dias [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
University Braz Cubas
Irmandade daSanta Casa de Misericordia de Sao Paulo (ISCMSP)
dc.contributor.author.fl_str_mv Bandeira, Celso Muller [UNESP]
de Almeida, Adriana Ávila [UNESP]
Carta, Celina Faig Lima
Almeida, Alaor Aparecido [UNESP]
de Figueiredo, Fellipe Augusto Tocchini [UNESP]
Sandrim, Valeria Cristina [UNESP]
Gonçalves, Antonio José
Almeida, Janete Dias [UNESP]
dc.subject.por.fl_str_mv Carcinoma, squamous cell
Head and neck neoplasms
Metals, heavy
Tobacco
topic Carcinoma, squamous cell
Head and neck neoplasms
Metals, heavy
Tobacco
description Heavy metals intoxication is known to be risk factors for various diseases, including cancer. These metals may be presented in food and soil as well as in leaf and tobacco smoke. The aim of this study was to correlate the exposure to heavy metals stemming from tobacco and head and neck squamous cell carcinoma carcinogenesis. Analysis of lead, copper, manganese, arsenic, chromium, and cadmium by atomic absorption spectrophotometry was performed in whole blood samples from 91 patients: 68 smokers with oral cavity, pharynx, or laryngeal cancer; 8 non-smokers with oral or larynx cancer; and 15 non-cancer smokers with tobacco-related diseases (control group). No differences were found in metals quantifications, except a significant difference was observed (p = 0.0223) with higher mean in copper levels for non-smokers with cancer. The present study concluded, for the groups evaluated, it was not possible to prove the relationship between the studied metals in the development of the neoplasm. On the other hand, the results of copper demonstrated a correlation with smokers with cancer and lower levels of circulating copper.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:22:00Z
2018-12-11T17:22:00Z
2018-09-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s11356-018-2668-9
Environmental Science and Pollution Research, v. 25, n. 27, p. 27650-27656, 2018.
1614-7499
0944-1344
http://hdl.handle.net/11449/176668
10.1007/s11356-018-2668-9
2-s2.0-85050926786
2-s2.0-85050926786.pdf
url http://dx.doi.org/10.1007/s11356-018-2668-9
http://hdl.handle.net/11449/176668
identifier_str_mv Environmental Science and Pollution Research, v. 25, n. 27, p. 27650-27656, 2018.
1614-7499
0944-1344
10.1007/s11356-018-2668-9
2-s2.0-85050926786
2-s2.0-85050926786.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Environmental Science and Pollution Research
0,858
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 27650-27656
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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