Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2527/jas.2015-9424 http://hdl.handle.net/11449/158623 |
Resumo: | This study evaluated the effects of oral meloxicam administration on metabolic, inflammatory, and acute-phase responses of beef cattle receiving a lipopolysaccharide (LPS) challenge (Exp. 1; d - 1 to 6) or vaccinated against respiratory pathogens (Exp. 2; d 7 to 21). Twenty-one Angus steers (n = 11) and heifers (n = 10) were housed in individual pens on d - 15 and were offered free-choice water, mineral-vitamin mix, and hay until d 21. In Exp. 1, cattle were ranked on d - 1 by sex and BW and assigned to 1) oral meloxicam administration (1 mg/kg BW daily) from day - 1 to 6 (MEL8), 2) oral meloxicam administration (1 mg/kg BW) on d 0 and oral lactose monohydrate administration (1 mg/kg BW) on d - 1 and from d 1 to 6 (MEL1), or 3) oral lactose monohydrate administration (1 mg/kg BW daily) from d - 1 to 6 (CON). On d 0, cattle received an intravenous LPS bolus (0.5 mu g/kg BW) concurrently with treatment administration. Rectal temperature (RTEMP) was assessed, and blood samples were collected at -2, 0, 2, 4, 6, 8, 12, 16, 24, 36, 48, 60, 72, 96, 120, and 144 h relative to LPS administration. No treatment effects were detected (P >= 0.36) for RTEMP, concentrations of serum tumor necrosis factor a (TNF alpha), plasma haptoglobin, cortisol, insulin, and leptin, as well as blood mRNA expression of TNF alpha and cyclooxygenase-2, although all variables increased (P < 0.01) across treatments after LPS administration. In Exp. 2, cattle received the same treatments that they were assigned to in Exp. 1 from d 7 to d 13 and were vaccinated against respiratory pathogens concurrently with treatment administration on d 8. Blood samples were collected, and RTEMP was assessed as in Exp. 1 in addition to 168, 240, and 336 h relative to vaccination. No treatment effects were detected (P >= 0.26) for RTEMP, the same plasma and serum variables evaluated in Exp. 1, and serum concentrations of antibodies against Mannheimia haemolytica or serum titers against bovine respiratory syncytial virus, bovine herpesvirus-1, bovine viral diarrhea virus-1, and parainfluenza-3 virus. All variables increased (P < 0.01) across treatments after vaccination, except for serum TNF alpha and titers against bovine viral diarrhea virus-1 (P >= 0.40). Collectively, this study found no evidence that oral meloxicam administration, at the doses and intervals utilized herein, mitigated the metabolic, inflammatory, and acute-phase reactions elicited by LPS administration or vaccination against respiratory pathogens. |
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Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogensbeef cattleinflammationlipopolysaccharidemeloxicamvaccinationThis study evaluated the effects of oral meloxicam administration on metabolic, inflammatory, and acute-phase responses of beef cattle receiving a lipopolysaccharide (LPS) challenge (Exp. 1; d - 1 to 6) or vaccinated against respiratory pathogens (Exp. 2; d 7 to 21). Twenty-one Angus steers (n = 11) and heifers (n = 10) were housed in individual pens on d - 15 and were offered free-choice water, mineral-vitamin mix, and hay until d 21. In Exp. 1, cattle were ranked on d - 1 by sex and BW and assigned to 1) oral meloxicam administration (1 mg/kg BW daily) from day - 1 to 6 (MEL8), 2) oral meloxicam administration (1 mg/kg BW) on d 0 and oral lactose monohydrate administration (1 mg/kg BW) on d - 1 and from d 1 to 6 (MEL1), or 3) oral lactose monohydrate administration (1 mg/kg BW daily) from d - 1 to 6 (CON). On d 0, cattle received an intravenous LPS bolus (0.5 mu g/kg BW) concurrently with treatment administration. Rectal temperature (RTEMP) was assessed, and blood samples were collected at -2, 0, 2, 4, 6, 8, 12, 16, 24, 36, 48, 60, 72, 96, 120, and 144 h relative to LPS administration. No treatment effects were detected (P >= 0.36) for RTEMP, concentrations of serum tumor necrosis factor a (TNF alpha), plasma haptoglobin, cortisol, insulin, and leptin, as well as blood mRNA expression of TNF alpha and cyclooxygenase-2, although all variables increased (P < 0.01) across treatments after LPS administration. In Exp. 2, cattle received the same treatments that they were assigned to in Exp. 1 from d 7 to d 13 and were vaccinated against respiratory pathogens concurrently with treatment administration on d 8. Blood samples were collected, and RTEMP was assessed as in Exp. 1 in addition to 168, 240, and 336 h relative to vaccination. No treatment effects were detected (P >= 0.26) for RTEMP, the same plasma and serum variables evaluated in Exp. 1, and serum concentrations of antibodies against Mannheimia haemolytica or serum titers against bovine respiratory syncytial virus, bovine herpesvirus-1, bovine viral diarrhea virus-1, and parainfluenza-3 virus. All variables increased (P < 0.01) across treatments after vaccination, except for serum TNF alpha and titers against bovine viral diarrhea virus-1 (P >= 0.40). Collectively, this study found no evidence that oral meloxicam administration, at the doses and intervals utilized herein, mitigated the metabolic, inflammatory, and acute-phase reactions elicited by LPS administration or vaccination against respiratory pathogens.USDA-NIFA OregonCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Oregon State Univ, Eastern Oregon Agr Res Ctr, Burns, OR 97720 USAUniv Estadual Paulista, Programa Posgrad Zootecnia, Fac Med Vet & Zootecnia, BR-18618970 Botucatu, SP, BrazilOregon State Univ, Malheur Cty Extens Off, Toronto, ON 97914, CanadaUniv Missouri, Dept Anim Sci, Columbia, MO 65211 USAUniv Estadual Paulista, Programa Posgrad Zootecnia, Fac Med Vet & Zootecnia, BR-18618970 Botucatu, SP, BrazilUSDA-NIFA Oregon: ORE00121Amer Soc Animal ScienceOregon State UnivUniversidade Estadual Paulista (Unesp)Univ MissouriRodrigues, M. C. [UNESP]Cooke, R. F.Marques, R. S.Arispe, S. A.Keisler, D. H.Bohnert, D. W.2018-11-26T15:28:22Z2018-11-26T15:28:22Z2015-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5018-5027application/pdfhttp://dx.doi.org/10.2527/jas.2015-9424Journal Of Animal Science. Champaign: Amer Soc Animal Science, v. 93, n. 10, p. 5018-5027, 2015.0021-8812http://hdl.handle.net/11449/15862310.2527/jas.2015-9424WOS:000366326100044WOS000366326100044.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Animal Science0,848info:eu-repo/semantics/openAccess2023-11-07T06:11:19Zoai:repositorio.unesp.br:11449/158623Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-07T06:11:19Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens |
title |
Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens |
spellingShingle |
Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens Rodrigues, M. C. [UNESP] beef cattle inflammation lipopolysaccharide meloxicam vaccination |
title_short |
Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens |
title_full |
Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens |
title_fullStr |
Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens |
title_full_unstemmed |
Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens |
title_sort |
Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens |
author |
Rodrigues, M. C. [UNESP] |
author_facet |
Rodrigues, M. C. [UNESP] Cooke, R. F. Marques, R. S. Arispe, S. A. Keisler, D. H. Bohnert, D. W. |
author_role |
author |
author2 |
Cooke, R. F. Marques, R. S. Arispe, S. A. Keisler, D. H. Bohnert, D. W. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Oregon State Univ Universidade Estadual Paulista (Unesp) Univ Missouri |
dc.contributor.author.fl_str_mv |
Rodrigues, M. C. [UNESP] Cooke, R. F. Marques, R. S. Arispe, S. A. Keisler, D. H. Bohnert, D. W. |
dc.subject.por.fl_str_mv |
beef cattle inflammation lipopolysaccharide meloxicam vaccination |
topic |
beef cattle inflammation lipopolysaccharide meloxicam vaccination |
description |
This study evaluated the effects of oral meloxicam administration on metabolic, inflammatory, and acute-phase responses of beef cattle receiving a lipopolysaccharide (LPS) challenge (Exp. 1; d - 1 to 6) or vaccinated against respiratory pathogens (Exp. 2; d 7 to 21). Twenty-one Angus steers (n = 11) and heifers (n = 10) were housed in individual pens on d - 15 and were offered free-choice water, mineral-vitamin mix, and hay until d 21. In Exp. 1, cattle were ranked on d - 1 by sex and BW and assigned to 1) oral meloxicam administration (1 mg/kg BW daily) from day - 1 to 6 (MEL8), 2) oral meloxicam administration (1 mg/kg BW) on d 0 and oral lactose monohydrate administration (1 mg/kg BW) on d - 1 and from d 1 to 6 (MEL1), or 3) oral lactose monohydrate administration (1 mg/kg BW daily) from d - 1 to 6 (CON). On d 0, cattle received an intravenous LPS bolus (0.5 mu g/kg BW) concurrently with treatment administration. Rectal temperature (RTEMP) was assessed, and blood samples were collected at -2, 0, 2, 4, 6, 8, 12, 16, 24, 36, 48, 60, 72, 96, 120, and 144 h relative to LPS administration. No treatment effects were detected (P >= 0.36) for RTEMP, concentrations of serum tumor necrosis factor a (TNF alpha), plasma haptoglobin, cortisol, insulin, and leptin, as well as blood mRNA expression of TNF alpha and cyclooxygenase-2, although all variables increased (P < 0.01) across treatments after LPS administration. In Exp. 2, cattle received the same treatments that they were assigned to in Exp. 1 from d 7 to d 13 and were vaccinated against respiratory pathogens concurrently with treatment administration on d 8. Blood samples were collected, and RTEMP was assessed as in Exp. 1 in addition to 168, 240, and 336 h relative to vaccination. No treatment effects were detected (P >= 0.26) for RTEMP, the same plasma and serum variables evaluated in Exp. 1, and serum concentrations of antibodies against Mannheimia haemolytica or serum titers against bovine respiratory syncytial virus, bovine herpesvirus-1, bovine viral diarrhea virus-1, and parainfluenza-3 virus. All variables increased (P < 0.01) across treatments after vaccination, except for serum TNF alpha and titers against bovine viral diarrhea virus-1 (P >= 0.40). Collectively, this study found no evidence that oral meloxicam administration, at the doses and intervals utilized herein, mitigated the metabolic, inflammatory, and acute-phase reactions elicited by LPS administration or vaccination against respiratory pathogens. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-01 2018-11-26T15:28:22Z 2018-11-26T15:28:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2527/jas.2015-9424 Journal Of Animal Science. Champaign: Amer Soc Animal Science, v. 93, n. 10, p. 5018-5027, 2015. 0021-8812 http://hdl.handle.net/11449/158623 10.2527/jas.2015-9424 WOS:000366326100044 WOS000366326100044.pdf |
url |
http://dx.doi.org/10.2527/jas.2015-9424 http://hdl.handle.net/11449/158623 |
identifier_str_mv |
Journal Of Animal Science. Champaign: Amer Soc Animal Science, v. 93, n. 10, p. 5018-5027, 2015. 0021-8812 10.2527/jas.2015-9424 WOS:000366326100044 WOS000366326100044.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Animal Science 0,848 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
5018-5027 application/pdf |
dc.publisher.none.fl_str_mv |
Amer Soc Animal Science |
publisher.none.fl_str_mv |
Amer Soc Animal Science |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964849068834816 |