Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1415-47572005000300011 http://hdl.handle.net/11449/30478 |
Resumo: | In several DNA repair genes, polymorphisms may result in reduced repair capacity, which has been implicated as a risk factor for various types of cancer. The frequency of the polymorphic alleles varies among populations, suggesting an ethnic distribution of genotypes. We genotyped 300 healthy Southeastern Brazilian individuals (262 of European ancestry and 38 of African ancestry) for polymorphisms of codons 194 and 399 of the XRCC1 base excision repair pathway gene and of codon 241 of the XRCC3 homologous recombination repair pathway gene. The allele frequencies were 0.07 for the Arg194Trp and 0.33 for the Arg399Gln codons of the XRCC1 gene and 0.35 for the Thr241Met codon of the XRCC3 gene. The genotypic frequencies were within Hardy-Weinberg equilibrium. These frequencies showed ethnic variability when compared with those obtained for different populations from several countries. |
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Repositório Institucional da UNESP |
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Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian populationDNA repairXRCC1XRCC3Polymorphismethnic variabilityIn several DNA repair genes, polymorphisms may result in reduced repair capacity, which has been implicated as a risk factor for various types of cancer. The frequency of the polymorphic alleles varies among populations, suggesting an ethnic distribution of genotypes. We genotyped 300 healthy Southeastern Brazilian individuals (262 of European ancestry and 38 of African ancestry) for polymorphisms of codons 194 and 399 of the XRCC1 base excision repair pathway gene and of codon 241 of the XRCC3 homologous recombination repair pathway gene. The allele frequencies were 0.07 for the Arg194Trp and 0.33 for the Arg399Gln codons of the XRCC1 gene and 0.35 for the Thr241Met codon of the XRCC3 gene. The genotypic frequencies were within Hardy-Weinberg equilibrium. These frequencies showed ethnic variability when compared with those obtained for different populations from several countries.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual Paulista Instituto de Biociências Letras e Ciências ExatasFaculdade de Medicina de São José do Rio Preto (FAMERP) Centro de Investigação de MicroorganismosUniversidade Estadual Paulista Instituto de Biociências Letras e Ciências ExatasSociedade Brasileira de GenéticaUniversidade Estadual Paulista (Unesp)Faculdade de Medicina de São José do Rio Preto (FAMERP)Duarte, Márcia Cristina [UNESP]Colombo, Jucimara [UNESP]Rossit, Andréa Regina BaptistaSilva, Ana Elizabete [UNESP]2014-05-20T15:17:28Z2014-05-20T15:17:28Z2005-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article397-401application/pdfhttp://dx.doi.org/10.1590/S1415-47572005000300011Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 28, n. 3, p. 397-401, 2005.1415-4757http://hdl.handle.net/11449/3047810.1590/S1415-47572005000300011S1415-47572005000300011S1415-47572005000300011.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics and Molecular Biology1.4930,638info:eu-repo/semantics/openAccess2023-10-11T06:09:22Zoai:repositorio.unesp.br:11449/30478Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:38:20.629086Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population |
title |
Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population |
spellingShingle |
Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population Duarte, Márcia Cristina [UNESP] DNA repair XRCC1 XRCC3 Polymorphism ethnic variability |
title_short |
Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population |
title_full |
Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population |
title_fullStr |
Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population |
title_full_unstemmed |
Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population |
title_sort |
Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population |
author |
Duarte, Márcia Cristina [UNESP] |
author_facet |
Duarte, Márcia Cristina [UNESP] Colombo, Jucimara [UNESP] Rossit, Andréa Regina Baptista Silva, Ana Elizabete [UNESP] |
author_role |
author |
author2 |
Colombo, Jucimara [UNESP] Rossit, Andréa Regina Baptista Silva, Ana Elizabete [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Faculdade de Medicina de São José do Rio Preto (FAMERP) |
dc.contributor.author.fl_str_mv |
Duarte, Márcia Cristina [UNESP] Colombo, Jucimara [UNESP] Rossit, Andréa Regina Baptista Silva, Ana Elizabete [UNESP] |
dc.subject.por.fl_str_mv |
DNA repair XRCC1 XRCC3 Polymorphism ethnic variability |
topic |
DNA repair XRCC1 XRCC3 Polymorphism ethnic variability |
description |
In several DNA repair genes, polymorphisms may result in reduced repair capacity, which has been implicated as a risk factor for various types of cancer. The frequency of the polymorphic alleles varies among populations, suggesting an ethnic distribution of genotypes. We genotyped 300 healthy Southeastern Brazilian individuals (262 of European ancestry and 38 of African ancestry) for polymorphisms of codons 194 and 399 of the XRCC1 base excision repair pathway gene and of codon 241 of the XRCC3 homologous recombination repair pathway gene. The allele frequencies were 0.07 for the Arg194Trp and 0.33 for the Arg399Gln codons of the XRCC1 gene and 0.35 for the Thr241Met codon of the XRCC3 gene. The genotypic frequencies were within Hardy-Weinberg equilibrium. These frequencies showed ethnic variability when compared with those obtained for different populations from several countries. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-09-01 2014-05-20T15:17:28Z 2014-05-20T15:17:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1415-47572005000300011 Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 28, n. 3, p. 397-401, 2005. 1415-4757 http://hdl.handle.net/11449/30478 10.1590/S1415-47572005000300011 S1415-47572005000300011 S1415-47572005000300011.pdf |
url |
http://dx.doi.org/10.1590/S1415-47572005000300011 http://hdl.handle.net/11449/30478 |
identifier_str_mv |
Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 28, n. 3, p. 397-401, 2005. 1415-4757 10.1590/S1415-47572005000300011 S1415-47572005000300011 S1415-47572005000300011.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Genetics and Molecular Biology 1.493 0,638 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
397-401 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128392480948224 |