Niveles séricos de magnesio en perros sanos sometidos a la administración de cisplatino con terapia de líquidos
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng spa |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/231269 |
Resumo: | Cisplatin is an antineoplastic drug that is used to treat carcinomas and osteosarcomas in dogs. However, it can cause kidney damage which in turn leads to the loss of electrolytes. Concentration of magnesium was evaluated in the blood serum of eight dogs that had undergone therapy with cisplatin. The dogs were divided into two groups. Group 1 was supply with cisplatin (70 mg/m2, iv) and to prevent nephrotoxcity, saline solution at 0.9% was administered (25 ml/kg/hour, iv in three hours). The animals in Group 2 were not supplied with cisplatin. There was no significant difference (P < 0.05) between the two groups and the results obtained indicated that the protocol used for Group 1 did not cause changes in the serum concentrations of magnesium. Therefore, it can be concluded that the administration of cisplatin does not cause variations if it is combined with the fluid therapy. |
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Niveles séricos de magnesio en perros sanos sometidos a la administración de cisplatino con terapia de líquidosSerum magnesium levels in healthy dogs submitted to the administration of cisplatin with fluid therapyChemotherapyCisplatinElectrolytesFluid therapyMagnesiumCisplatin is an antineoplastic drug that is used to treat carcinomas and osteosarcomas in dogs. However, it can cause kidney damage which in turn leads to the loss of electrolytes. Concentration of magnesium was evaluated in the blood serum of eight dogs that had undergone therapy with cisplatin. The dogs were divided into two groups. Group 1 was supply with cisplatin (70 mg/m2, iv) and to prevent nephrotoxcity, saline solution at 0.9% was administered (25 ml/kg/hour, iv in three hours). The animals in Group 2 were not supplied with cisplatin. There was no significant difference (P < 0.05) between the two groups and the results obtained indicated that the protocol used for Group 1 did not cause changes in the serum concentrations of magnesium. Therefore, it can be concluded that the administration of cisplatin does not cause variations if it is combined with the fluid therapy.Departamento de Sanidad Animal Facultad de Ciencias Pecuarias Universidad de Nariño, Ciudad Universitaria Torobajo, Pasto, NariñoServicio de Oncología Veterinaria Facultad de Medicina Veterinaria y Zootecnia Universidad Estatal Paulista, CEP 14884-900, Jaboticabal, Estado de São PauloUniversidad de Nariño, Ciudad Universitaria TorobajoUniversidad Estatal PaulistaOliva, Carlos Alfredo CalpaDaleck, Carlos Robertode Castro, João Humberto Teotôniode Nardi, Andrigo Barboza2022-04-29T08:44:26Z2022-04-29T08:44:26Z2011-08-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article46-57Veterinaria Mexico, v. 42, n. 1, p. 46-57, 2011.0301-5092http://hdl.handle.net/11449/2312692-s2.0-80051779222Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengspaVeterinaria Mexicoinfo:eu-repo/semantics/openAccess2024-06-07T18:44:29Zoai:repositorio.unesp.br:11449/231269Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-06-07T18:44:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Niveles séricos de magnesio en perros sanos sometidos a la administración de cisplatino con terapia de líquidos Serum magnesium levels in healthy dogs submitted to the administration of cisplatin with fluid therapy |
title |
Niveles séricos de magnesio en perros sanos sometidos a la administración de cisplatino con terapia de líquidos |
spellingShingle |
Niveles séricos de magnesio en perros sanos sometidos a la administración de cisplatino con terapia de líquidos Oliva, Carlos Alfredo Calpa Chemotherapy Cisplatin Electrolytes Fluid therapy Magnesium |
title_short |
Niveles séricos de magnesio en perros sanos sometidos a la administración de cisplatino con terapia de líquidos |
title_full |
Niveles séricos de magnesio en perros sanos sometidos a la administración de cisplatino con terapia de líquidos |
title_fullStr |
Niveles séricos de magnesio en perros sanos sometidos a la administración de cisplatino con terapia de líquidos |
title_full_unstemmed |
Niveles séricos de magnesio en perros sanos sometidos a la administración de cisplatino con terapia de líquidos |
title_sort |
Niveles séricos de magnesio en perros sanos sometidos a la administración de cisplatino con terapia de líquidos |
author |
Oliva, Carlos Alfredo Calpa |
author_facet |
Oliva, Carlos Alfredo Calpa Daleck, Carlos Roberto de Castro, João Humberto Teotônio de Nardi, Andrigo Barboza |
author_role |
author |
author2 |
Daleck, Carlos Roberto de Castro, João Humberto Teotônio de Nardi, Andrigo Barboza |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidad de Nariño, Ciudad Universitaria Torobajo Universidad Estatal Paulista |
dc.contributor.author.fl_str_mv |
Oliva, Carlos Alfredo Calpa Daleck, Carlos Roberto de Castro, João Humberto Teotônio de Nardi, Andrigo Barboza |
dc.subject.por.fl_str_mv |
Chemotherapy Cisplatin Electrolytes Fluid therapy Magnesium |
topic |
Chemotherapy Cisplatin Electrolytes Fluid therapy Magnesium |
description |
Cisplatin is an antineoplastic drug that is used to treat carcinomas and osteosarcomas in dogs. However, it can cause kidney damage which in turn leads to the loss of electrolytes. Concentration of magnesium was evaluated in the blood serum of eight dogs that had undergone therapy with cisplatin. The dogs were divided into two groups. Group 1 was supply with cisplatin (70 mg/m2, iv) and to prevent nephrotoxcity, saline solution at 0.9% was administered (25 ml/kg/hour, iv in three hours). The animals in Group 2 were not supplied with cisplatin. There was no significant difference (P < 0.05) between the two groups and the results obtained indicated that the protocol used for Group 1 did not cause changes in the serum concentrations of magnesium. Therefore, it can be concluded that the administration of cisplatin does not cause variations if it is combined with the fluid therapy. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-08-22 2022-04-29T08:44:26Z 2022-04-29T08:44:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Veterinaria Mexico, v. 42, n. 1, p. 46-57, 2011. 0301-5092 http://hdl.handle.net/11449/231269 2-s2.0-80051779222 |
identifier_str_mv |
Veterinaria Mexico, v. 42, n. 1, p. 46-57, 2011. 0301-5092 2-s2.0-80051779222 |
url |
http://hdl.handle.net/11449/231269 |
dc.language.iso.fl_str_mv |
eng spa |
language |
eng spa |
dc.relation.none.fl_str_mv |
Veterinaria Mexico |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
46-57 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803045532403236864 |