Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood

Detalhes bibliográficos
Autor(a) principal: Cavalleri Sousa, Thainá
Data de Publicação: 2022
Outros Autores: de Oliveira, Camila Bonillo, Silva Ricardo, Maria Luiza, Musa de Aquino, Ariana [UNESP], Scarano, Wellerson Rodrigo [UNESP], Cruz Veras, Allice Santos [UNESP], Almeida Tavares, Maria Eduarda [UNESP], Teixeira, Giovana Rampazzo [UNESP], Castillho, Anthony César deSousa, Pacagnelli, Francis Lopes, Zalotti Brandt, Joyce, de Oliveira Mendes, Leonardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/09603123.2022.2140127
http://hdl.handle.net/11449/249342
Resumo: Bisphenol A (BPA) is an environmentally dispersed chemical associated with tumor development. Phytochemicals such as indole-3-carbinol (I3C) and genistein (GEN) have chemoprotective effects on tumor cells. Thus, this study aimed to evaluate the prostatic morphological aspects of rats exposed to BPA, GEN, and I3C during the perinatal period and submitted to hormonal stimulus in adulthood. Blood was collected to obtain hormone concentrations. Slides stained with hematoxylin & eosin, and picrosirius were subjected to fractal, stereological, morphometric, and collagen quantification analysis. I3C decreased the plasma dihydrotestosterone levels, and both phytochemicals increased the plasma estrogen levels. Unlike phytochemicals, BPA did not alter any of the parameters evaluated. GEN reduced the epithelial height, while I3C increased the fractal dimension and stromal collagen. Although BPA did not alter the prostate morphology, the phytochemicals provided beneficial effects for the prostate histological organization in adult animals subjected to hormonal stimulus.
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spelling Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthoodEndocrine disruptorsgenisteinindole-3-carbinolBisphenol A (BPA) is an environmentally dispersed chemical associated with tumor development. Phytochemicals such as indole-3-carbinol (I3C) and genistein (GEN) have chemoprotective effects on tumor cells. Thus, this study aimed to evaluate the prostatic morphological aspects of rats exposed to BPA, GEN, and I3C during the perinatal period and submitted to hormonal stimulus in adulthood. Blood was collected to obtain hormone concentrations. Slides stained with hematoxylin & eosin, and picrosirius were subjected to fractal, stereological, morphometric, and collagen quantification analysis. I3C decreased the plasma dihydrotestosterone levels, and both phytochemicals increased the plasma estrogen levels. Unlike phytochemicals, BPA did not alter any of the parameters evaluated. GEN reduced the epithelial height, while I3C increased the fractal dimension and stromal collagen. Although BPA did not alter the prostate morphology, the phytochemicals provided beneficial effects for the prostate histological organization in adult animals subjected to hormonal stimulus.Graduate Program in Animal Science Western São Paulo University (UNOESTE)Department of Functional and Structural Biology IBB/UNESPExperimental Laboratory of Exercise Biology (LEBioEx) São Paulo State University (UNESP)Department of Nutrition Unimed HospitalMaster Program in Health Science Western São Paulo University (UNOESTE)Department of Functional and Structural Biology IBB/UNESPExperimental Laboratory of Exercise Biology (LEBioEx) São Paulo State University (UNESP)Universidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Unimed HospitalCavalleri Sousa, Thaináde Oliveira, Camila BonilloSilva Ricardo, Maria LuizaMusa de Aquino, Ariana [UNESP]Scarano, Wellerson Rodrigo [UNESP]Cruz Veras, Allice Santos [UNESP]Almeida Tavares, Maria Eduarda [UNESP]Teixeira, Giovana Rampazzo [UNESP]Castillho, Anthony César deSousaPacagnelli, Francis LopesZalotti Brandt, Joycede Oliveira Mendes, Leonardo2023-07-29T15:13:27Z2023-07-29T15:13:27Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/09603123.2022.2140127International Journal of Environmental Health Research.1369-16190960-3123http://hdl.handle.net/11449/24934210.1080/09603123.2022.21401272-s2.0-85141414238Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Environmental Health Researchinfo:eu-repo/semantics/openAccess2023-07-29T15:13:27Zoai:repositorio.unesp.br:11449/249342Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:05:11.104631Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood
title Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood
spellingShingle Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood
Cavalleri Sousa, Thainá
Endocrine disruptors
genistein
indole-3-carbinol
title_short Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood
title_full Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood
title_fullStr Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood
title_full_unstemmed Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood
title_sort Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood
author Cavalleri Sousa, Thainá
author_facet Cavalleri Sousa, Thainá
de Oliveira, Camila Bonillo
Silva Ricardo, Maria Luiza
Musa de Aquino, Ariana [UNESP]
Scarano, Wellerson Rodrigo [UNESP]
Cruz Veras, Allice Santos [UNESP]
Almeida Tavares, Maria Eduarda [UNESP]
Teixeira, Giovana Rampazzo [UNESP]
Castillho, Anthony César deSousa
Pacagnelli, Francis Lopes
Zalotti Brandt, Joyce
de Oliveira Mendes, Leonardo
author_role author
author2 de Oliveira, Camila Bonillo
Silva Ricardo, Maria Luiza
Musa de Aquino, Ariana [UNESP]
Scarano, Wellerson Rodrigo [UNESP]
Cruz Veras, Allice Santos [UNESP]
Almeida Tavares, Maria Eduarda [UNESP]
Teixeira, Giovana Rampazzo [UNESP]
Castillho, Anthony César deSousa
Pacagnelli, Francis Lopes
Zalotti Brandt, Joyce
de Oliveira Mendes, Leonardo
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (UNESP)
Unimed Hospital
dc.contributor.author.fl_str_mv Cavalleri Sousa, Thainá
de Oliveira, Camila Bonillo
Silva Ricardo, Maria Luiza
Musa de Aquino, Ariana [UNESP]
Scarano, Wellerson Rodrigo [UNESP]
Cruz Veras, Allice Santos [UNESP]
Almeida Tavares, Maria Eduarda [UNESP]
Teixeira, Giovana Rampazzo [UNESP]
Castillho, Anthony César deSousa
Pacagnelli, Francis Lopes
Zalotti Brandt, Joyce
de Oliveira Mendes, Leonardo
dc.subject.por.fl_str_mv Endocrine disruptors
genistein
indole-3-carbinol
topic Endocrine disruptors
genistein
indole-3-carbinol
description Bisphenol A (BPA) is an environmentally dispersed chemical associated with tumor development. Phytochemicals such as indole-3-carbinol (I3C) and genistein (GEN) have chemoprotective effects on tumor cells. Thus, this study aimed to evaluate the prostatic morphological aspects of rats exposed to BPA, GEN, and I3C during the perinatal period and submitted to hormonal stimulus in adulthood. Blood was collected to obtain hormone concentrations. Slides stained with hematoxylin & eosin, and picrosirius were subjected to fractal, stereological, morphometric, and collagen quantification analysis. I3C decreased the plasma dihydrotestosterone levels, and both phytochemicals increased the plasma estrogen levels. Unlike phytochemicals, BPA did not alter any of the parameters evaluated. GEN reduced the epithelial height, while I3C increased the fractal dimension and stromal collagen. Although BPA did not alter the prostate morphology, the phytochemicals provided beneficial effects for the prostate histological organization in adult animals subjected to hormonal stimulus.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-07-29T15:13:27Z
2023-07-29T15:13:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/09603123.2022.2140127
International Journal of Environmental Health Research.
1369-1619
0960-3123
http://hdl.handle.net/11449/249342
10.1080/09603123.2022.2140127
2-s2.0-85141414238
url http://dx.doi.org/10.1080/09603123.2022.2140127
http://hdl.handle.net/11449/249342
identifier_str_mv International Journal of Environmental Health Research.
1369-1619
0960-3123
10.1080/09603123.2022.2140127
2-s2.0-85141414238
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Environmental Health Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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