Fator de crescimento nervoso em cola de fibrina no reparo término-lateral de nervos em ratos

• Autor(a) principal: e Silva, Daniel Nunes
• Data de Publicação: 2012
• Outros Autores: da Silva, Andréia Conceição Milan Brochado Antoniolli, Aydos, Ricardo Dutra, Viterbo, Fausto [UNESP], Pontes, Elenir Rose Jardim Cury, Odashiro, Danilo Nakao, de Castro, Rafael José, Augusto, Diogo Gomes
• Tipo de documento: Artigo
• Idioma: eng; por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/S0102-86502012000400008; http://hdl.handle.net/11449/73326
• topic: Fibrin tissue adhesive; Microsurgery; Rats; Suture techniques; fibrin glue; nerve growth factor; animal experiment; controlled study; end to side anastomosis; motor performance; nerve fiber regeneration; nerve growth; nerve regeneration; nerve transection; nonhuman; rat; tibial nerve; tibialis anterior muscle; Anastomosis, Surgical; Animals; Fibrin Tissue Adhesive; Male; Nerve Endings; Nerve Growth Factor; Nerve Regeneration; Peroneal Nerve; Rats, Wistar; Tissue Adhesives

Purpose: To determine the effects of end-to-side nerve repair performed only with fibrin glue containing nerve growth in rats. Methods: Seventy two Wistar rats were divided into six equal groups: group A was not submitted to nerve section; group B was submitted to nerve fibular section only. The others groups had the nerve fibular sectioned and then repaired in the lateral surface of an intact tibial nerve, with different procedures: group C: ETS with sutures; group D: ETS with sutures and NGF; group E: ETS with FG only; group F: ETS with FG containing NGF. The motor function was accompanied and the tibial muscle mass, the number and diameter of muscular fibers and regenerated axons were measured. Results: All the analyzed variables did not show any differences among the four operated groups (p>0.05), which were statistically superior to group B (p<0.05), but inferior to group A (p>0.05). Conclusion: The end-to-side nerve repair presented the same recovery pattern, independent from the repair used, showing that the addition of nerve growth factor in fibrin glue was not enough for the results potentiating.