A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2019/3524207 http://hdl.handle.net/11449/189134 |
Resumo: | Objective. To evaluate the effect of chemically modified tetracycline-3 (CMT-3) and simvastatin on tooth relapse after orthodontic movement in rats using a novel analysis method employing high-resolution micro-CT (Micro-CT) images. In addition, the correlation between bone density and orthodontic relapse was also evaluated for each experimental group. Methods. Forty adult male Wistar rats had stainless steel springs installed on their left upper first molars in order to generate tooth movement for 18 days. After this initial period, the animals were divided into three groups: (1) 30 mg/kg of CMT-3; (2) 5 mg/kg of simvastatin; and (3) 0.5% carboxymethylcellulose, and each group was treated for 20 days. Micro-CT images were analyzed (conventional method and 3D reconstruction) on the 7th and 18th days following spring fixation and finally, 20 days after treatment either with CMT-3 or simvastatin (38th day). Bone mineral density (BMD) of the mesial and distal roots of the upper first molar was also analyzed. Results. The difference was statistically significant between the groups as to recurrence (p = 0.048), and the post hoc test identified the value of p = 0.007 between the control group and the CMT-3 group. Simvastatin was not able to inhibit tooth relapse. The bone mineral densities of both the mesial and distal roots were different between the three groups, after the 20th day of drug use (p = 0001 and p < 0001). Conclusion. Our findings support the initial evidence that CMT-3 is able to prevent relapse after tooth movement. Future trials in humans should evaluate such treatment as a promising approach to preventing this common phenomenon. Clinical Relevance. Considering the results obtained, CMT- 3 can be used to avoid relapse after tooth movement. |
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spelling |
A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental StudyObjective. To evaluate the effect of chemically modified tetracycline-3 (CMT-3) and simvastatin on tooth relapse after orthodontic movement in rats using a novel analysis method employing high-resolution micro-CT (Micro-CT) images. In addition, the correlation between bone density and orthodontic relapse was also evaluated for each experimental group. Methods. Forty adult male Wistar rats had stainless steel springs installed on their left upper first molars in order to generate tooth movement for 18 days. After this initial period, the animals were divided into three groups: (1) 30 mg/kg of CMT-3; (2) 5 mg/kg of simvastatin; and (3) 0.5% carboxymethylcellulose, and each group was treated for 20 days. Micro-CT images were analyzed (conventional method and 3D reconstruction) on the 7th and 18th days following spring fixation and finally, 20 days after treatment either with CMT-3 or simvastatin (38th day). Bone mineral density (BMD) of the mesial and distal roots of the upper first molar was also analyzed. Results. The difference was statistically significant between the groups as to recurrence (p = 0.048), and the post hoc test identified the value of p = 0.007 between the control group and the CMT-3 group. Simvastatin was not able to inhibit tooth relapse. The bone mineral densities of both the mesial and distal roots were different between the three groups, after the 20th day of drug use (p = 0001 and p < 0001). Conclusion. Our findings support the initial evidence that CMT-3 is able to prevent relapse after tooth movement. Future trials in humans should evaluate such treatment as a promising approach to preventing this common phenomenon. Clinical Relevance. Considering the results obtained, CMT- 3 can be used to avoid relapse after tooth movement.Department of Medical Sciences University of Brasília (UnB) Campus Darcy RibeiroDepartment of Surgery and Integrated Clinic University of Aracatuba Dental School (UNESP), 1193 Jose Bonifacio StreetDepartment of Genetics and Morphology Institute of Biological Sciences University of Brasilia (UnB) Campus Darcy Ribeiro, Asa NorteDepartment of Medicine Brasilia Children's Hospital Brasilia, St. de Habitações Individuais Sul QI 15Department of Farmacology, 126 Tessalia Vieira de Camargo StreetDepartment of Surgery and Integrated Clinic University of Aracatuba Dental School (UNESP), 1193 Jose Bonifacio StreetUniversity of Brasília (UnB)Universidade Estadual Paulista (Unesp)University of Brasilia (UnB)Brasilia Children's Hospital BrasiliaUniversidade Estadual de Campinas (UNICAMP)Vieira, Giovanni ModestoFalcao, Denise PinheiroDe Queiroz, Sormani Bento Fernandes [UNESP]De Lima, Valthierre Nunes [UNESP]Bentes De Azevedo, RicardoTiziane, ValdenizeMoreno, HeitorAmorim, Rivadavio2019-10-06T16:30:55Z2019-10-06T16:30:55Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1155/2019/3524207International Journal of Dentistry, v. 2019.1687-87361687-8728http://hdl.handle.net/11449/18913410.1155/2019/35242072-s2.0-85065791538Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Dentistryinfo:eu-repo/semantics/openAccess2021-10-23T17:30:20Zoai:repositorio.unesp.br:11449/189134Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T17:30:20Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study |
title |
A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study |
spellingShingle |
A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study Vieira, Giovanni Modesto |
title_short |
A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study |
title_full |
A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study |
title_fullStr |
A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study |
title_full_unstemmed |
A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study |
title_sort |
A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study |
author |
Vieira, Giovanni Modesto |
author_facet |
Vieira, Giovanni Modesto Falcao, Denise Pinheiro De Queiroz, Sormani Bento Fernandes [UNESP] De Lima, Valthierre Nunes [UNESP] Bentes De Azevedo, Ricardo Tiziane, Valdenize Moreno, Heitor Amorim, Rivadavio |
author_role |
author |
author2 |
Falcao, Denise Pinheiro De Queiroz, Sormani Bento Fernandes [UNESP] De Lima, Valthierre Nunes [UNESP] Bentes De Azevedo, Ricardo Tiziane, Valdenize Moreno, Heitor Amorim, Rivadavio |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
University of Brasília (UnB) Universidade Estadual Paulista (Unesp) University of Brasilia (UnB) Brasilia Children's Hospital Brasilia Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Vieira, Giovanni Modesto Falcao, Denise Pinheiro De Queiroz, Sormani Bento Fernandes [UNESP] De Lima, Valthierre Nunes [UNESP] Bentes De Azevedo, Ricardo Tiziane, Valdenize Moreno, Heitor Amorim, Rivadavio |
description |
Objective. To evaluate the effect of chemically modified tetracycline-3 (CMT-3) and simvastatin on tooth relapse after orthodontic movement in rats using a novel analysis method employing high-resolution micro-CT (Micro-CT) images. In addition, the correlation between bone density and orthodontic relapse was also evaluated for each experimental group. Methods. Forty adult male Wistar rats had stainless steel springs installed on their left upper first molars in order to generate tooth movement for 18 days. After this initial period, the animals were divided into three groups: (1) 30 mg/kg of CMT-3; (2) 5 mg/kg of simvastatin; and (3) 0.5% carboxymethylcellulose, and each group was treated for 20 days. Micro-CT images were analyzed (conventional method and 3D reconstruction) on the 7th and 18th days following spring fixation and finally, 20 days after treatment either with CMT-3 or simvastatin (38th day). Bone mineral density (BMD) of the mesial and distal roots of the upper first molar was also analyzed. Results. The difference was statistically significant between the groups as to recurrence (p = 0.048), and the post hoc test identified the value of p = 0.007 between the control group and the CMT-3 group. Simvastatin was not able to inhibit tooth relapse. The bone mineral densities of both the mesial and distal roots were different between the three groups, after the 20th day of drug use (p = 0001 and p < 0001). Conclusion. Our findings support the initial evidence that CMT-3 is able to prevent relapse after tooth movement. Future trials in humans should evaluate such treatment as a promising approach to preventing this common phenomenon. Clinical Relevance. Considering the results obtained, CMT- 3 can be used to avoid relapse after tooth movement. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:30:55Z 2019-10-06T16:30:55Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2019/3524207 International Journal of Dentistry, v. 2019. 1687-8736 1687-8728 http://hdl.handle.net/11449/189134 10.1155/2019/3524207 2-s2.0-85065791538 |
url |
http://dx.doi.org/10.1155/2019/3524207 http://hdl.handle.net/11449/189134 |
identifier_str_mv |
International Journal of Dentistry, v. 2019. 1687-8736 1687-8728 10.1155/2019/3524207 2-s2.0-85065791538 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Dentistry |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1803045980549939200 |