Nasal polyposis in cystic fibrosis: follow-up of children and adolescents for a 3-year period

Detalhes bibliográficos
Autor(a) principal: Theresa Weber, Silke Anna [UNESP]
Data de Publicação: 2017
Outros Autores: Iyomasa, Renata Mizusaki [UNESP], Correa, Camila de Castro [UNESP], Mafra Florentino, Wellington Novais [UNESP], Ferrari, Giesela Fleischer [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.bjorl.2016.09.005
http://hdl.handle.net/11449/163597
Resumo: Introduction : Nasal polyposis is often found in patients with cystic fibrosis. Objective : To assess the incidence of nasal polyposis, the response to medical treatment, recurrence and the need for surgical intervention in children and adolescents with cystic fibrosis during a three-year follow-up. Methods : Clinical symptoms (pulmonary, pancreatic insufficiency, malnutrition, nasal obstruction), two positive sweat chloride tests, and genotype findings in 23 patients with cystic fibrosis were analyzed. All patients underwent nasal endoscopy every 12 months from January 2005 to December 2007, to assess the presence and grade of Nasal Polyps. Nasal polyposis, when present, were treated with topical corticosteroids for 6-12 months, with progress being evaluated within the 3 years of follow-up. Results : In the first evaluation, nasal polyposis was diagnosed in 30.43% of patients (3 bilateral and 4 unilateral), recurrent pneumonia in 82.6%, pancreatic insufficiency in 87%, and malnutrition in 74%. The presence of nasal polyposis was not associated with chloride values in the sweat, genotype, clinical signs of severity of cystic fibrosis, or nasal symptoms. In the three-year period of follow up, 13 patients (56.52%) had at least one event of polyposis, with the youngest being diagnosed at 32 months of age. Only one patient underwent surgery (polypectomy), and there was one diagnosis of nasopharyngeal carcinoma. Conclusion : The study showed a high incidence of nasal polyposis. Monitoring through routine endoscopy in patients with cystic fibrosis, even in the absence of nasal symptoms, is highly recommended. The therapy with topical corticosteroids achieved good results. Thus, an interaction between pediatricians and otolaryngologists is necessary. (C) 2016 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.
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spelling Nasal polyposis in cystic fibrosis: follow-up of children and adolescents for a 3-year periodPolyposisCystic fibrosisDiagnosisEndoscopyTherapyIntroduction : Nasal polyposis is often found in patients with cystic fibrosis. Objective : To assess the incidence of nasal polyposis, the response to medical treatment, recurrence and the need for surgical intervention in children and adolescents with cystic fibrosis during a three-year follow-up. Methods : Clinical symptoms (pulmonary, pancreatic insufficiency, malnutrition, nasal obstruction), two positive sweat chloride tests, and genotype findings in 23 patients with cystic fibrosis were analyzed. All patients underwent nasal endoscopy every 12 months from January 2005 to December 2007, to assess the presence and grade of Nasal Polyps. Nasal polyposis, when present, were treated with topical corticosteroids for 6-12 months, with progress being evaluated within the 3 years of follow-up. Results : In the first evaluation, nasal polyposis was diagnosed in 30.43% of patients (3 bilateral and 4 unilateral), recurrent pneumonia in 82.6%, pancreatic insufficiency in 87%, and malnutrition in 74%. The presence of nasal polyposis was not associated with chloride values in the sweat, genotype, clinical signs of severity of cystic fibrosis, or nasal symptoms. In the three-year period of follow up, 13 patients (56.52%) had at least one event of polyposis, with the youngest being diagnosed at 32 months of age. Only one patient underwent surgery (polypectomy), and there was one diagnosis of nasopharyngeal carcinoma. Conclusion : The study showed a high incidence of nasal polyposis. Monitoring through routine endoscopy in patients with cystic fibrosis, even in the absence of nasal symptoms, is highly recommended. The therapy with topical corticosteroids achieved good results. Thus, an interaction between pediatricians and otolaryngologists is necessary. (C) 2016 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estudual Paulista Julio de Mesquita Filho, Fac Med Botucatu, Dept Oftalmol Otorrinolaringol & Cirurgia Cabeca, Botucatu, SP, BrazilUniv Estudual Paulista Julio de Mesquita Filho, Fac Med Botucatu, Dept Pediat, Botucatu, SP, BrazilUniv Estudual Paulista Julio de Mesquita Filho, Fac Med Botucatu, Dept Oftalmol Otorrinolaringol & Cirurgia Cabeca, Botucatu, SP, BrazilUniv Estudual Paulista Julio de Mesquita Filho, Fac Med Botucatu, Dept Pediat, Botucatu, SP, BrazilFAPESP: 2010/11064-1Assoc Brasileira Otorrinolaringologia & Cirurgia CervicofacialUniversidade Estadual Paulista (Unesp)Theresa Weber, Silke Anna [UNESP]Iyomasa, Renata Mizusaki [UNESP]Correa, Camila de Castro [UNESP]Mafra Florentino, Wellington Novais [UNESP]Ferrari, Giesela Fleischer [UNESP]2018-11-26T17:42:41Z2018-11-26T17:42:41Z2017-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article677-682application/pdfhttp://dx.doi.org/10.1016/j.bjorl.2016.09.005Brazilian Journal Of Otorhinolaryngology. Sao Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 83, n. 6, p. 677-682, 2017.1808-8694http://hdl.handle.net/11449/16359710.1016/j.bjorl.2016.09.005WOS:000417392200012WOS000417392200012.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal Of Otorhinolaryngology0,443info:eu-repo/semantics/openAccess2023-12-14T06:22:16Zoai:repositorio.unesp.br:11449/163597Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-14T06:22:16Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Nasal polyposis in cystic fibrosis: follow-up of children and adolescents for a 3-year period
title Nasal polyposis in cystic fibrosis: follow-up of children and adolescents for a 3-year period
spellingShingle Nasal polyposis in cystic fibrosis: follow-up of children and adolescents for a 3-year period
Theresa Weber, Silke Anna [UNESP]
Polyposis
Cystic fibrosis
Diagnosis
Endoscopy
Therapy
title_short Nasal polyposis in cystic fibrosis: follow-up of children and adolescents for a 3-year period
title_full Nasal polyposis in cystic fibrosis: follow-up of children and adolescents for a 3-year period
title_fullStr Nasal polyposis in cystic fibrosis: follow-up of children and adolescents for a 3-year period
title_full_unstemmed Nasal polyposis in cystic fibrosis: follow-up of children and adolescents for a 3-year period
title_sort Nasal polyposis in cystic fibrosis: follow-up of children and adolescents for a 3-year period
author Theresa Weber, Silke Anna [UNESP]
author_facet Theresa Weber, Silke Anna [UNESP]
Iyomasa, Renata Mizusaki [UNESP]
Correa, Camila de Castro [UNESP]
Mafra Florentino, Wellington Novais [UNESP]
Ferrari, Giesela Fleischer [UNESP]
author_role author
author2 Iyomasa, Renata Mizusaki [UNESP]
Correa, Camila de Castro [UNESP]
Mafra Florentino, Wellington Novais [UNESP]
Ferrari, Giesela Fleischer [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Theresa Weber, Silke Anna [UNESP]
Iyomasa, Renata Mizusaki [UNESP]
Correa, Camila de Castro [UNESP]
Mafra Florentino, Wellington Novais [UNESP]
Ferrari, Giesela Fleischer [UNESP]
dc.subject.por.fl_str_mv Polyposis
Cystic fibrosis
Diagnosis
Endoscopy
Therapy
topic Polyposis
Cystic fibrosis
Diagnosis
Endoscopy
Therapy
description Introduction : Nasal polyposis is often found in patients with cystic fibrosis. Objective : To assess the incidence of nasal polyposis, the response to medical treatment, recurrence and the need for surgical intervention in children and adolescents with cystic fibrosis during a three-year follow-up. Methods : Clinical symptoms (pulmonary, pancreatic insufficiency, malnutrition, nasal obstruction), two positive sweat chloride tests, and genotype findings in 23 patients with cystic fibrosis were analyzed. All patients underwent nasal endoscopy every 12 months from January 2005 to December 2007, to assess the presence and grade of Nasal Polyps. Nasal polyposis, when present, were treated with topical corticosteroids for 6-12 months, with progress being evaluated within the 3 years of follow-up. Results : In the first evaluation, nasal polyposis was diagnosed in 30.43% of patients (3 bilateral and 4 unilateral), recurrent pneumonia in 82.6%, pancreatic insufficiency in 87%, and malnutrition in 74%. The presence of nasal polyposis was not associated with chloride values in the sweat, genotype, clinical signs of severity of cystic fibrosis, or nasal symptoms. In the three-year period of follow up, 13 patients (56.52%) had at least one event of polyposis, with the youngest being diagnosed at 32 months of age. Only one patient underwent surgery (polypectomy), and there was one diagnosis of nasopharyngeal carcinoma. Conclusion : The study showed a high incidence of nasal polyposis. Monitoring through routine endoscopy in patients with cystic fibrosis, even in the absence of nasal symptoms, is highly recommended. The therapy with topical corticosteroids achieved good results. Thus, an interaction between pediatricians and otolaryngologists is necessary. (C) 2016 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-01
2018-11-26T17:42:41Z
2018-11-26T17:42:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.bjorl.2016.09.005
Brazilian Journal Of Otorhinolaryngology. Sao Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 83, n. 6, p. 677-682, 2017.
1808-8694
http://hdl.handle.net/11449/163597
10.1016/j.bjorl.2016.09.005
WOS:000417392200012
WOS000417392200012.pdf
url http://dx.doi.org/10.1016/j.bjorl.2016.09.005
http://hdl.handle.net/11449/163597
identifier_str_mv Brazilian Journal Of Otorhinolaryngology. Sao Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 83, n. 6, p. 677-682, 2017.
1808-8694
10.1016/j.bjorl.2016.09.005
WOS:000417392200012
WOS000417392200012.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal Of Otorhinolaryngology
0,443
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 677-682
application/pdf
dc.publisher.none.fl_str_mv Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
publisher.none.fl_str_mv Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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