Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1177/1545968320924430 http://hdl.handle.net/11449/201804 |
Resumo: | Background. Although dopaminergic medication improves dual task walking in people with Parkinson disease (PD), the underlying neural mechanisms are not yet fully understood. As prefrontal cognitive resources are involved in dual task walking, evaluation of the prefrontal cortex (PFC) is required. Objective. To investigate the effect of dopaminergic medication on PFC activity and gait parameters during dual task walking in people with PD. Methods. A total of 20 individuals with PD (69.8 ± 5.9 years) and 30 healthy older people (68.0 ± 5.6 years) performed 2 walking conditions: single and dual task (walking while performing a digit vigilance task). A mobile functional near infrared spectroscopy system and an electronic sensor carpet were used to analyze PFC activation and gait parameters, respectively. Relative concentrations of oxygenated hemoglobin (HbO2) from the left and right PFC were measured. Results. People with PD in the off state did not present changes in HbO2 level in the left PFC across walking conditions. In contrast, in the on state, they presented increased HbO2 levels during dual task compared with single task. Regardless of medication state, people with PD presented increased HbO2 levels in the right PFC during dual task walking compared with single task. The control group demonstrated increased PFC activity in both hemispheres during dual task compared with single task. People with PD showed increases in both step length and velocity in the on state compared with the off state. Conclusions. PD limits the activation of the left PFC during dual task walking, and dopaminergic medication facilitates its recruitment. |
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Repositório Institucional da UNESP |
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Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson DiseasecognitiondopaminefNIRSgaitParkinson diseaseBackground. Although dopaminergic medication improves dual task walking in people with Parkinson disease (PD), the underlying neural mechanisms are not yet fully understood. As prefrontal cognitive resources are involved in dual task walking, evaluation of the prefrontal cortex (PFC) is required. Objective. To investigate the effect of dopaminergic medication on PFC activity and gait parameters during dual task walking in people with PD. Methods. A total of 20 individuals with PD (69.8 ± 5.9 years) and 30 healthy older people (68.0 ± 5.6 years) performed 2 walking conditions: single and dual task (walking while performing a digit vigilance task). A mobile functional near infrared spectroscopy system and an electronic sensor carpet were used to analyze PFC activation and gait parameters, respectively. Relative concentrations of oxygenated hemoglobin (HbO2) from the left and right PFC were measured. Results. People with PD in the off state did not present changes in HbO2 level in the left PFC across walking conditions. In contrast, in the on state, they presented increased HbO2 levels during dual task compared with single task. Regardless of medication state, people with PD presented increased HbO2 levels in the right PFC during dual task walking compared with single task. The control group demonstrated increased PFC activity in both hemispheres during dual task compared with single task. People with PD showed increases in both step length and velocity in the on state compared with the off state. Conclusions. PD limits the activation of the left PFC during dual task walking, and dopaminergic medication facilitates its recruitment.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Institute of Biosciences Posture and Gait Studies Laboratory (LEPLO) São Paulo State University (UNESP)Graduate Program in Movement Sciences São Paulo State University (UNESP)Institute of Biosciences Posture and Gait Studies Laboratory (LEPLO) São Paulo State University (UNESP)Graduate Program in Movement Sciences São Paulo State University (UNESP)FAPESP: 2014/22308-0FAPESP: 2016/21499-1CNPq: 429549/2018-0CAPES: Finance Code 001Universidade Estadual Paulista (Unesp)Orcioli-Silva, Diego [UNESP]Vitório, Rodrigo [UNESP]Nóbrega-Sousa, Priscila [UNESP]da Conceição, Núbia Ribeiro [UNESP]Beretta, Victor Spiandor [UNESP]Lirani-Silva, Ellen [UNESP]Gobbi, Lilian Teresa Bucken [UNESP]2020-12-12T02:42:17Z2020-12-12T02:42:17Z2020-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article589-599http://dx.doi.org/10.1177/1545968320924430Neurorehabilitation and Neural Repair, v. 34, n. 7, p. 589-599, 2020.1552-68441545-9683http://hdl.handle.net/11449/20180410.1177/15459683209244302-s2.0-85085325016Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNeurorehabilitation and Neural Repairinfo:eu-repo/semantics/openAccess2021-10-22T22:17:26Zoai:repositorio.unesp.br:11449/201804Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:54:57.377106Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease |
title |
Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease |
spellingShingle |
Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease Orcioli-Silva, Diego [UNESP] cognition dopamine fNIRS gait Parkinson disease |
title_short |
Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease |
title_full |
Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease |
title_fullStr |
Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease |
title_full_unstemmed |
Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease |
title_sort |
Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease |
author |
Orcioli-Silva, Diego [UNESP] |
author_facet |
Orcioli-Silva, Diego [UNESP] Vitório, Rodrigo [UNESP] Nóbrega-Sousa, Priscila [UNESP] da Conceição, Núbia Ribeiro [UNESP] Beretta, Victor Spiandor [UNESP] Lirani-Silva, Ellen [UNESP] Gobbi, Lilian Teresa Bucken [UNESP] |
author_role |
author |
author2 |
Vitório, Rodrigo [UNESP] Nóbrega-Sousa, Priscila [UNESP] da Conceição, Núbia Ribeiro [UNESP] Beretta, Victor Spiandor [UNESP] Lirani-Silva, Ellen [UNESP] Gobbi, Lilian Teresa Bucken [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Orcioli-Silva, Diego [UNESP] Vitório, Rodrigo [UNESP] Nóbrega-Sousa, Priscila [UNESP] da Conceição, Núbia Ribeiro [UNESP] Beretta, Victor Spiandor [UNESP] Lirani-Silva, Ellen [UNESP] Gobbi, Lilian Teresa Bucken [UNESP] |
dc.subject.por.fl_str_mv |
cognition dopamine fNIRS gait Parkinson disease |
topic |
cognition dopamine fNIRS gait Parkinson disease |
description |
Background. Although dopaminergic medication improves dual task walking in people with Parkinson disease (PD), the underlying neural mechanisms are not yet fully understood. As prefrontal cognitive resources are involved in dual task walking, evaluation of the prefrontal cortex (PFC) is required. Objective. To investigate the effect of dopaminergic medication on PFC activity and gait parameters during dual task walking in people with PD. Methods. A total of 20 individuals with PD (69.8 ± 5.9 years) and 30 healthy older people (68.0 ± 5.6 years) performed 2 walking conditions: single and dual task (walking while performing a digit vigilance task). A mobile functional near infrared spectroscopy system and an electronic sensor carpet were used to analyze PFC activation and gait parameters, respectively. Relative concentrations of oxygenated hemoglobin (HbO2) from the left and right PFC were measured. Results. People with PD in the off state did not present changes in HbO2 level in the left PFC across walking conditions. In contrast, in the on state, they presented increased HbO2 levels during dual task compared with single task. Regardless of medication state, people with PD presented increased HbO2 levels in the right PFC during dual task walking compared with single task. The control group demonstrated increased PFC activity in both hemispheres during dual task compared with single task. People with PD showed increases in both step length and velocity in the on state compared with the off state. Conclusions. PD limits the activation of the left PFC during dual task walking, and dopaminergic medication facilitates its recruitment. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:42:17Z 2020-12-12T02:42:17Z 2020-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1177/1545968320924430 Neurorehabilitation and Neural Repair, v. 34, n. 7, p. 589-599, 2020. 1552-6844 1545-9683 http://hdl.handle.net/11449/201804 10.1177/1545968320924430 2-s2.0-85085325016 |
url |
http://dx.doi.org/10.1177/1545968320924430 http://hdl.handle.net/11449/201804 |
identifier_str_mv |
Neurorehabilitation and Neural Repair, v. 34, n. 7, p. 589-599, 2020. 1552-6844 1545-9683 10.1177/1545968320924430 2-s2.0-85085325016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neurorehabilitation and Neural Repair |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
589-599 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128720353886208 |