Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease

Detalhes bibliográficos
Autor(a) principal: Orcioli-Silva, Diego [UNESP]
Data de Publicação: 2020
Outros Autores: Vitório, Rodrigo [UNESP], Nóbrega-Sousa, Priscila [UNESP], da Conceição, Núbia Ribeiro [UNESP], Beretta, Victor Spiandor [UNESP], Lirani-Silva, Ellen [UNESP], Gobbi, Lilian Teresa Bucken [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1177/1545968320924430
http://hdl.handle.net/11449/201804
Resumo: Background. Although dopaminergic medication improves dual task walking in people with Parkinson disease (PD), the underlying neural mechanisms are not yet fully understood. As prefrontal cognitive resources are involved in dual task walking, evaluation of the prefrontal cortex (PFC) is required. Objective. To investigate the effect of dopaminergic medication on PFC activity and gait parameters during dual task walking in people with PD. Methods. A total of 20 individuals with PD (69.8 ± 5.9 years) and 30 healthy older people (68.0 ± 5.6 years) performed 2 walking conditions: single and dual task (walking while performing a digit vigilance task). A mobile functional near infrared spectroscopy system and an electronic sensor carpet were used to analyze PFC activation and gait parameters, respectively. Relative concentrations of oxygenated hemoglobin (HbO2) from the left and right PFC were measured. Results. People with PD in the off state did not present changes in HbO2 level in the left PFC across walking conditions. In contrast, in the on state, they presented increased HbO2 levels during dual task compared with single task. Regardless of medication state, people with PD presented increased HbO2 levels in the right PFC during dual task walking compared with single task. The control group demonstrated increased PFC activity in both hemispheres during dual task compared with single task. People with PD showed increases in both step length and velocity in the on state compared with the off state. Conclusions. PD limits the activation of the left PFC during dual task walking, and dopaminergic medication facilitates its recruitment.
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spelling Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson DiseasecognitiondopaminefNIRSgaitParkinson diseaseBackground. Although dopaminergic medication improves dual task walking in people with Parkinson disease (PD), the underlying neural mechanisms are not yet fully understood. As prefrontal cognitive resources are involved in dual task walking, evaluation of the prefrontal cortex (PFC) is required. Objective. To investigate the effect of dopaminergic medication on PFC activity and gait parameters during dual task walking in people with PD. Methods. A total of 20 individuals with PD (69.8 ± 5.9 years) and 30 healthy older people (68.0 ± 5.6 years) performed 2 walking conditions: single and dual task (walking while performing a digit vigilance task). A mobile functional near infrared spectroscopy system and an electronic sensor carpet were used to analyze PFC activation and gait parameters, respectively. Relative concentrations of oxygenated hemoglobin (HbO2) from the left and right PFC were measured. Results. People with PD in the off state did not present changes in HbO2 level in the left PFC across walking conditions. In contrast, in the on state, they presented increased HbO2 levels during dual task compared with single task. Regardless of medication state, people with PD presented increased HbO2 levels in the right PFC during dual task walking compared with single task. The control group demonstrated increased PFC activity in both hemispheres during dual task compared with single task. People with PD showed increases in both step length and velocity in the on state compared with the off state. Conclusions. PD limits the activation of the left PFC during dual task walking, and dopaminergic medication facilitates its recruitment.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Institute of Biosciences Posture and Gait Studies Laboratory (LEPLO) São Paulo State University (UNESP)Graduate Program in Movement Sciences São Paulo State University (UNESP)Institute of Biosciences Posture and Gait Studies Laboratory (LEPLO) São Paulo State University (UNESP)Graduate Program in Movement Sciences São Paulo State University (UNESP)FAPESP: 2014/22308-0FAPESP: 2016/21499-1CNPq: 429549/2018-0CAPES: Finance Code 001Universidade Estadual Paulista (Unesp)Orcioli-Silva, Diego [UNESP]Vitório, Rodrigo [UNESP]Nóbrega-Sousa, Priscila [UNESP]da Conceição, Núbia Ribeiro [UNESP]Beretta, Victor Spiandor [UNESP]Lirani-Silva, Ellen [UNESP]Gobbi, Lilian Teresa Bucken [UNESP]2020-12-12T02:42:17Z2020-12-12T02:42:17Z2020-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article589-599http://dx.doi.org/10.1177/1545968320924430Neurorehabilitation and Neural Repair, v. 34, n. 7, p. 589-599, 2020.1552-68441545-9683http://hdl.handle.net/11449/20180410.1177/15459683209244302-s2.0-85085325016Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNeurorehabilitation and Neural Repairinfo:eu-repo/semantics/openAccess2021-10-22T22:17:26Zoai:repositorio.unesp.br:11449/201804Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:54:57.377106Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease
title Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease
spellingShingle Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease
Orcioli-Silva, Diego [UNESP]
cognition
dopamine
fNIRS
gait
Parkinson disease
title_short Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease
title_full Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease
title_fullStr Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease
title_full_unstemmed Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease
title_sort Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease
author Orcioli-Silva, Diego [UNESP]
author_facet Orcioli-Silva, Diego [UNESP]
Vitório, Rodrigo [UNESP]
Nóbrega-Sousa, Priscila [UNESP]
da Conceição, Núbia Ribeiro [UNESP]
Beretta, Victor Spiandor [UNESP]
Lirani-Silva, Ellen [UNESP]
Gobbi, Lilian Teresa Bucken [UNESP]
author_role author
author2 Vitório, Rodrigo [UNESP]
Nóbrega-Sousa, Priscila [UNESP]
da Conceição, Núbia Ribeiro [UNESP]
Beretta, Victor Spiandor [UNESP]
Lirani-Silva, Ellen [UNESP]
Gobbi, Lilian Teresa Bucken [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Orcioli-Silva, Diego [UNESP]
Vitório, Rodrigo [UNESP]
Nóbrega-Sousa, Priscila [UNESP]
da Conceição, Núbia Ribeiro [UNESP]
Beretta, Victor Spiandor [UNESP]
Lirani-Silva, Ellen [UNESP]
Gobbi, Lilian Teresa Bucken [UNESP]
dc.subject.por.fl_str_mv cognition
dopamine
fNIRS
gait
Parkinson disease
topic cognition
dopamine
fNIRS
gait
Parkinson disease
description Background. Although dopaminergic medication improves dual task walking in people with Parkinson disease (PD), the underlying neural mechanisms are not yet fully understood. As prefrontal cognitive resources are involved in dual task walking, evaluation of the prefrontal cortex (PFC) is required. Objective. To investigate the effect of dopaminergic medication on PFC activity and gait parameters during dual task walking in people with PD. Methods. A total of 20 individuals with PD (69.8 ± 5.9 years) and 30 healthy older people (68.0 ± 5.6 years) performed 2 walking conditions: single and dual task (walking while performing a digit vigilance task). A mobile functional near infrared spectroscopy system and an electronic sensor carpet were used to analyze PFC activation and gait parameters, respectively. Relative concentrations of oxygenated hemoglobin (HbO2) from the left and right PFC were measured. Results. People with PD in the off state did not present changes in HbO2 level in the left PFC across walking conditions. In contrast, in the on state, they presented increased HbO2 levels during dual task compared with single task. Regardless of medication state, people with PD presented increased HbO2 levels in the right PFC during dual task walking compared with single task. The control group demonstrated increased PFC activity in both hemispheres during dual task compared with single task. People with PD showed increases in both step length and velocity in the on state compared with the off state. Conclusions. PD limits the activation of the left PFC during dual task walking, and dopaminergic medication facilitates its recruitment.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:42:17Z
2020-12-12T02:42:17Z
2020-07-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1177/1545968320924430
Neurorehabilitation and Neural Repair, v. 34, n. 7, p. 589-599, 2020.
1552-6844
1545-9683
http://hdl.handle.net/11449/201804
10.1177/1545968320924430
2-s2.0-85085325016
url http://dx.doi.org/10.1177/1545968320924430
http://hdl.handle.net/11449/201804
identifier_str_mv Neurorehabilitation and Neural Repair, v. 34, n. 7, p. 589-599, 2020.
1552-6844
1545-9683
10.1177/1545968320924430
2-s2.0-85085325016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Neurorehabilitation and Neural Repair
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 589-599
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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