COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3389/ti.2022.10375 http://hdl.handle.net/11449/241535 |
Resumo: | Kidney transplant recipients present higher rates of pre-existing comorbidities, in particular diabetes mellitus (DM), hypertension, and cardiac disease. We aimed to verify the main risk factors related to DM that contribute to COVID-19 progression and mortality in a kidney transplant setting. From March to August 2020, we evaluated 300 kidney transplant recipients affected by COVID-19. We used propensity score matching (PSM) to estimate the impact of DM on COVID-19. After matching, all baseline characteristics were well balanced between those with and without DM (n = 100 in each group). Case fatality rate, the requirement of invasive mechanical ventilation (IMV), and acute kidney injury (AKI) were associated with previous fasting blood glucose, and C-reactive protein (CRP), and lactate dehydrogenase (LDH) levels on admission. These findings were similar in kidney transplant patients with and without DM. Glycemia on admission and estimated glomerular filtration rate (eGFR) either on admission or basal correlated to the need of IMV and development of AKI, respectively. Poor glycaemic control, eGFR, markers of inflammation (CRP) and tissue damage (LDH) were indicative of COVID-19 burden in kidney transplant recipients and may be useful tools for risk-stratifying this population, independently of the DM status, during the pandemic. |
id |
UNSP_242a83a335638b6ea4140beb955d27d5 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/241535 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching AnalysisCOVID-19diabetes mellituskidney transplantoutcomespropensity scoreKidney transplant recipients present higher rates of pre-existing comorbidities, in particular diabetes mellitus (DM), hypertension, and cardiac disease. We aimed to verify the main risk factors related to DM that contribute to COVID-19 progression and mortality in a kidney transplant setting. From March to August 2020, we evaluated 300 kidney transplant recipients affected by COVID-19. We used propensity score matching (PSM) to estimate the impact of DM on COVID-19. After matching, all baseline characteristics were well balanced between those with and without DM (n = 100 in each group). Case fatality rate, the requirement of invasive mechanical ventilation (IMV), and acute kidney injury (AKI) were associated with previous fasting blood glucose, and C-reactive protein (CRP), and lactate dehydrogenase (LDH) levels on admission. These findings were similar in kidney transplant patients with and without DM. Glycemia on admission and estimated glomerular filtration rate (eGFR) either on admission or basal correlated to the need of IMV and development of AKI, respectively. Poor glycaemic control, eGFR, markers of inflammation (CRP) and tissue damage (LDH) were indicative of COVID-19 burden in kidney transplant recipients and may be useful tools for risk-stratifying this population, independently of the DM status, during the pandemic.Hospital do RimNephrology Division Federal University of São PauloHospital Israelita Albert EinsteinDepartment of Internal Medicine Botucatu Medical School University of São Paulo StateDepartment of Internal Medicine Botucatu Medical School University of São Paulo StateHospital do RimUniversidade de São Paulo (USP)Hospital Israelita Albert EinsteinUniversidade Estadual Paulista (UNESP)Rangel, Érika B.de Lucena, Débora D.Aguiar-Brito, Isabellade Andrade, Luís Gustavo Modelli [UNESP]Veronese-Araújo, AlexandreCristelli, Marina P.Tedesco-Silva, HélioMedina-Pestana, José O.2023-03-01T21:08:42Z2023-03-01T21:08:42Z2022-07-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/ti.2022.10375Transplant International, v. 35.1432-22770934-0874http://hdl.handle.net/11449/24153510.3389/ti.2022.103752-s2.0-85136341873Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTransplant Internationalinfo:eu-repo/semantics/openAccess2024-08-14T17:23:10Zoai:repositorio.unesp.br:11449/241535Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:10Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis |
title |
COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis |
spellingShingle |
COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis Rangel, Érika B. COVID-19 diabetes mellitus kidney transplant outcomes propensity score |
title_short |
COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis |
title_full |
COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis |
title_fullStr |
COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis |
title_full_unstemmed |
COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis |
title_sort |
COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis |
author |
Rangel, Érika B. |
author_facet |
Rangel, Érika B. de Lucena, Débora D. Aguiar-Brito, Isabella de Andrade, Luís Gustavo Modelli [UNESP] Veronese-Araújo, Alexandre Cristelli, Marina P. Tedesco-Silva, Hélio Medina-Pestana, José O. |
author_role |
author |
author2 |
de Lucena, Débora D. Aguiar-Brito, Isabella de Andrade, Luís Gustavo Modelli [UNESP] Veronese-Araújo, Alexandre Cristelli, Marina P. Tedesco-Silva, Hélio Medina-Pestana, José O. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Hospital do Rim Universidade de São Paulo (USP) Hospital Israelita Albert Einstein Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Rangel, Érika B. de Lucena, Débora D. Aguiar-Brito, Isabella de Andrade, Luís Gustavo Modelli [UNESP] Veronese-Araújo, Alexandre Cristelli, Marina P. Tedesco-Silva, Hélio Medina-Pestana, José O. |
dc.subject.por.fl_str_mv |
COVID-19 diabetes mellitus kidney transplant outcomes propensity score |
topic |
COVID-19 diabetes mellitus kidney transplant outcomes propensity score |
description |
Kidney transplant recipients present higher rates of pre-existing comorbidities, in particular diabetes mellitus (DM), hypertension, and cardiac disease. We aimed to verify the main risk factors related to DM that contribute to COVID-19 progression and mortality in a kidney transplant setting. From March to August 2020, we evaluated 300 kidney transplant recipients affected by COVID-19. We used propensity score matching (PSM) to estimate the impact of DM on COVID-19. After matching, all baseline characteristics were well balanced between those with and without DM (n = 100 in each group). Case fatality rate, the requirement of invasive mechanical ventilation (IMV), and acute kidney injury (AKI) were associated with previous fasting blood glucose, and C-reactive protein (CRP), and lactate dehydrogenase (LDH) levels on admission. These findings were similar in kidney transplant patients with and without DM. Glycemia on admission and estimated glomerular filtration rate (eGFR) either on admission or basal correlated to the need of IMV and development of AKI, respectively. Poor glycaemic control, eGFR, markers of inflammation (CRP) and tissue damage (LDH) were indicative of COVID-19 burden in kidney transplant recipients and may be useful tools for risk-stratifying this population, independently of the DM status, during the pandemic. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-25 2023-03-01T21:08:42Z 2023-03-01T21:08:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3389/ti.2022.10375 Transplant International, v. 35. 1432-2277 0934-0874 http://hdl.handle.net/11449/241535 10.3389/ti.2022.10375 2-s2.0-85136341873 |
url |
http://dx.doi.org/10.3389/ti.2022.10375 http://hdl.handle.net/11449/241535 |
identifier_str_mv |
Transplant International, v. 35. 1432-2277 0934-0874 10.3389/ti.2022.10375 2-s2.0-85136341873 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Transplant International |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128153472729088 |