Avaliação da densidade radiográfica do reparo alveolar de ratos diabéticos tratados com o imunomodulador P-MAPA

• Autor(a) principal: Lazari, Priscilla Cardoso [UNESP]
• Data de Publicação: 2010
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/149420; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-26/000852092.pdf
• topic: Diabetes mellitus; Ratos; Complicações do diabetes

Diabetes mellitus is a complex metabolic disorder characterized by abnormal metabolism of carbohydrates, lipids and proteins. It is caused by total or partial deficiency of the synthesis of insulin by beta cells of islets of Langerhans in the pancreas. It is characterized mainly by the change of glucose metabolism. Its major oral complications include: hyposalivation, candidiasis, periodontal disease, periapical abscesses, hypocalcification dental, disorders in wound healing, delayed tooth eruption, burning mouth syndrome, gingival recession, increased incidence and severity of dental caries. Thinking of all the weaknesses presented in the diabetes and the possibility of an effective intervention immunomodulator P-MAPA, we decided to test it and see if the product adds physiological changes and reparations positive for this disease. We used 60 male Wistar rats two months of life, induced diabetes from STZ drug application (which destroys the beta cells of the pancreas), and from the induction was found three days at each level of insulin to proof of diabetic status was positive. The tooth extraction was performed on day 7 after induction of diabetes and the application of P-MAPA immunomodulator made subcutaneously every day until completed the three times of 7, 28, 45 to have euthanasia from this animals.The alveolus has been maintained in formalin until radiographic analysis and the Digora program had been done. When comparing the groups did not observe statistical differences in the times of 7 and 45 days. But in time of 28 days, we saw a statistical difference between groups Diabetes Treated and Control Treated. Comparing the time, all groups except the control groups treated, found statistical differences. In conclusion the methodology used in the study did not allow us to say which group had the best results...