Characterization of Luteal Blood Flow and Secretion of Progesterone in Mares Treated With Human Chorionic Gonadotropin for Ovulation Induction or During Early Diestrus
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jevs.2015.03.196 http://hdl.handle.net/11449/172004 |
Resumo: | Human chorionic gonadotropin (hCG) has been used to induce ovulation and as a luteotrophic agent in cattle. However, the effect of hCG therapy on the functional status of the equine corpus luteum (CL) is unclear. This study aimed to characterize the hemodynamic and secretory function of early CL of mares treated with different doses of hCG at distinct stages of the estrous cycle. Mares were assigned to nine experimental groups (n = 6 mares/group) according to dose of hCG and time of treatment. A single injection of one of three different doses of hCG (750, 1,500, or 2,500 IU) was performed in one of three distinct stages of the estrous cycle: preovulatory follicle ≥35mm, day of ovulation (D0), or 48hours after ovulation (D2). In addition, a control group treated with NaCl 0.9% was included in the study. The end points evaluated daily from D0 to D8 were area of the CL, luteal vascularity, number of colored pixels and total pixel intensity, and concentrations of plasma progesterone (P4). No effect (. P > .1) of dose or time of treatment was observed for any end point, within each day. Luteal area did not differ throughout the days (. P > .1), whereas Doppler parameters and concentrations of plasma P4 presented a progressive increase (. P < .05) after ovulation in all groups. Secretory function and luteal hemodynamic were not affected (. P > .1) by hCG dose and time of treatment. In conclusion, hCG therapy during estrus or early diestrus, at the doses tested, did not improve P4 secretion or luteal blood flow. |
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Characterization of Luteal Blood Flow and Secretion of Progesterone in Mares Treated With Human Chorionic Gonadotropin for Ovulation Induction or During Early DiestrusBlood flowCorpus luteumDiestrusDoppler ultrasonographyProgesteroneHuman chorionic gonadotropin (hCG) has been used to induce ovulation and as a luteotrophic agent in cattle. However, the effect of hCG therapy on the functional status of the equine corpus luteum (CL) is unclear. This study aimed to characterize the hemodynamic and secretory function of early CL of mares treated with different doses of hCG at distinct stages of the estrous cycle. Mares were assigned to nine experimental groups (n = 6 mares/group) according to dose of hCG and time of treatment. A single injection of one of three different doses of hCG (750, 1,500, or 2,500 IU) was performed in one of three distinct stages of the estrous cycle: preovulatory follicle ≥35mm, day of ovulation (D0), or 48hours after ovulation (D2). In addition, a control group treated with NaCl 0.9% was included in the study. The end points evaluated daily from D0 to D8 were area of the CL, luteal vascularity, number of colored pixels and total pixel intensity, and concentrations of plasma progesterone (P4). No effect (. P > .1) of dose or time of treatment was observed for any end point, within each day. Luteal area did not differ throughout the days (. P > .1), whereas Doppler parameters and concentrations of plasma P4 presented a progressive increase (. P < .05) after ovulation in all groups. Secretory function and luteal hemodynamic were not affected (. P > .1) by hCG dose and time of treatment. In conclusion, hCG therapy during estrus or early diestrus, at the doses tested, did not improve P4 secretion or luteal blood flow.Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESPSchool of Animal Sciences, Louisiana State University Agricultural CenterDepartment of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESPUniversidade Estadual Paulista (Unesp)School of Animal Sciences, Louisiana State University Agricultural CenterRomano, Rafael Mide [UNESP]Ferreira, Jair Camargo [UNESP]de Siqueira Canesin, Heloisa [UNESP]Boakari, Yatta Linhares [UNESP]Ignácio, Fernanda Saules [UNESP]Novaes Filho, Luiz Fernando [UNESP]Thompson, Donald L.de Meira, Cezinande [UNESP]2018-12-11T16:58:06Z2018-12-11T16:58:06Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article591-597application/pdfhttp://dx.doi.org/10.1016/j.jevs.2015.03.196Journal of Equine Veterinary Science, v. 35, n. 7, p. 591-597, 2015.0737-0806http://hdl.handle.net/11449/17200410.1016/j.jevs.2015.03.1962-s2.0-849395990352-s2.0-84939599035.pdf00429054157111990000-0002-2245-800XScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Equine Veterinary Science0,390info:eu-repo/semantics/openAccess2024-09-09T14:00:26Zoai:repositorio.unesp.br:11449/172004Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-09T14:00:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Characterization of Luteal Blood Flow and Secretion of Progesterone in Mares Treated With Human Chorionic Gonadotropin for Ovulation Induction or During Early Diestrus |
title |
Characterization of Luteal Blood Flow and Secretion of Progesterone in Mares Treated With Human Chorionic Gonadotropin for Ovulation Induction or During Early Diestrus |
spellingShingle |
Characterization of Luteal Blood Flow and Secretion of Progesterone in Mares Treated With Human Chorionic Gonadotropin for Ovulation Induction or During Early Diestrus Romano, Rafael Mide [UNESP] Blood flow Corpus luteum Diestrus Doppler ultrasonography Progesterone |
title_short |
Characterization of Luteal Blood Flow and Secretion of Progesterone in Mares Treated With Human Chorionic Gonadotropin for Ovulation Induction or During Early Diestrus |
title_full |
Characterization of Luteal Blood Flow and Secretion of Progesterone in Mares Treated With Human Chorionic Gonadotropin for Ovulation Induction or During Early Diestrus |
title_fullStr |
Characterization of Luteal Blood Flow and Secretion of Progesterone in Mares Treated With Human Chorionic Gonadotropin for Ovulation Induction or During Early Diestrus |
title_full_unstemmed |
Characterization of Luteal Blood Flow and Secretion of Progesterone in Mares Treated With Human Chorionic Gonadotropin for Ovulation Induction or During Early Diestrus |
title_sort |
Characterization of Luteal Blood Flow and Secretion of Progesterone in Mares Treated With Human Chorionic Gonadotropin for Ovulation Induction or During Early Diestrus |
author |
Romano, Rafael Mide [UNESP] |
author_facet |
Romano, Rafael Mide [UNESP] Ferreira, Jair Camargo [UNESP] de Siqueira Canesin, Heloisa [UNESP] Boakari, Yatta Linhares [UNESP] Ignácio, Fernanda Saules [UNESP] Novaes Filho, Luiz Fernando [UNESP] Thompson, Donald L. de Meira, Cezinande [UNESP] |
author_role |
author |
author2 |
Ferreira, Jair Camargo [UNESP] de Siqueira Canesin, Heloisa [UNESP] Boakari, Yatta Linhares [UNESP] Ignácio, Fernanda Saules [UNESP] Novaes Filho, Luiz Fernando [UNESP] Thompson, Donald L. de Meira, Cezinande [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) School of Animal Sciences, Louisiana State University Agricultural Center |
dc.contributor.author.fl_str_mv |
Romano, Rafael Mide [UNESP] Ferreira, Jair Camargo [UNESP] de Siqueira Canesin, Heloisa [UNESP] Boakari, Yatta Linhares [UNESP] Ignácio, Fernanda Saules [UNESP] Novaes Filho, Luiz Fernando [UNESP] Thompson, Donald L. de Meira, Cezinande [UNESP] |
dc.subject.por.fl_str_mv |
Blood flow Corpus luteum Diestrus Doppler ultrasonography Progesterone |
topic |
Blood flow Corpus luteum Diestrus Doppler ultrasonography Progesterone |
description |
Human chorionic gonadotropin (hCG) has been used to induce ovulation and as a luteotrophic agent in cattle. However, the effect of hCG therapy on the functional status of the equine corpus luteum (CL) is unclear. This study aimed to characterize the hemodynamic and secretory function of early CL of mares treated with different doses of hCG at distinct stages of the estrous cycle. Mares were assigned to nine experimental groups (n = 6 mares/group) according to dose of hCG and time of treatment. A single injection of one of three different doses of hCG (750, 1,500, or 2,500 IU) was performed in one of three distinct stages of the estrous cycle: preovulatory follicle ≥35mm, day of ovulation (D0), or 48hours after ovulation (D2). In addition, a control group treated with NaCl 0.9% was included in the study. The end points evaluated daily from D0 to D8 were area of the CL, luteal vascularity, number of colored pixels and total pixel intensity, and concentrations of plasma progesterone (P4). No effect (. P > .1) of dose or time of treatment was observed for any end point, within each day. Luteal area did not differ throughout the days (. P > .1), whereas Doppler parameters and concentrations of plasma P4 presented a progressive increase (. P < .05) after ovulation in all groups. Secretory function and luteal hemodynamic were not affected (. P > .1) by hCG dose and time of treatment. In conclusion, hCG therapy during estrus or early diestrus, at the doses tested, did not improve P4 secretion or luteal blood flow. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 2018-12-11T16:58:06Z 2018-12-11T16:58:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jevs.2015.03.196 Journal of Equine Veterinary Science, v. 35, n. 7, p. 591-597, 2015. 0737-0806 http://hdl.handle.net/11449/172004 10.1016/j.jevs.2015.03.196 2-s2.0-84939599035 2-s2.0-84939599035.pdf 0042905415711199 0000-0002-2245-800X |
url |
http://dx.doi.org/10.1016/j.jevs.2015.03.196 http://hdl.handle.net/11449/172004 |
identifier_str_mv |
Journal of Equine Veterinary Science, v. 35, n. 7, p. 591-597, 2015. 0737-0806 10.1016/j.jevs.2015.03.196 2-s2.0-84939599035 2-s2.0-84939599035.pdf 0042905415711199 0000-0002-2245-800X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Equine Veterinary Science 0,390 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
591-597 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546544356392960 |