Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital

Detalhes bibliográficos
Autor(a) principal: Varallo, Fabiana Rossi
Data de Publicação: 2014
Outros Autores: Capucho, Helaine Carneiro, Da Silva Planeta, Cleopatra, De Carvalho Mastroianni, Patricia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.6061/clinics/2014(03)03
http://hdl.handle.net/11449/110223
Resumo: OBJECTIVES: Drug safety problems can lead to hospital admission. In Brazil, the prevalence of hospitalization due to adverse drug events is unknown. This study aims to estimate the prevalence of hospitalization due to adverse drug events and to identify the drugs, the adverse drug events, and the risk factors associated with hospital admissions. METHOD: A cross-sectional study was performed in the internal medicine ward of a teaching hospital in São Paulo State, Brazil, from August to December 2008. All patients aged ≥18 years with a length of stay ≥24 hours were interviewed about the drugs used prior to hospital admission and their symptoms/complaints/causes of hospitalization. RESULTS: In total, 248 patients were considered eligible. The prevalence of hospitalization due to potential adverse drug events in the ward was 46.4%. Overprescribed drugs and those indicated for prophylactic treatments were frequently associated with possible adverse drug events. Frequently reported symptoms were breathlessness (15.2%), fatigue (12.3%), and chest pain (9.0%). Polypharmacy was a risk factor for the occurrence of possible adverse drug events. CONCLUSION: Possible adverse drug events led to hospitalization in a high-complexity hospital, mainly in polymedicated patients. The clinical outcomes of adverse drug events are nonspecific, which delays treatment, hinders causality analysis, and contributes to the underreporting of cases.
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spelling Possible adverse drug events leading to hospital admission in a Brazilian teaching hospitalAdverse Drug Reaction Reporting SystemsProduct SurveillancePostmarketingPharmacovigilanceAdmitting DepartmentHospitalOBJECTIVES: Drug safety problems can lead to hospital admission. In Brazil, the prevalence of hospitalization due to adverse drug events is unknown. This study aims to estimate the prevalence of hospitalization due to adverse drug events and to identify the drugs, the adverse drug events, and the risk factors associated with hospital admissions. METHOD: A cross-sectional study was performed in the internal medicine ward of a teaching hospital in São Paulo State, Brazil, from August to December 2008. All patients aged ≥18 years with a length of stay ≥24 hours were interviewed about the drugs used prior to hospital admission and their symptoms/complaints/causes of hospitalization. RESULTS: In total, 248 patients were considered eligible. The prevalence of hospitalization due to potential adverse drug events in the ward was 46.4%. Overprescribed drugs and those indicated for prophylactic treatments were frequently associated with possible adverse drug events. Frequently reported symptoms were breathlessness (15.2%), fatigue (12.3%), and chest pain (9.0%). Polypharmacy was a risk factor for the occurrence of possible adverse drug events. CONCLUSION: Possible adverse drug events led to hospitalization in a high-complexity hospital, mainly in polymedicated patients. The clinical outcomes of adverse drug events are nonspecific, which delays treatment, hinders causality analysis, and contributes to the underreporting of cases.Universidade Estadual Paulista Julio de Mesquita Filho School of Pharmaceutical Sciences Department of Drugs and MedicationsMinisterio da Saude Comissao Nacional de Incorporacao de TecnologiasUniversidade Estadual Paulista Julio de Mesquita Filho School of Pharmaceutical Sciences Department of Natural Active Principles and ToxicologyUniversidade Estadual Paulista Julio de Mesquita Filho School of Pharmaceutical Sciences Department of Drugs and MedicationsUniversidade Estadual Paulista Julio de Mesquita Filho School of Pharmaceutical Sciences Department of Natural Active Principles and ToxicologyUniversidade de São Paulo (USP), Faculdade de MedicinaUniversidade Estadual Paulista (Unesp)Ministerio da Saude Comissao Nacional de Incorporacao de TecnologiasVarallo, Fabiana RossiCapucho, Helaine CarneiroDa Silva Planeta, CleopatraDe Carvalho Mastroianni, Patricia2014-10-01T13:08:56Z2014-10-01T13:08:56Z2014-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article163-167application/pdfhttp://dx.doi.org/10.6061/clinics/2014(03)03Clinics. Faculdade de Medicina / USP, v. 69, n. 3, p. 163-167, 2014.1807-5932http://hdl.handle.net/11449/11022310.6061/clinics/2014(03)03S1807-59322014000300163WOS:000333034000003S1807-59322014000300163.pdf25147625452809420000-0002-1378-6327SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinics1.2450,536info:eu-repo/semantics/openAccess2024-06-24T14:51:22Zoai:repositorio.unesp.br:11449/110223Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:42:05.862795Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital
title Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital
spellingShingle Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital
Varallo, Fabiana Rossi
Adverse Drug Reaction Reporting Systems
Product Surveillance
Postmarketing
Pharmacovigilance
Admitting Department
Hospital
title_short Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital
title_full Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital
title_fullStr Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital
title_full_unstemmed Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital
title_sort Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital
author Varallo, Fabiana Rossi
author_facet Varallo, Fabiana Rossi
Capucho, Helaine Carneiro
Da Silva Planeta, Cleopatra
De Carvalho Mastroianni, Patricia
author_role author
author2 Capucho, Helaine Carneiro
Da Silva Planeta, Cleopatra
De Carvalho Mastroianni, Patricia
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Ministerio da Saude Comissao Nacional de Incorporacao de Tecnologias
dc.contributor.author.fl_str_mv Varallo, Fabiana Rossi
Capucho, Helaine Carneiro
Da Silva Planeta, Cleopatra
De Carvalho Mastroianni, Patricia
dc.subject.por.fl_str_mv Adverse Drug Reaction Reporting Systems
Product Surveillance
Postmarketing
Pharmacovigilance
Admitting Department
Hospital
topic Adverse Drug Reaction Reporting Systems
Product Surveillance
Postmarketing
Pharmacovigilance
Admitting Department
Hospital
description OBJECTIVES: Drug safety problems can lead to hospital admission. In Brazil, the prevalence of hospitalization due to adverse drug events is unknown. This study aims to estimate the prevalence of hospitalization due to adverse drug events and to identify the drugs, the adverse drug events, and the risk factors associated with hospital admissions. METHOD: A cross-sectional study was performed in the internal medicine ward of a teaching hospital in São Paulo State, Brazil, from August to December 2008. All patients aged ≥18 years with a length of stay ≥24 hours were interviewed about the drugs used prior to hospital admission and their symptoms/complaints/causes of hospitalization. RESULTS: In total, 248 patients were considered eligible. The prevalence of hospitalization due to potential adverse drug events in the ward was 46.4%. Overprescribed drugs and those indicated for prophylactic treatments were frequently associated with possible adverse drug events. Frequently reported symptoms were breathlessness (15.2%), fatigue (12.3%), and chest pain (9.0%). Polypharmacy was a risk factor for the occurrence of possible adverse drug events. CONCLUSION: Possible adverse drug events led to hospitalization in a high-complexity hospital, mainly in polymedicated patients. The clinical outcomes of adverse drug events are nonspecific, which delays treatment, hinders causality analysis, and contributes to the underreporting of cases.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-01T13:08:56Z
2014-10-01T13:08:56Z
2014-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.6061/clinics/2014(03)03
Clinics. Faculdade de Medicina / USP, v. 69, n. 3, p. 163-167, 2014.
1807-5932
http://hdl.handle.net/11449/110223
10.6061/clinics/2014(03)03
S1807-59322014000300163
WOS:000333034000003
S1807-59322014000300163.pdf
2514762545280942
0000-0002-1378-6327
url http://dx.doi.org/10.6061/clinics/2014(03)03
http://hdl.handle.net/11449/110223
identifier_str_mv Clinics. Faculdade de Medicina / USP, v. 69, n. 3, p. 163-167, 2014.
1807-5932
10.6061/clinics/2014(03)03
S1807-59322014000300163
WOS:000333034000003
S1807-59322014000300163.pdf
2514762545280942
0000-0002-1378-6327
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinics
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 163-167
application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo (USP), Faculdade de Medicina
publisher.none.fl_str_mv Universidade de São Paulo (USP), Faculdade de Medicina
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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