Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.6061/clinics/2014(03)03 http://hdl.handle.net/11449/110223 |
Resumo: | OBJECTIVES: Drug safety problems can lead to hospital admission. In Brazil, the prevalence of hospitalization due to adverse drug events is unknown. This study aims to estimate the prevalence of hospitalization due to adverse drug events and to identify the drugs, the adverse drug events, and the risk factors associated with hospital admissions. METHOD: A cross-sectional study was performed in the internal medicine ward of a teaching hospital in São Paulo State, Brazil, from August to December 2008. All patients aged ≥18 years with a length of stay ≥24 hours were interviewed about the drugs used prior to hospital admission and their symptoms/complaints/causes of hospitalization. RESULTS: In total, 248 patients were considered eligible. The prevalence of hospitalization due to potential adverse drug events in the ward was 46.4%. Overprescribed drugs and those indicated for prophylactic treatments were frequently associated with possible adverse drug events. Frequently reported symptoms were breathlessness (15.2%), fatigue (12.3%), and chest pain (9.0%). Polypharmacy was a risk factor for the occurrence of possible adverse drug events. CONCLUSION: Possible adverse drug events led to hospitalization in a high-complexity hospital, mainly in polymedicated patients. The clinical outcomes of adverse drug events are nonspecific, which delays treatment, hinders causality analysis, and contributes to the underreporting of cases. |
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Possible adverse drug events leading to hospital admission in a Brazilian teaching hospitalAdverse Drug Reaction Reporting SystemsProduct SurveillancePostmarketingPharmacovigilanceAdmitting DepartmentHospitalOBJECTIVES: Drug safety problems can lead to hospital admission. In Brazil, the prevalence of hospitalization due to adverse drug events is unknown. This study aims to estimate the prevalence of hospitalization due to adverse drug events and to identify the drugs, the adverse drug events, and the risk factors associated with hospital admissions. METHOD: A cross-sectional study was performed in the internal medicine ward of a teaching hospital in São Paulo State, Brazil, from August to December 2008. All patients aged ≥18 years with a length of stay ≥24 hours were interviewed about the drugs used prior to hospital admission and their symptoms/complaints/causes of hospitalization. RESULTS: In total, 248 patients were considered eligible. The prevalence of hospitalization due to potential adverse drug events in the ward was 46.4%. Overprescribed drugs and those indicated for prophylactic treatments were frequently associated with possible adverse drug events. Frequently reported symptoms were breathlessness (15.2%), fatigue (12.3%), and chest pain (9.0%). Polypharmacy was a risk factor for the occurrence of possible adverse drug events. CONCLUSION: Possible adverse drug events led to hospitalization in a high-complexity hospital, mainly in polymedicated patients. The clinical outcomes of adverse drug events are nonspecific, which delays treatment, hinders causality analysis, and contributes to the underreporting of cases.Universidade Estadual Paulista Julio de Mesquita Filho School of Pharmaceutical Sciences Department of Drugs and MedicationsMinisterio da Saude Comissao Nacional de Incorporacao de TecnologiasUniversidade Estadual Paulista Julio de Mesquita Filho School of Pharmaceutical Sciences Department of Natural Active Principles and ToxicologyUniversidade Estadual Paulista Julio de Mesquita Filho School of Pharmaceutical Sciences Department of Drugs and MedicationsUniversidade Estadual Paulista Julio de Mesquita Filho School of Pharmaceutical Sciences Department of Natural Active Principles and ToxicologyUniversidade de São Paulo (USP), Faculdade de MedicinaUniversidade Estadual Paulista (Unesp)Ministerio da Saude Comissao Nacional de Incorporacao de TecnologiasVarallo, Fabiana RossiCapucho, Helaine CarneiroDa Silva Planeta, CleopatraDe Carvalho Mastroianni, Patricia2014-10-01T13:08:56Z2014-10-01T13:08:56Z2014-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article163-167application/pdfhttp://dx.doi.org/10.6061/clinics/2014(03)03Clinics. Faculdade de Medicina / USP, v. 69, n. 3, p. 163-167, 2014.1807-5932http://hdl.handle.net/11449/11022310.6061/clinics/2014(03)03S1807-59322014000300163WOS:000333034000003S1807-59322014000300163.pdf25147625452809420000-0002-1378-6327SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinics1.2450,536info:eu-repo/semantics/openAccess2024-06-24T14:51:22Zoai:repositorio.unesp.br:11449/110223Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:42:05.862795Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital |
title |
Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital |
spellingShingle |
Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital Varallo, Fabiana Rossi Adverse Drug Reaction Reporting Systems Product Surveillance Postmarketing Pharmacovigilance Admitting Department Hospital |
title_short |
Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital |
title_full |
Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital |
title_fullStr |
Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital |
title_full_unstemmed |
Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital |
title_sort |
Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital |
author |
Varallo, Fabiana Rossi |
author_facet |
Varallo, Fabiana Rossi Capucho, Helaine Carneiro Da Silva Planeta, Cleopatra De Carvalho Mastroianni, Patricia |
author_role |
author |
author2 |
Capucho, Helaine Carneiro Da Silva Planeta, Cleopatra De Carvalho Mastroianni, Patricia |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Ministerio da Saude Comissao Nacional de Incorporacao de Tecnologias |
dc.contributor.author.fl_str_mv |
Varallo, Fabiana Rossi Capucho, Helaine Carneiro Da Silva Planeta, Cleopatra De Carvalho Mastroianni, Patricia |
dc.subject.por.fl_str_mv |
Adverse Drug Reaction Reporting Systems Product Surveillance Postmarketing Pharmacovigilance Admitting Department Hospital |
topic |
Adverse Drug Reaction Reporting Systems Product Surveillance Postmarketing Pharmacovigilance Admitting Department Hospital |
description |
OBJECTIVES: Drug safety problems can lead to hospital admission. In Brazil, the prevalence of hospitalization due to adverse drug events is unknown. This study aims to estimate the prevalence of hospitalization due to adverse drug events and to identify the drugs, the adverse drug events, and the risk factors associated with hospital admissions. METHOD: A cross-sectional study was performed in the internal medicine ward of a teaching hospital in São Paulo State, Brazil, from August to December 2008. All patients aged ≥18 years with a length of stay ≥24 hours were interviewed about the drugs used prior to hospital admission and their symptoms/complaints/causes of hospitalization. RESULTS: In total, 248 patients were considered eligible. The prevalence of hospitalization due to potential adverse drug events in the ward was 46.4%. Overprescribed drugs and those indicated for prophylactic treatments were frequently associated with possible adverse drug events. Frequently reported symptoms were breathlessness (15.2%), fatigue (12.3%), and chest pain (9.0%). Polypharmacy was a risk factor for the occurrence of possible adverse drug events. CONCLUSION: Possible adverse drug events led to hospitalization in a high-complexity hospital, mainly in polymedicated patients. The clinical outcomes of adverse drug events are nonspecific, which delays treatment, hinders causality analysis, and contributes to the underreporting of cases. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10-01T13:08:56Z 2014-10-01T13:08:56Z 2014-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.6061/clinics/2014(03)03 Clinics. Faculdade de Medicina / USP, v. 69, n. 3, p. 163-167, 2014. 1807-5932 http://hdl.handle.net/11449/110223 10.6061/clinics/2014(03)03 S1807-59322014000300163 WOS:000333034000003 S1807-59322014000300163.pdf 2514762545280942 0000-0002-1378-6327 |
url |
http://dx.doi.org/10.6061/clinics/2014(03)03 http://hdl.handle.net/11449/110223 |
identifier_str_mv |
Clinics. Faculdade de Medicina / USP, v. 69, n. 3, p. 163-167, 2014. 1807-5932 10.6061/clinics/2014(03)03 S1807-59322014000300163 WOS:000333034000003 S1807-59322014000300163.pdf 2514762545280942 0000-0002-1378-6327 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinics 1.245 0,536 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
163-167 application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo (USP), Faculdade de Medicina |
publisher.none.fl_str_mv |
Universidade de São Paulo (USP), Faculdade de Medicina |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128267911168000 |