Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.foodchem.2011.10.110 http://hdl.handle.net/11449/42633 |
Resumo: | A new glycosylated biflavonone, morelloflavone-4 '''-O-beta-D-glycosyl, and the known compounds 1,3,6,7-tetrahydroxyxanthone, morelloflavone (fukugetin) and morelloflavone-7 ''-O-beta-D-glycosyl (fukugeside) were isolated from the epicarp of Garcinia brasiliensis collected in Brazil. The structures of these compounds were established using H-1 and C-13 NMR, COSY, gHMQC and gHMBC spectroscopy. The compounds exhibited antioxidant activity. The greatest potency was displayed by morelloflavone (2), with IC50 = 49.5 mM against DPPH and absorbance of 0.583 at 400 mu g/mL for the reduction of Fe3+. The weakest potency was displayed by 1,3,6,7-tetrahydroxyxanthone (1), with IC50 = 148 mM against DPPH and absorbance of 0.194 at 400 mu g/mL for the reduction of Fe3+. (C) 2011 Elsevier Ltd. All rights reserved. |
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Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarpGarcinia brasiliensisBiflavonoidsNatural productsAntioxidantsA new glycosylated biflavonone, morelloflavone-4 '''-O-beta-D-glycosyl, and the known compounds 1,3,6,7-tetrahydroxyxanthone, morelloflavone (fukugetin) and morelloflavone-7 ''-O-beta-D-glycosyl (fukugeside) were isolated from the epicarp of Garcinia brasiliensis collected in Brazil. The structures of these compounds were established using H-1 and C-13 NMR, COSY, gHMQC and gHMBC spectroscopy. The compounds exhibited antioxidant activity. The greatest potency was displayed by morelloflavone (2), with IC50 = 49.5 mM against DPPH and absorbance of 0.583 at 400 mu g/mL for the reduction of Fe3+. The weakest potency was displayed by 1,3,6,7-tetrahydroxyxanthone (1), with IC50 = 148 mM against DPPH and absorbance of 0.194 at 400 mu g/mL for the reduction of Fe3+. (C) 2011 Elsevier Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Financiadora de Estudos e Projetos (FINEP)Univ Fed Alfenas, Lab Fitoquim & Quim Med, Inst Quim Exatas, UNIFAL MG, Alfenas, MG, BrazilUniv Fed Alfenas, Lab Plantas Med & Fitoterapicos, Fac Ciencias Farmaceut, UNIFAL MG, Alfenas, MG, BrazilUNESP, Dept Quim Organ, Inst Quim Araraquara, Araraquara, BrazilUNESP, Dept Quim Organ, Inst Quim Araraquara, Araraquara, BrazilElsevier B.V.Universidade Federal de Alfenas (UNIFAL)Universidade Estadual Paulista (Unesp)Gontijo, Vanessa Silvade Souza, Thiago CorreaRosa, Isael AparecidoSoares, Marisi Gomesda Silva, Marcelo AparecidoVilegas, Wagner [UNESP]Viegas Junior, Claudiodos Santos, Marcelo Henrique2014-05-20T15:34:43Z2014-05-20T15:34:43Z2012-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1230-1235application/pdfhttp://dx.doi.org/10.1016/j.foodchem.2011.10.110Food Chemistry. Oxford: Elsevier B.V., v. 132, n. 3, p. 1230-1235, 2012.0308-8146http://hdl.handle.net/11449/4263310.1016/j.foodchem.2011.10.110WOS:000301022400016WOS000301022400016.pdf0000-0003-3032-2556Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood Chemistry4.9461,793info:eu-repo/semantics/openAccess2024-01-06T06:23:49Zoai:repositorio.unesp.br:11449/42633Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:14:15.321770Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp |
title |
Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp |
spellingShingle |
Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp Gontijo, Vanessa Silva Garcinia brasiliensis Biflavonoids Natural products Antioxidants |
title_short |
Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp |
title_full |
Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp |
title_fullStr |
Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp |
title_full_unstemmed |
Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp |
title_sort |
Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp |
author |
Gontijo, Vanessa Silva |
author_facet |
Gontijo, Vanessa Silva de Souza, Thiago Correa Rosa, Isael Aparecido Soares, Marisi Gomes da Silva, Marcelo Aparecido Vilegas, Wagner [UNESP] Viegas Junior, Claudio dos Santos, Marcelo Henrique |
author_role |
author |
author2 |
de Souza, Thiago Correa Rosa, Isael Aparecido Soares, Marisi Gomes da Silva, Marcelo Aparecido Vilegas, Wagner [UNESP] Viegas Junior, Claudio dos Santos, Marcelo Henrique |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Alfenas (UNIFAL) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Gontijo, Vanessa Silva de Souza, Thiago Correa Rosa, Isael Aparecido Soares, Marisi Gomes da Silva, Marcelo Aparecido Vilegas, Wagner [UNESP] Viegas Junior, Claudio dos Santos, Marcelo Henrique |
dc.subject.por.fl_str_mv |
Garcinia brasiliensis Biflavonoids Natural products Antioxidants |
topic |
Garcinia brasiliensis Biflavonoids Natural products Antioxidants |
description |
A new glycosylated biflavonone, morelloflavone-4 '''-O-beta-D-glycosyl, and the known compounds 1,3,6,7-tetrahydroxyxanthone, morelloflavone (fukugetin) and morelloflavone-7 ''-O-beta-D-glycosyl (fukugeside) were isolated from the epicarp of Garcinia brasiliensis collected in Brazil. The structures of these compounds were established using H-1 and C-13 NMR, COSY, gHMQC and gHMBC spectroscopy. The compounds exhibited antioxidant activity. The greatest potency was displayed by morelloflavone (2), with IC50 = 49.5 mM against DPPH and absorbance of 0.583 at 400 mu g/mL for the reduction of Fe3+. The weakest potency was displayed by 1,3,6,7-tetrahydroxyxanthone (1), with IC50 = 148 mM against DPPH and absorbance of 0.194 at 400 mu g/mL for the reduction of Fe3+. (C) 2011 Elsevier Ltd. All rights reserved. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-01 2014-05-20T15:34:43Z 2014-05-20T15:34:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.foodchem.2011.10.110 Food Chemistry. Oxford: Elsevier B.V., v. 132, n. 3, p. 1230-1235, 2012. 0308-8146 http://hdl.handle.net/11449/42633 10.1016/j.foodchem.2011.10.110 WOS:000301022400016 WOS000301022400016.pdf 0000-0003-3032-2556 |
url |
http://dx.doi.org/10.1016/j.foodchem.2011.10.110 http://hdl.handle.net/11449/42633 |
identifier_str_mv |
Food Chemistry. Oxford: Elsevier B.V., v. 132, n. 3, p. 1230-1235, 2012. 0308-8146 10.1016/j.foodchem.2011.10.110 WOS:000301022400016 WOS000301022400016.pdf 0000-0003-3032-2556 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Food Chemistry 4.946 1,793 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1230-1235 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129407354667008 |