Titanium-Based Alloy Surface Modification with TiO2and Poly(sodium 4-styrenesulfonate) Multilayers for Dental Implants

• Autor(a) principal: Kitagawa, Igor L. [UNESP]
• Data de Publicação: 2021
• Outros Autores: Miyazaki, Celina M., Pitol-Palin, Letícia [UNESP], Okamoto, Roberta [UNESP], De Vasconcellos, Luana M. R. [UNESP], Constantino, Carlos J. L. [UNESP], Lisboa-Filho, Paulo N. [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1021/acsabm.0c01348; http://hdl.handle.net/11449/207548
• topic: dental implant; in vivo tests; layer-by-layer; PSS; TiO2

Implant placement is an important repair method in dentistry and orthopedics. Increasing efforts have focused on optimizing the biocompatibility and osseointegration properties of titanium (Ti) and Ti-based alloys. In this work, Ti-based alloys were modified by the layer-by-layer (LbL) technique, which is a simple and versatile method for surface modification. The morphology and chemical structure of LbL films of poly(sodium 4-styrenesulfonate) (PSS) and Ti dioxide (TiO2) nanoparticles were first characterized employing ultraviolet-visible and Fourier-transform infrared spectroscopies as well as atomic force microscopy for further application in Ti-based alloy implants. The changes provoked by the LbL PSS/TiO2 film on the Ti-based alloy surfaces were then investigated by scanning electron microscopy and micro-Raman techniques. Finally, in vivo tests (immunolabeling and biomechanical analysis) performed with screw implants in rats suggested that PSS/TiO2 multilayers promote changes in both topography and chemical surface properties of the screw, providing beneficial effects for osteoblast activity. This simple and relatively low-cost growth process can open up possibilities to improve dental implants and, probably, bone implants in general.