Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2017/6067172 http://hdl.handle.net/11449/159573 |
Resumo: | Treatments based on antimonials to cutaneous leishmaniasis (CL) entail a range of toxic side effects. Propolis, a natural compound widely used in traditional medical applications, exhibits a range of biological effects, including activity against infectious agents. The aim of this study was to test the potential leishmanicidal effects of different propolis extracts against Leishmania (Viannia) braziliensis promastigotes and intracellular amastigotes in vitro. Stationary-phase L. (V) braziliensis promastigotes were incubated with mediumalone or treated with dry, alcoholic, or glycolic propolis extract (10, 50, or 100 mu g/mL) for 96 h. Our data showed that all extracts exhibited a dose-dependent effect on the viability of L. (V) braziliensis promastigotes, while controlling the parasite burden inside infected macrophages. Dry propolis extract significantly modified the inflammatory profile of murine macrophages by downmodulating TGF-beta and IL-10 production, while upmodulating TNF-alpha All three types of propolis extractwere found to reduce nitric oxide and superoxide levels in activated L. braziliensis-infected macrophages. Altogether, our results showed that propolis extracts exhibited a leishmanicidal effect against both stages of L. (V) braziliensis. The low cell toxicity and efficient microbicidal effect of alcoholic or glycolic propolis extracts make them candidates to an additive treatment for cutaneous leishmaniasis. |
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Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis ExtractsTreatments based on antimonials to cutaneous leishmaniasis (CL) entail a range of toxic side effects. Propolis, a natural compound widely used in traditional medical applications, exhibits a range of biological effects, including activity against infectious agents. The aim of this study was to test the potential leishmanicidal effects of different propolis extracts against Leishmania (Viannia) braziliensis promastigotes and intracellular amastigotes in vitro. Stationary-phase L. (V) braziliensis promastigotes were incubated with mediumalone or treated with dry, alcoholic, or glycolic propolis extract (10, 50, or 100 mu g/mL) for 96 h. Our data showed that all extracts exhibited a dose-dependent effect on the viability of L. (V) braziliensis promastigotes, while controlling the parasite burden inside infected macrophages. Dry propolis extract significantly modified the inflammatory profile of murine macrophages by downmodulating TGF-beta and IL-10 production, while upmodulating TNF-alpha All three types of propolis extractwere found to reduce nitric oxide and superoxide levels in activated L. braziliensis-infected macrophages. Altogether, our results showed that propolis extracts exhibited a leishmanicidal effect against both stages of L. (V) braziliensis. The low cell toxicity and efficient microbicidal effect of alcoholic or glycolic propolis extracts make them candidates to an additive treatment for cutaneous leishmaniasis.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Financiadora de Estudos e Projetos, FINEPCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundacao Oswaldo Cruz, Inst Goncalo Moniz, Salvador, BA, BrazilUniv Fed Bahia, Salvador, BA, BrazilUniv Fed Oeste Bahia, Ctr Ciencias Biol & Saude, Barreiras, BA, BrazilUniv Estadual Paulista, Inst Quim, Araraquara, SP, BrazilUniv Araraquara, Programa Posgrad Biotecnol, Araraquara, SP, BrazilApis Flora Ind & Comercial Ltda, Lab Pesquisa Desenvolvimento & Inovacao, Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, Ave Cafe S-N, BR-14049900 Ribeirao Preto, SP, BrazilUniv Estadual Paulista, Inst Quim, Araraquara, SP, BrazilCNPq: 309988/2014-4FAPESP: 2013/50496-2Financiadora de Estudos e Projetos, FINEP: 03.12.0056.00Hindawi LtdFundacao Oswaldo CruzUniversidade Federal da Bahia (UFBA)Univ Fed Oeste BahiaUniversidade Estadual Paulista (Unesp)Univ AraraquaraApis Flora Ind & Comercial LtdaUniversidade de São Paulo (USP)Reboucas-Silva, JessicaCeles, Fabiana S.Lima, Jonilson BerlinkBarud, Hernane S. [UNESP]Oliveira, Camila I. deBerretta, Andresa A.Borges, Valeria M.2018-11-26T15:44:20Z2018-11-26T15:44:20Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://dx.doi.org/10.1155/2017/6067172Evidence-based Complementary And Alternative Medicine. London: Hindawi Ltd, 14 p., 2017.1741-427Xhttp://hdl.handle.net/11449/15957310.1155/2017/6067172WOS:000403240600001WOS000403240600001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvidence-based Complementary And Alternative Medicineinfo:eu-repo/semantics/openAccess2024-01-13T06:36:25Zoai:repositorio.unesp.br:11449/159573Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-13T06:36:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
title |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
spellingShingle |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts Reboucas-Silva, Jessica |
title_short |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
title_full |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
title_fullStr |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
title_full_unstemmed |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
title_sort |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
author |
Reboucas-Silva, Jessica |
author_facet |
Reboucas-Silva, Jessica Celes, Fabiana S. Lima, Jonilson Berlink Barud, Hernane S. [UNESP] Oliveira, Camila I. de Berretta, Andresa A. Borges, Valeria M. |
author_role |
author |
author2 |
Celes, Fabiana S. Lima, Jonilson Berlink Barud, Hernane S. [UNESP] Oliveira, Camila I. de Berretta, Andresa A. Borges, Valeria M. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Fundacao Oswaldo Cruz Universidade Federal da Bahia (UFBA) Univ Fed Oeste Bahia Universidade Estadual Paulista (Unesp) Univ Araraquara Apis Flora Ind & Comercial Ltda Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Reboucas-Silva, Jessica Celes, Fabiana S. Lima, Jonilson Berlink Barud, Hernane S. [UNESP] Oliveira, Camila I. de Berretta, Andresa A. Borges, Valeria M. |
description |
Treatments based on antimonials to cutaneous leishmaniasis (CL) entail a range of toxic side effects. Propolis, a natural compound widely used in traditional medical applications, exhibits a range of biological effects, including activity against infectious agents. The aim of this study was to test the potential leishmanicidal effects of different propolis extracts against Leishmania (Viannia) braziliensis promastigotes and intracellular amastigotes in vitro. Stationary-phase L. (V) braziliensis promastigotes were incubated with mediumalone or treated with dry, alcoholic, or glycolic propolis extract (10, 50, or 100 mu g/mL) for 96 h. Our data showed that all extracts exhibited a dose-dependent effect on the viability of L. (V) braziliensis promastigotes, while controlling the parasite burden inside infected macrophages. Dry propolis extract significantly modified the inflammatory profile of murine macrophages by downmodulating TGF-beta and IL-10 production, while upmodulating TNF-alpha All three types of propolis extractwere found to reduce nitric oxide and superoxide levels in activated L. braziliensis-infected macrophages. Altogether, our results showed that propolis extracts exhibited a leishmanicidal effect against both stages of L. (V) braziliensis. The low cell toxicity and efficient microbicidal effect of alcoholic or glycolic propolis extracts make them candidates to an additive treatment for cutaneous leishmaniasis. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-11-26T15:44:20Z 2018-11-26T15:44:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2017/6067172 Evidence-based Complementary And Alternative Medicine. London: Hindawi Ltd, 14 p., 2017. 1741-427X http://hdl.handle.net/11449/159573 10.1155/2017/6067172 WOS:000403240600001 WOS000403240600001.pdf |
url |
http://dx.doi.org/10.1155/2017/6067172 http://hdl.handle.net/11449/159573 |
identifier_str_mv |
Evidence-based Complementary And Alternative Medicine. London: Hindawi Ltd, 14 p., 2017. 1741-427X 10.1155/2017/6067172 WOS:000403240600001 WOS000403240600001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Evidence-based Complementary And Alternative Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
14 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Ltd |
publisher.none.fl_str_mv |
Hindawi Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1803046691191914496 |