Potential of microalga Isochrysis galbana: Bioactivity and bioaccessibility
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.algal.2017.11.035 http://hdl.handle.net/11449/170437 |
Resumo: | The lipid composition and anti-inflammatory activity of the microalga Isochrysis galbana were studied. Moreover, the influence of bioaccessibility on composition and bioactivity was evaluated through the application of an in vitro model of the human digestion. The fatty acid (FA) profile was characterized by abundance of polyunsaturated FA (PUFA) and, within PUFA, ω3 PUFA were the most abundant. High contents of myristic, oleic, linoleic, α-linolenic, and stearidonic acids as well as docosahexaenoic acid (DHA) were determined. A low level of hydrolysis of triacylglycerols (TAGs) and polar lipids was observed during digestion. Total lipid bioaccessibility and specific FA bioaccessibility were low (between 7 and 15%). The highest bioaccessibility percentages were determined for palmitic, oleic, and linoleic acids as well as total ω6 PUFA and the lowest bioaccessible percentages were calculated for myristic and stearidonic acids, DHA, and total ω3 PUFA. Chemical affinity phenomena could be an explanation for these results. Regarding anti-inflammatory activity, it was only detected in the lipid extract of I. galbana prior to digestion (79 ± 7% of cyclooxygenase-2, COX-2, inhibition). No activity was found in the bioaccessible fraction extract. Apparently, the COX-2 inhibitory compounds were not rendered bioaccessible. |
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Potential of microalga Isochrysis galbana: Bioactivity and bioaccessibilityAnti-inflammatory activityBioaccessibilityIsochrysis galbanaLipid compositionω3 PUFAThe lipid composition and anti-inflammatory activity of the microalga Isochrysis galbana were studied. Moreover, the influence of bioaccessibility on composition and bioactivity was evaluated through the application of an in vitro model of the human digestion. The fatty acid (FA) profile was characterized by abundance of polyunsaturated FA (PUFA) and, within PUFA, ω3 PUFA were the most abundant. High contents of myristic, oleic, linoleic, α-linolenic, and stearidonic acids as well as docosahexaenoic acid (DHA) were determined. A low level of hydrolysis of triacylglycerols (TAGs) and polar lipids was observed during digestion. Total lipid bioaccessibility and specific FA bioaccessibility were low (between 7 and 15%). The highest bioaccessibility percentages were determined for palmitic, oleic, and linoleic acids as well as total ω6 PUFA and the lowest bioaccessible percentages were calculated for myristic and stearidonic acids, DHA, and total ω3 PUFA. Chemical affinity phenomena could be an explanation for these results. Regarding anti-inflammatory activity, it was only detected in the lipid extract of I. galbana prior to digestion (79 ± 7% of cyclooxygenase-2, COX-2, inhibition). No activity was found in the bioaccessible fraction extract. Apparently, the COX-2 inhibitory compounds were not rendered bioaccessible.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundació Catalana de TrasplantamentFundação para a Ciência e a TecnologiaBotucatu Medical School UNESP - Universidade Estadual Paulista, Botucatu CampusDivision of Aquaculture and Upgrading (DivAV) Portuguese Institute for the Sea and Atmosphere (IPMA IP), Rua Alfredo Magalhães Ramalho, 6CIIMAR Interdisciplinary Centre of Marine and Environmental Research University of Porto, Rua dos Bragas 289Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 16Botucatu Medical School UNESP - Universidade Estadual Paulista, Botucatu CampusCAPES: 88881.134961/2016-01Fundació Catalana de Trasplantament: SFRH/BD/129795/2017Fundação para a Ciência e a Tecnologia: SFRH/BPD/102689/2014Fundação para a Ciência e a Tecnologia: SFRH/BPD/64951/2009Universidade Estadual Paulista (Unesp)IP)University of PortoFaculdade de Ciências da Universidade de LisboaBonfanti, C. [UNESP]Cardoso, C.Afonso, C.Matos, J.Garcia, T. [UNESP]Tanni, S. [UNESP]Bandarra, N. M.2018-12-11T16:50:48Z2018-12-11T16:50:48Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article242-248application/pdfhttp://dx.doi.org/10.1016/j.algal.2017.11.035Algal Research, v. 29, p. 242-248.2211-9264http://hdl.handle.net/11449/17043710.1016/j.algal.2017.11.0352-s2.0-850364949852-s2.0-85036494985.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAlgal Research1,142info:eu-repo/semantics/openAccess2023-11-02T06:12:53Zoai:repositorio.unesp.br:11449/170437Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:45:16.697427Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Potential of microalga Isochrysis galbana: Bioactivity and bioaccessibility |
title |
Potential of microalga Isochrysis galbana: Bioactivity and bioaccessibility |
spellingShingle |
Potential of microalga Isochrysis galbana: Bioactivity and bioaccessibility Bonfanti, C. [UNESP] Anti-inflammatory activity Bioaccessibility Isochrysis galbana Lipid composition ω3 PUFA |
title_short |
Potential of microalga Isochrysis galbana: Bioactivity and bioaccessibility |
title_full |
Potential of microalga Isochrysis galbana: Bioactivity and bioaccessibility |
title_fullStr |
Potential of microalga Isochrysis galbana: Bioactivity and bioaccessibility |
title_full_unstemmed |
Potential of microalga Isochrysis galbana: Bioactivity and bioaccessibility |
title_sort |
Potential of microalga Isochrysis galbana: Bioactivity and bioaccessibility |
author |
Bonfanti, C. [UNESP] |
author_facet |
Bonfanti, C. [UNESP] Cardoso, C. Afonso, C. Matos, J. Garcia, T. [UNESP] Tanni, S. [UNESP] Bandarra, N. M. |
author_role |
author |
author2 |
Cardoso, C. Afonso, C. Matos, J. Garcia, T. [UNESP] Tanni, S. [UNESP] Bandarra, N. M. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) IP) University of Porto Faculdade de Ciências da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Bonfanti, C. [UNESP] Cardoso, C. Afonso, C. Matos, J. Garcia, T. [UNESP] Tanni, S. [UNESP] Bandarra, N. M. |
dc.subject.por.fl_str_mv |
Anti-inflammatory activity Bioaccessibility Isochrysis galbana Lipid composition ω3 PUFA |
topic |
Anti-inflammatory activity Bioaccessibility Isochrysis galbana Lipid composition ω3 PUFA |
description |
The lipid composition and anti-inflammatory activity of the microalga Isochrysis galbana were studied. Moreover, the influence of bioaccessibility on composition and bioactivity was evaluated through the application of an in vitro model of the human digestion. The fatty acid (FA) profile was characterized by abundance of polyunsaturated FA (PUFA) and, within PUFA, ω3 PUFA were the most abundant. High contents of myristic, oleic, linoleic, α-linolenic, and stearidonic acids as well as docosahexaenoic acid (DHA) were determined. A low level of hydrolysis of triacylglycerols (TAGs) and polar lipids was observed during digestion. Total lipid bioaccessibility and specific FA bioaccessibility were low (between 7 and 15%). The highest bioaccessibility percentages were determined for palmitic, oleic, and linoleic acids as well as total ω6 PUFA and the lowest bioaccessible percentages were calculated for myristic and stearidonic acids, DHA, and total ω3 PUFA. Chemical affinity phenomena could be an explanation for these results. Regarding anti-inflammatory activity, it was only detected in the lipid extract of I. galbana prior to digestion (79 ± 7% of cyclooxygenase-2, COX-2, inhibition). No activity was found in the bioaccessible fraction extract. Apparently, the COX-2 inhibitory compounds were not rendered bioaccessible. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T16:50:48Z 2018-12-11T16:50:48Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.algal.2017.11.035 Algal Research, v. 29, p. 242-248. 2211-9264 http://hdl.handle.net/11449/170437 10.1016/j.algal.2017.11.035 2-s2.0-85036494985 2-s2.0-85036494985.pdf |
url |
http://dx.doi.org/10.1016/j.algal.2017.11.035 http://hdl.handle.net/11449/170437 |
identifier_str_mv |
Algal Research, v. 29, p. 242-248. 2211-9264 10.1016/j.algal.2017.11.035 2-s2.0-85036494985 2-s2.0-85036494985.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Algal Research 1,142 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
242-248 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128695621124096 |