Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jevs.2015.10.014 http://hdl.handle.net/11449/173202 |
Resumo: | Catecholamines and arginine vasopressin (AVP) release can affect arterial blood pressure (ABP) and hemodynamic stability in standing, sedated horses. Six mature horses were included in this prospective, randomized, crossover, blinded, experimental study. All the horses were sedated with detomidine (DET) alone (0.01 mg/kg, IV) or combined with methadone (MET) (0.01 mg/kg DET and 0.2 mg/kg MET, IV). Cardiopulmonary data and blood samples were collected 30 minutes before (prebaseline and baseline) and for 120 minutes postinjection. The combination DET/MET produced a significant increase (31%) in mean ABP (MAP) 5 minutes after drug administration which lasted for 120 minutes. Detomidine alone induced only a short-term increase in MAP (15%) at 5 minutes compared with baseline. There were significant differences between groups at 5, 15, and from 60 to 120 minutes. Plasma AVP concentrations were higher in horses receiving the treatment DET from 60 to 120 minutes than those in the combination group, for the same period. There were no significant differences in norepinephrine and epinephrine serum concentrations respect to baseline and between treatments. Detomidine induces a short-term MAP increase, and this effect was prolonged and potentiated by MET association. There is no evidence of AVP, norepinephrine, and epinephrine involvement in this effect. |
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Repositório Institucional da UNESP |
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Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of CatecholaminesAdrenergic alpha-2 agonistAnalgesicArterial blood pressureCardiovascular systemEquineOpioidCatecholamines and arginine vasopressin (AVP) release can affect arterial blood pressure (ABP) and hemodynamic stability in standing, sedated horses. Six mature horses were included in this prospective, randomized, crossover, blinded, experimental study. All the horses were sedated with detomidine (DET) alone (0.01 mg/kg, IV) or combined with methadone (MET) (0.01 mg/kg DET and 0.2 mg/kg MET, IV). Cardiopulmonary data and blood samples were collected 30 minutes before (prebaseline and baseline) and for 120 minutes postinjection. The combination DET/MET produced a significant increase (31%) in mean ABP (MAP) 5 minutes after drug administration which lasted for 120 minutes. Detomidine alone induced only a short-term increase in MAP (15%) at 5 minutes compared with baseline. There were significant differences between groups at 5, 15, and from 60 to 120 minutes. Plasma AVP concentrations were higher in horses receiving the treatment DET from 60 to 120 minutes than those in the combination group, for the same period. There were no significant differences in norepinephrine and epinephrine serum concentrations respect to baseline and between treatments. Detomidine induces a short-term MAP increase, and this effect was prolonged and potentiated by MET association. There is no evidence of AVP, norepinephrine, and epinephrine involvement in this effect.Department of Anesthesiology School of Medicine UNESP—Univ Estadual PaulistaDepartment of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science UNESP—Univ Estadual PaulistaDepartment of Biochemistry Escola Paulista de Medicina Federal University of São PauloDepartment of Anesthesiology School of Medicine UNESP—Univ Estadual PaulistaDepartment of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science UNESP—Univ Estadual PaulistaUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Pignaton, Wangles [UNESP]Luna, Stelio Pacca Loureiro [UNESP]Teixeira Neto, Francisco José [UNESP]Oliveira, Flávia Augusta de [UNESP]Castro Neto, Eduardo Ferreira deGraça Naffah-Mazzacoratti, Maria daGozalo-Marcilla, Miguel [UNESP]2018-12-11T17:04:07Z2018-12-11T17:04:07Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article39-45application/pdfhttp://dx.doi.org/10.1016/j.jevs.2015.10.014Journal of Equine Veterinary Science, v. 37, p. 39-45.0737-0806http://hdl.handle.net/11449/17320210.1016/j.jevs.2015.10.0142-s2.0-849776674732-s2.0-84977667473.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Equine Veterinary Science0,390info:eu-repo/semantics/openAccess2023-12-23T06:20:30Zoai:repositorio.unesp.br:11449/173202Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:06:38.754689Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines |
title |
Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines |
spellingShingle |
Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines Pignaton, Wangles [UNESP] Adrenergic alpha-2 agonist Analgesic Arterial blood pressure Cardiovascular system Equine Opioid |
title_short |
Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines |
title_full |
Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines |
title_fullStr |
Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines |
title_full_unstemmed |
Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines |
title_sort |
Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines |
author |
Pignaton, Wangles [UNESP] |
author_facet |
Pignaton, Wangles [UNESP] Luna, Stelio Pacca Loureiro [UNESP] Teixeira Neto, Francisco José [UNESP] Oliveira, Flávia Augusta de [UNESP] Castro Neto, Eduardo Ferreira de Graça Naffah-Mazzacoratti, Maria da Gozalo-Marcilla, Miguel [UNESP] |
author_role |
author |
author2 |
Luna, Stelio Pacca Loureiro [UNESP] Teixeira Neto, Francisco José [UNESP] Oliveira, Flávia Augusta de [UNESP] Castro Neto, Eduardo Ferreira de Graça Naffah-Mazzacoratti, Maria da Gozalo-Marcilla, Miguel [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Pignaton, Wangles [UNESP] Luna, Stelio Pacca Loureiro [UNESP] Teixeira Neto, Francisco José [UNESP] Oliveira, Flávia Augusta de [UNESP] Castro Neto, Eduardo Ferreira de Graça Naffah-Mazzacoratti, Maria da Gozalo-Marcilla, Miguel [UNESP] |
dc.subject.por.fl_str_mv |
Adrenergic alpha-2 agonist Analgesic Arterial blood pressure Cardiovascular system Equine Opioid |
topic |
Adrenergic alpha-2 agonist Analgesic Arterial blood pressure Cardiovascular system Equine Opioid |
description |
Catecholamines and arginine vasopressin (AVP) release can affect arterial blood pressure (ABP) and hemodynamic stability in standing, sedated horses. Six mature horses were included in this prospective, randomized, crossover, blinded, experimental study. All the horses were sedated with detomidine (DET) alone (0.01 mg/kg, IV) or combined with methadone (MET) (0.01 mg/kg DET and 0.2 mg/kg MET, IV). Cardiopulmonary data and blood samples were collected 30 minutes before (prebaseline and baseline) and for 120 minutes postinjection. The combination DET/MET produced a significant increase (31%) in mean ABP (MAP) 5 minutes after drug administration which lasted for 120 minutes. Detomidine alone induced only a short-term increase in MAP (15%) at 5 minutes compared with baseline. There were significant differences between groups at 5, 15, and from 60 to 120 minutes. Plasma AVP concentrations were higher in horses receiving the treatment DET from 60 to 120 minutes than those in the combination group, for the same period. There were no significant differences in norepinephrine and epinephrine serum concentrations respect to baseline and between treatments. Detomidine induces a short-term MAP increase, and this effect was prolonged and potentiated by MET association. There is no evidence of AVP, norepinephrine, and epinephrine involvement in this effect. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2018-12-11T17:04:07Z 2018-12-11T17:04:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jevs.2015.10.014 Journal of Equine Veterinary Science, v. 37, p. 39-45. 0737-0806 http://hdl.handle.net/11449/173202 10.1016/j.jevs.2015.10.014 2-s2.0-84977667473 2-s2.0-84977667473.pdf |
url |
http://dx.doi.org/10.1016/j.jevs.2015.10.014 http://hdl.handle.net/11449/173202 |
identifier_str_mv |
Journal of Equine Veterinary Science, v. 37, p. 39-45. 0737-0806 10.1016/j.jevs.2015.10.014 2-s2.0-84977667473 2-s2.0-84977667473.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Equine Veterinary Science 0,390 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
39-45 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129285374869504 |