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Treatment of venous ulcers with fibrin sealant derived from snake venom

Detalhes bibliográficos
Autor(a) principal: Gatti, M. A.N.
Data de Publicação: 2011
Outros Autores: Vieira, L. M., Barraviera, B. [UNESP], Barraviera, S. R.C.S. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1678-91992011000200015
http://hdl.handle.net/11449/226352
Resumo: Venous ulcers of the lower limbs complicated by infection or chronicity represent a serious public health problem. The elevated number of those afflicted burdens the health services, interferes in quality of life and causes absenteeism. Although there are 2,500 items on the market, ranging from the simplest dressing up to the most complex types of dressing, treatment remains a challenge. Among the substances used, fibrin sealant is the one that promotes diminution of bacterial colonization and of edema, controls hemorrhaging, alters the pain threshold by protecting the nerve endings, hydrates the wound bed and forms granulation tissue that favors healing. Its disadvantages include higher cost and utilization of human fibrinogen that can transmit infectious diseases. The Center for the Study of Venoms and Venomous Animals (CEVAP) at São Paulo State University (UNESP) developed a new sealant made up of fibrinogen extracted from large animals and from an enzyme obtained from snake venom. The present study, developed in the Health Education Clinic (CEPS) of Sacred Heart University (USC) aimed to evaluate the effect of the new sealant on the healing process of venous ulcers in 24 adult patients, seven of whom were male and 17 female. Two study groups were formed as follows: Group 1 (G1) - control group of 11 patients treated with essential fatty acid (EFA) and Unna's boot, and Group 2 (G2) - 13 patients treated with essential fatty acid (EFA), fibrin sealant and Unna's boot. The follow-up lasted eight weeks and the sealant was applied at only the first and fourth weeks. The results showed that Group 2 presented worse lesion conditions as to healing, but, when comparing the two groups, it was noteworthy that the the sealant was effective in healing venous ulcers. There is evidence that the new sealant is recommended for leg ulcers with the following advantages: ease of application, preparation of the wound bed, diminution of pain and a higher number of discharges in the eighth week. More important, other positive characteristics are non-transmission of infectious diseases, absence of adverse reactions, and economic advantage of being produced by Brazilian technology. Finally, it is suggested that the weekly applic. © CEVAP 2011.
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spelling Treatment of venous ulcers with fibrin sealant derived from snake venomFibrin sealantHealingVenous ulcersWoundsVenous ulcers of the lower limbs complicated by infection or chronicity represent a serious public health problem. The elevated number of those afflicted burdens the health services, interferes in quality of life and causes absenteeism. Although there are 2,500 items on the market, ranging from the simplest dressing up to the most complex types of dressing, treatment remains a challenge. Among the substances used, fibrin sealant is the one that promotes diminution of bacterial colonization and of edema, controls hemorrhaging, alters the pain threshold by protecting the nerve endings, hydrates the wound bed and forms granulation tissue that favors healing. Its disadvantages include higher cost and utilization of human fibrinogen that can transmit infectious diseases. The Center for the Study of Venoms and Venomous Animals (CEVAP) at São Paulo State University (UNESP) developed a new sealant made up of fibrinogen extracted from large animals and from an enzyme obtained from snake venom. The present study, developed in the Health Education Clinic (CEPS) of Sacred Heart University (USC) aimed to evaluate the effect of the new sealant on the healing process of venous ulcers in 24 adult patients, seven of whom were male and 17 female. Two study groups were formed as follows: Group 1 (G1) - control group of 11 patients treated with essential fatty acid (EFA) and Unna's boot, and Group 2 (G2) - 13 patients treated with essential fatty acid (EFA), fibrin sealant and Unna's boot. The follow-up lasted eight weeks and the sealant was applied at only the first and fourth weeks. The results showed that Group 2 presented worse lesion conditions as to healing, but, when comparing the two groups, it was noteworthy that the the sealant was effective in healing venous ulcers. There is evidence that the new sealant is recommended for leg ulcers with the following advantages: ease of application, preparation of the wound bed, diminution of pain and a higher number of discharges in the eighth week. More important, other positive characteristics are non-transmission of infectious diseases, absence of adverse reactions, and economic advantage of being produced by Brazilian technology. Finally, it is suggested that the weekly applic. © CEVAP 2011.Health Education Clinic, CEPS Sacred Heart University, USC, Bauru, São Paulo StateDepartment of Tropical Diseases and Imaging Diagnosis Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São PauloThe Center for the Study of Venoms and Venomous Animals, CEVAP São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São PauloDepartment of Dermatology and Radiotherapy Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São PauloDepartment of Tropical Diseases and Imaging Diagnosis Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São PauloThe Center for the Study of Venoms and Venomous Animals, CEVAP São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São PauloDepartment of Dermatology and Radiotherapy Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São PauloSacred Heart University, USCUniversidade Estadual Paulista (UNESP)Gatti, M. A.N.Vieira, L. M.Barraviera, B. [UNESP]Barraviera, S. R.C.S. [UNESP]2022-04-28T22:37:25Z2022-04-28T22:37:25Z2011-06-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article226-229http://dx.doi.org/10.1590/S1678-91992011000200015Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 17, n. 2, p. 226-229, 2011.1678-9199http://hdl.handle.net/11449/22635210.1590/S1678-919920110002000152-s2.0-79958124511Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseasesinfo:eu-repo/semantics/openAccess2024-08-15T15:22:47Zoai:repositorio.unesp.br:11449/226352Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:22:47Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Treatment of venous ulcers with fibrin sealant derived from snake venom
title Treatment of venous ulcers with fibrin sealant derived from snake venom
spellingShingle Treatment of venous ulcers with fibrin sealant derived from snake venom
Gatti, M. A.N.
Fibrin sealant
Healing
Venous ulcers
Wounds
title_short Treatment of venous ulcers with fibrin sealant derived from snake venom
title_full Treatment of venous ulcers with fibrin sealant derived from snake venom
title_fullStr Treatment of venous ulcers with fibrin sealant derived from snake venom
title_full_unstemmed Treatment of venous ulcers with fibrin sealant derived from snake venom
title_sort Treatment of venous ulcers with fibrin sealant derived from snake venom
author Gatti, M. A.N.
author_facet Gatti, M. A.N.
Vieira, L. M.
Barraviera, B. [UNESP]
Barraviera, S. R.C.S. [UNESP]
author_role author
author2 Vieira, L. M.
Barraviera, B. [UNESP]
Barraviera, S. R.C.S. [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Sacred Heart University, USC
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Gatti, M. A.N.
Vieira, L. M.
Barraviera, B. [UNESP]
Barraviera, S. R.C.S. [UNESP]
dc.subject.por.fl_str_mv Fibrin sealant
Healing
Venous ulcers
Wounds
topic Fibrin sealant
Healing
Venous ulcers
Wounds
description Venous ulcers of the lower limbs complicated by infection or chronicity represent a serious public health problem. The elevated number of those afflicted burdens the health services, interferes in quality of life and causes absenteeism. Although there are 2,500 items on the market, ranging from the simplest dressing up to the most complex types of dressing, treatment remains a challenge. Among the substances used, fibrin sealant is the one that promotes diminution of bacterial colonization and of edema, controls hemorrhaging, alters the pain threshold by protecting the nerve endings, hydrates the wound bed and forms granulation tissue that favors healing. Its disadvantages include higher cost and utilization of human fibrinogen that can transmit infectious diseases. The Center for the Study of Venoms and Venomous Animals (CEVAP) at São Paulo State University (UNESP) developed a new sealant made up of fibrinogen extracted from large animals and from an enzyme obtained from snake venom. The present study, developed in the Health Education Clinic (CEPS) of Sacred Heart University (USC) aimed to evaluate the effect of the new sealant on the healing process of venous ulcers in 24 adult patients, seven of whom were male and 17 female. Two study groups were formed as follows: Group 1 (G1) - control group of 11 patients treated with essential fatty acid (EFA) and Unna's boot, and Group 2 (G2) - 13 patients treated with essential fatty acid (EFA), fibrin sealant and Unna's boot. The follow-up lasted eight weeks and the sealant was applied at only the first and fourth weeks. The results showed that Group 2 presented worse lesion conditions as to healing, but, when comparing the two groups, it was noteworthy that the the sealant was effective in healing venous ulcers. There is evidence that the new sealant is recommended for leg ulcers with the following advantages: ease of application, preparation of the wound bed, diminution of pain and a higher number of discharges in the eighth week. More important, other positive characteristics are non-transmission of infectious diseases, absence of adverse reactions, and economic advantage of being produced by Brazilian technology. Finally, it is suggested that the weekly applic. © CEVAP 2011.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-13
2022-04-28T22:37:25Z
2022-04-28T22:37:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1678-91992011000200015
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 17, n. 2, p. 226-229, 2011.
1678-9199
http://hdl.handle.net/11449/226352
10.1590/S1678-91992011000200015
2-s2.0-79958124511
url http://dx.doi.org/10.1590/S1678-91992011000200015
http://hdl.handle.net/11449/226352
identifier_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 17, n. 2, p. 226-229, 2011.
1678-9199
10.1590/S1678-91992011000200015
2-s2.0-79958124511
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 226-229
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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