Atividade Antinociceptiva e Antimicrobiana da Casca do Caule de Psidium Cattleyanum Sabine

• Autor(a) principal: Alvarenda, F.q.
• Data de Publicação: 2015
• Outros Autores: Royo, V.a., Mota, B.f.c., Laurentiz, R.s., Menezes, E.v., Melo Junior, A.f., Oliveira, D.a.
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/1983-084x/14_146; http://hdl.handle.net/11449/158133
• topic: Myrtaceae; araçá; biological activity; inhibition algic; antibacterial activity; Myrtaceae; araçá; atividade biológica; inibição álgica; atividade antibacteriana

ABSTRACT The Psidium cattleyanum Sabine, known as “araçá”, is a native species from the Brazilian Cerrado biome, commonly used, according to ethnobotanical surveis, as a medicinal plant to treat several sicknesses such as liver and , gastric diseases and tissue lesions with painful treatments. The aim of this study was to perform an exploratory screening, investigating the analgesic and antimicrobial activity of the hydroalcoholic extract of the Psidium cattleyanum Sabine (BEPCS) stem bark, in order to support the use of this species as a medicinal plant. For that, the BEPCS and its parts were obtained from the extraction with organic solvents of increasing polarity (hexane, dichloromethane, ethyl acetate and isobutanol), evaluating its phytochemical profile in order to determine the main types of secondary metabolites present in the species. The analgesic activity, through the twisting test in mice, was investigated and induced by acetic acid (0.6%). The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were evaluated using the microdilution technique in liquid against microorganisms of the oral microbiota. The phytochemical screening identified the presence of tannins, saponins, flavonoids and terpenes and/or steroids. The BEPCS exhibited peripheral analgesic activity at the doses of 200 and 400 mg / kg. The AEB (acetate extract bark) and the DEB (dicloromethane extract bark) had better inhibitory effect on bacterial growth of Staphylococcus oraliswith MIC 100 and 150 respectively. The BEPCS demonstrated an inhibitory effect on bacterial growth. The results of experimental studies have indicated the presence of secondary compounds as tannins and flavonoids, which probably can be associated with the analgesic activity and inhibitory effect on the microorganisms tested with BEPCS, fact that justifies the its application.