Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4137/CMWH.S17853 http://hdl.handle.net/11449/130974 |
Resumo: | This is a qualitative-quantitative study based on hospital records of female patients of reproductive age, presenting sexual dysfunction, and treated with 250 mg Tribulus terrestris extract (1 tablet thrice daily for 90 days). Safety monitoring included vital signs, physical examination, laboratory tests, and occurrence of adverse events. Efficacy analysis included results of the Female Sexual Function Index (FSFI), dehydroepiandrosterone (DHEA) levels together with total and free testosterone, and the patient and physician assessments. There was a statistically significant improvement in total FSFI scores (P < 0.0001) post-treatment, with improvement among 106 (88.33%) subjects. There was a statistically significant (P < 0.0001) increase in the level of DHEA, while the levels of both serum testosterone (P = 0.284) and free testosterone decreased (P < 0.0001). Most adverse events recorded were related to the gastrointestinal tract. Physical examination showed no significant changes post-treatment. Based on the results, it is concluded that the T. terrestris extract is safe and effective in the treatment of female sexual dysfunction. |
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Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual DysfunctionTribulus terrestrisFemale sexual dysfunctionFemale sexual function indexThis is a qualitative-quantitative study based on hospital records of female patients of reproductive age, presenting sexual dysfunction, and treated with 250 mg Tribulus terrestris extract (1 tablet thrice daily for 90 days). Safety monitoring included vital signs, physical examination, laboratory tests, and occurrence of adverse events. Efficacy analysis included results of the Female Sexual Function Index (FSFI), dehydroepiandrosterone (DHEA) levels together with total and free testosterone, and the patient and physician assessments. There was a statistically significant improvement in total FSFI scores (P < 0.0001) post-treatment, with improvement among 106 (88.33%) subjects. There was a statistically significant (P < 0.0001) increase in the level of DHEA, while the levels of both serum testosterone (P = 0.284) and free testosterone decreased (P < 0.0001). Most adverse events recorded were related to the gastrointestinal tract. Physical examination showed no significant changes post-treatment. Based on the results, it is concluded that the T. terrestris extract is safe and effective in the treatment of female sexual dysfunction.Departamento de Ginecologia, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrasilDepartamento deGinecologia, Fundação Educacional Serra dos Órgãos (UNIFESO), Teresópolis, RJ, BrasilColégio Brasileiro de Cirurgiões, Rio de Janeiro, RJ, BrasilDepartamento de Endoscopia Ginecológica, Fundação Educacional Serra dos Órgãos (UNIFESO), Teresópolis, RJ, BrasilDepartamento de Ginecologia, Universidade Federal Fluminense (UFF), Rio de Janeiro, RJ, BrasilDepartamento de Ginecologia e Obstetrícia, Hospital das Clínicas, Fundação Educacional Serra dos Órgãos, Teresópolis, RJ, BrasilDepartamento de Farmacologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrasilDepartamento de Medicina Interna, Fundação Educacional Serra dos Órgãos (UNIFESO), Teresópolis, RJ, BrasilDepartamento de Imunologia Clínica, Instituto de Pós-Graduação Médica Carlos Chagas (IPGMCC), Rio de Janeiro, RJ, BrasilDepartamento de Imunologia, Fundação Educacional Serra dos Órgãos (UNIFESO), Teresópolis, RJ, BrasilDepartamento de Genética clínica, Universidade Federal do Rio de Janeiro, RJ, BrasilUniversidade Estadual Paulista, Departamento de Ginecologia, Faculdade de Medicina de BotucatuLibertas Academica LtdUniversidade Estadual Paulista (Unesp)Fundação Educacional Serra dos Órgãos (UNIFESO)Colégio Brasileiro de Cirurgiões (CBC)Universidade Federal Fluminense (UFF)Universidade Federal do Rio de Janeiro (UFRJ)Instituto de Pós-Graduação Médica Carlos Chagas (IPGMCC)Gama, Carlos R. B. [UNESP]Lasmar, Ricardo [UNESP]Gama, Gustavo F.Abreu, Camila S.Nunes, Carlos P.Geller, MauroOliveira, LisaSantos, Alessandra2015-12-07T15:30:32Z2015-12-07T15:30:32Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article45-50application/pdfhttp://dx.doi.org/10.4137/CMWH.S17853Clinical Medicine Insights. Women's Health, v. 7, p. 45-50, 2014.1179-562Xhttp://hdl.handle.net/11449/13097410.4137/CMWH.S17853PMC4275110.pdf25574150PMC4275110PubMedreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Medicine Insights. Women's Healthinfo:eu-repo/semantics/openAccess2023-12-27T06:17:31Zoai:repositorio.unesp.br:11449/130974Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-27T06:17:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction |
title |
Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction |
spellingShingle |
Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction Gama, Carlos R. B. [UNESP] Tribulus terrestris Female sexual dysfunction Female sexual function index |
title_short |
Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction |
title_full |
Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction |
title_fullStr |
Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction |
title_full_unstemmed |
Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction |
title_sort |
Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction |
author |
Gama, Carlos R. B. [UNESP] |
author_facet |
Gama, Carlos R. B. [UNESP] Lasmar, Ricardo [UNESP] Gama, Gustavo F. Abreu, Camila S. Nunes, Carlos P. Geller, Mauro Oliveira, Lisa Santos, Alessandra |
author_role |
author |
author2 |
Lasmar, Ricardo [UNESP] Gama, Gustavo F. Abreu, Camila S. Nunes, Carlos P. Geller, Mauro Oliveira, Lisa Santos, Alessandra |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Fundação Educacional Serra dos Órgãos (UNIFESO) Colégio Brasileiro de Cirurgiões (CBC) Universidade Federal Fluminense (UFF) Universidade Federal do Rio de Janeiro (UFRJ) Instituto de Pós-Graduação Médica Carlos Chagas (IPGMCC) |
dc.contributor.author.fl_str_mv |
Gama, Carlos R. B. [UNESP] Lasmar, Ricardo [UNESP] Gama, Gustavo F. Abreu, Camila S. Nunes, Carlos P. Geller, Mauro Oliveira, Lisa Santos, Alessandra |
dc.subject.por.fl_str_mv |
Tribulus terrestris Female sexual dysfunction Female sexual function index |
topic |
Tribulus terrestris Female sexual dysfunction Female sexual function index |
description |
This is a qualitative-quantitative study based on hospital records of female patients of reproductive age, presenting sexual dysfunction, and treated with 250 mg Tribulus terrestris extract (1 tablet thrice daily for 90 days). Safety monitoring included vital signs, physical examination, laboratory tests, and occurrence of adverse events. Efficacy analysis included results of the Female Sexual Function Index (FSFI), dehydroepiandrosterone (DHEA) levels together with total and free testosterone, and the patient and physician assessments. There was a statistically significant improvement in total FSFI scores (P < 0.0001) post-treatment, with improvement among 106 (88.33%) subjects. There was a statistically significant (P < 0.0001) increase in the level of DHEA, while the levels of both serum testosterone (P = 0.284) and free testosterone decreased (P < 0.0001). Most adverse events recorded were related to the gastrointestinal tract. Physical examination showed no significant changes post-treatment. Based on the results, it is concluded that the T. terrestris extract is safe and effective in the treatment of female sexual dysfunction. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2015-12-07T15:30:32Z 2015-12-07T15:30:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4137/CMWH.S17853 Clinical Medicine Insights. Women's Health, v. 7, p. 45-50, 2014. 1179-562X http://hdl.handle.net/11449/130974 10.4137/CMWH.S17853 PMC4275110.pdf 25574150 PMC4275110 |
url |
http://dx.doi.org/10.4137/CMWH.S17853 http://hdl.handle.net/11449/130974 |
identifier_str_mv |
Clinical Medicine Insights. Women's Health, v. 7, p. 45-50, 2014. 1179-562X 10.4137/CMWH.S17853 PMC4275110.pdf 25574150 PMC4275110 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Medicine Insights. Women's Health |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
45-50 application/pdf |
dc.publisher.none.fl_str_mv |
Libertas Academica Ltd |
publisher.none.fl_str_mv |
Libertas Academica Ltd |
dc.source.none.fl_str_mv |
PubMed reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965419873763328 |