State of methylation and epigenome studies in some types of head and neck cancer

Detalhes bibliográficos
Autor(a) principal: Bonar-Alvarez, P.
Data de Publicação: 2018
Outros Autores: Perez-Sayans, Mario, Padín-Iruegas, E., Suarez-Penaranda, J. M., Oliveira-Alves, M. [UNESP], Blanco Carrion, A., García-Garcia, A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/221154
Resumo: Oral Squamous Cell Carcinomas (OSCC) are one of the most frequent cancers in the world. This term is used to describe malignant tumors of the oral cavity, pharynx and larynx, with a high incidence and mortality. Deregulation of genetic expression is a common process; however, to this we must also add epigenetic modifications, which consist of histone changes, altered expression of miRNAs and aberrant DNA methylation. The main purpose of this study is to review the methylation promoter genes in OSCC and to determine the degree of methylation in these types of tumors, in addition to analyzing the latest studies on the usefulness of these genes as epigenetic markers for early detection and to determine the recurrence of the disease and offer new treatment options.
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spelling State of methylation and epigenome studies in some types of head and neck cancerEpigeneticsMethylationOral cancerOral squamous cell carcinoma (OSCC)Panel of biomarkersOral Squamous Cell Carcinomas (OSCC) are one of the most frequent cancers in the world. This term is used to describe malignant tumors of the oral cavity, pharynx and larynx, with a high incidence and mortality. Deregulation of genetic expression is a common process; however, to this we must also add epigenetic modifications, which consist of histone changes, altered expression of miRNAs and aberrant DNA methylation. The main purpose of this study is to review the methylation promoter genes in OSCC and to determine the degree of methylation in these types of tumors, in addition to analyzing the latest studies on the usefulness of these genes as epigenetic markers for early detection and to determine the recurrence of the disease and offer new treatment options.Oral Medicine Oral Surgery and Implantology UnitHuman Anatomy and Embryology Area Department of Functional Biology and Health SciencesPathology and Anatomy Unit Hospital Clinico Universitario de Santiago, Choupana s/nFaculdade de Odontologia de São José dos Campos Universidade Estadual Paulista Júlio de Mesquita FilhoFaculdade de Odontologia de São José dos Campos Universidade Estadual Paulista Júlio de Mesquita FilhoOral Surgery and Implantology UnitHuman Anatomy and Embryology AreaHospital Clinico Universitario de SantiagoUniversidade Estadual Paulista (UNESP)Bonar-Alvarez, P.Perez-Sayans, MarioPadín-Iruegas, E.Suarez-Penaranda, J. M.Oliveira-Alves, M. [UNESP]Blanco Carrion, A.García-Garcia, A.2022-04-28T19:11:03Z2022-04-28T19:11:03Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2944-2955Biomedical Research (India), v. 29, n. 14, p. 2944-2955, 2018.0970-938Xhttp://hdl.handle.net/11449/2211542-s2.0-85052727082Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiomedical Research (India)info:eu-repo/semantics/openAccess2022-04-28T19:11:03Zoai:repositorio.unesp.br:11449/221154Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:54:41.805898Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv State of methylation and epigenome studies in some types of head and neck cancer
title State of methylation and epigenome studies in some types of head and neck cancer
spellingShingle State of methylation and epigenome studies in some types of head and neck cancer
Bonar-Alvarez, P.
Epigenetics
Methylation
Oral cancer
Oral squamous cell carcinoma (OSCC)
Panel of biomarkers
title_short State of methylation and epigenome studies in some types of head and neck cancer
title_full State of methylation and epigenome studies in some types of head and neck cancer
title_fullStr State of methylation and epigenome studies in some types of head and neck cancer
title_full_unstemmed State of methylation and epigenome studies in some types of head and neck cancer
title_sort State of methylation and epigenome studies in some types of head and neck cancer
author Bonar-Alvarez, P.
author_facet Bonar-Alvarez, P.
Perez-Sayans, Mario
Padín-Iruegas, E.
Suarez-Penaranda, J. M.
Oliveira-Alves, M. [UNESP]
Blanco Carrion, A.
García-Garcia, A.
author_role author
author2 Perez-Sayans, Mario
Padín-Iruegas, E.
Suarez-Penaranda, J. M.
Oliveira-Alves, M. [UNESP]
Blanco Carrion, A.
García-Garcia, A.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Oral Surgery and Implantology Unit
Human Anatomy and Embryology Area
Hospital Clinico Universitario de Santiago
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Bonar-Alvarez, P.
Perez-Sayans, Mario
Padín-Iruegas, E.
Suarez-Penaranda, J. M.
Oliveira-Alves, M. [UNESP]
Blanco Carrion, A.
García-Garcia, A.
dc.subject.por.fl_str_mv Epigenetics
Methylation
Oral cancer
Oral squamous cell carcinoma (OSCC)
Panel of biomarkers
topic Epigenetics
Methylation
Oral cancer
Oral squamous cell carcinoma (OSCC)
Panel of biomarkers
description Oral Squamous Cell Carcinomas (OSCC) are one of the most frequent cancers in the world. This term is used to describe malignant tumors of the oral cavity, pharynx and larynx, with a high incidence and mortality. Deregulation of genetic expression is a common process; however, to this we must also add epigenetic modifications, which consist of histone changes, altered expression of miRNAs and aberrant DNA methylation. The main purpose of this study is to review the methylation promoter genes in OSCC and to determine the degree of methylation in these types of tumors, in addition to analyzing the latest studies on the usefulness of these genes as epigenetic markers for early detection and to determine the recurrence of the disease and offer new treatment options.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
2022-04-28T19:11:03Z
2022-04-28T19:11:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Biomedical Research (India), v. 29, n. 14, p. 2944-2955, 2018.
0970-938X
http://hdl.handle.net/11449/221154
2-s2.0-85052727082
identifier_str_mv Biomedical Research (India), v. 29, n. 14, p. 2944-2955, 2018.
0970-938X
2-s2.0-85052727082
url http://hdl.handle.net/11449/221154
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biomedical Research (India)
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2944-2955
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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