In vitro antifungal susceptibility of Candida spp. isolates from patients with chronic periodontitis and from control patients
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1806-83242004000100015 http://hdl.handle.net/11449/67609 |
Resumo: | Superinfection by Candida can be refractory to conventional periodontal treatments in specific situations, such as in immunocompromised patients. In these cases, the systemic therapy with antifungal drugs could be indicated. The aim of this study was to analyse antifungal susceptibility of Candida spp. strains isolated from chronic periodontitis patients and from control individuals. A total of 39 C. albicans isolates, 9 C. tropicalis, 2 C. glabrata and 5 Candida spp. from control individuals and 30 C. albicans, 3 C. tropicalis and 2 C. glabrata from periodontitis patients were tested. In the control group, 1 isolate of C. glabrata was resistant to ketoconazole and 1 Candida spp. was resistant to amphotericin B, ketoconazole and miconazole. Among the isolates of periodontitis group, 1 (3.33%) C. albicans isolate was resistant to flucytosine and ketoconazole. According to the obtained results, it could be concluded that fluconazole was the most effective drug against the several Candida species studied. There were not expressive differences in the susceptibility of isolates from periodontitis patients or from control individuals. |
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In vitro antifungal susceptibility of Candida spp. isolates from patients with chronic periodontitis and from control patientsantifungal agentfluconazoleflucytosineketoconazolemiconazoleadultCandidacase control studydrug effecthumanisolation and purificationmicrobiological examinationmicrobiologymiddle agedperiodontitisAdultAntifungal AgentsCase-Control StudiesFluconazoleFlucytosineHumansKetoconazoleMiconazoleMicrobial Sensitivity TestsMiddle AgedPeriodontitisSuperinfection by Candida can be refractory to conventional periodontal treatments in specific situations, such as in immunocompromised patients. In these cases, the systemic therapy with antifungal drugs could be indicated. The aim of this study was to analyse antifungal susceptibility of Candida spp. strains isolated from chronic periodontitis patients and from control individuals. A total of 39 C. albicans isolates, 9 C. tropicalis, 2 C. glabrata and 5 Candida spp. from control individuals and 30 C. albicans, 3 C. tropicalis and 2 C. glabrata from periodontitis patients were tested. In the control group, 1 isolate of C. glabrata was resistant to ketoconazole and 1 Candida spp. was resistant to amphotericin B, ketoconazole and miconazole. Among the isolates of periodontitis group, 1 (3.33%) C. albicans isolate was resistant to flucytosine and ketoconazole. According to the obtained results, it could be concluded that fluconazole was the most effective drug against the several Candida species studied. There were not expressive differences in the susceptibility of isolates from periodontitis patients or from control individuals.Universidade Estadual Paulista (Unesp)Koga-Ito, Cristiane YumiPaiva Martins, Clélia Aparecida deLoberto, Jussara Cia SanchesSantos, Silvana Soléo Ferreira dosJorge, Antonio Olavo Cardoso [UNESP]2014-05-27T11:21:01Z2014-05-27T11:21:01Z2004-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article80-84application/pdfhttp://dx.doi.org/10.1590/S1806-83242004000100015Pesquisa odontologica brasileira = Brazilian oral research, v. 18, n. 1, p. 80-84, 2004.1806-8324http://hdl.handle.net/11449/6760910.1590/S1806-83242004000100015S1806-832420040001000152-s2.0-166443652352-s2.0-16644365235.pdf005356715362356965435631614034210000-0002-2416-2173Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Odontológica Brasileira = Brazilian Oral Researchinfo:eu-repo/semantics/openAccess2023-11-06T06:07:37Zoai:repositorio.unesp.br:11449/67609Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-06T06:07:37Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In vitro antifungal susceptibility of Candida spp. isolates from patients with chronic periodontitis and from control patients |
title |
In vitro antifungal susceptibility of Candida spp. isolates from patients with chronic periodontitis and from control patients |
spellingShingle |
In vitro antifungal susceptibility of Candida spp. isolates from patients with chronic periodontitis and from control patients Koga-Ito, Cristiane Yumi antifungal agent fluconazole flucytosine ketoconazole miconazole adult Candida case control study drug effect human isolation and purification microbiological examination microbiology middle aged periodontitis Adult Antifungal Agents Case-Control Studies Fluconazole Flucytosine Humans Ketoconazole Miconazole Microbial Sensitivity Tests Middle Aged Periodontitis |
title_short |
In vitro antifungal susceptibility of Candida spp. isolates from patients with chronic periodontitis and from control patients |
title_full |
In vitro antifungal susceptibility of Candida spp. isolates from patients with chronic periodontitis and from control patients |
title_fullStr |
In vitro antifungal susceptibility of Candida spp. isolates from patients with chronic periodontitis and from control patients |
title_full_unstemmed |
In vitro antifungal susceptibility of Candida spp. isolates from patients with chronic periodontitis and from control patients |
title_sort |
In vitro antifungal susceptibility of Candida spp. isolates from patients with chronic periodontitis and from control patients |
author |
Koga-Ito, Cristiane Yumi |
author_facet |
Koga-Ito, Cristiane Yumi Paiva Martins, Clélia Aparecida de Loberto, Jussara Cia Sanches Santos, Silvana Soléo Ferreira dos Jorge, Antonio Olavo Cardoso [UNESP] |
author_role |
author |
author2 |
Paiva Martins, Clélia Aparecida de Loberto, Jussara Cia Sanches Santos, Silvana Soléo Ferreira dos Jorge, Antonio Olavo Cardoso [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Koga-Ito, Cristiane Yumi Paiva Martins, Clélia Aparecida de Loberto, Jussara Cia Sanches Santos, Silvana Soléo Ferreira dos Jorge, Antonio Olavo Cardoso [UNESP] |
dc.subject.por.fl_str_mv |
antifungal agent fluconazole flucytosine ketoconazole miconazole adult Candida case control study drug effect human isolation and purification microbiological examination microbiology middle aged periodontitis Adult Antifungal Agents Case-Control Studies Fluconazole Flucytosine Humans Ketoconazole Miconazole Microbial Sensitivity Tests Middle Aged Periodontitis |
topic |
antifungal agent fluconazole flucytosine ketoconazole miconazole adult Candida case control study drug effect human isolation and purification microbiological examination microbiology middle aged periodontitis Adult Antifungal Agents Case-Control Studies Fluconazole Flucytosine Humans Ketoconazole Miconazole Microbial Sensitivity Tests Middle Aged Periodontitis |
description |
Superinfection by Candida can be refractory to conventional periodontal treatments in specific situations, such as in immunocompromised patients. In these cases, the systemic therapy with antifungal drugs could be indicated. The aim of this study was to analyse antifungal susceptibility of Candida spp. strains isolated from chronic periodontitis patients and from control individuals. A total of 39 C. albicans isolates, 9 C. tropicalis, 2 C. glabrata and 5 Candida spp. from control individuals and 30 C. albicans, 3 C. tropicalis and 2 C. glabrata from periodontitis patients were tested. In the control group, 1 isolate of C. glabrata was resistant to ketoconazole and 1 Candida spp. was resistant to amphotericin B, ketoconazole and miconazole. Among the isolates of periodontitis group, 1 (3.33%) C. albicans isolate was resistant to flucytosine and ketoconazole. According to the obtained results, it could be concluded that fluconazole was the most effective drug against the several Candida species studied. There were not expressive differences in the susceptibility of isolates from periodontitis patients or from control individuals. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-01-01 2014-05-27T11:21:01Z 2014-05-27T11:21:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1806-83242004000100015 Pesquisa odontologica brasileira = Brazilian oral research, v. 18, n. 1, p. 80-84, 2004. 1806-8324 http://hdl.handle.net/11449/67609 10.1590/S1806-83242004000100015 S1806-83242004000100015 2-s2.0-16644365235 2-s2.0-16644365235.pdf 0053567153623569 6543563161403421 0000-0002-2416-2173 |
url |
http://dx.doi.org/10.1590/S1806-83242004000100015 http://hdl.handle.net/11449/67609 |
identifier_str_mv |
Pesquisa odontologica brasileira = Brazilian oral research, v. 18, n. 1, p. 80-84, 2004. 1806-8324 10.1590/S1806-83242004000100015 S1806-83242004000100015 2-s2.0-16644365235 2-s2.0-16644365235.pdf 0053567153623569 6543563161403421 0000-0002-2416-2173 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pesquisa Odontológica Brasileira = Brazilian Oral Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
80-84 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964834979119104 |