Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1177/1545968318805159 http://hdl.handle.net/11449/187056 |
Resumo: | Background. Aging is associated with declining mobility, which negatively affects quality of life and incurs substantial economic costs. Techniques to maintain safe mobility in older adults are therefore essential. Rhythmic auditory cueing (RAC) can improve walking patterns in older adults. However, the neural correlates associated with RAC, how they are influenced by repeated exposure and their relationships with gait response, cognitive function, and depressive symptoms are unclear. Objectives. This study aimed to investigate the effects of RAC during walking on cortical activation and the relationship between RAC-related cortical changes and cognitive function, depressive symptoms, and gait response. Methods. Seventeen young adults and eighteen older adults walked on a motorized treadmill for 5 minutes (5 trials with alternating 30-second blocks of usual walking and RAC walking). Changes in oxygenated hemoglobin (HbO 2 ) in the frontal cortex were recorded using functional near-infrared spectroscopy. Cognitive domains were assessed through validated tests. A triaxial accelerometer measured gait parameters. Results. Gait variability decreased and prefrontal HbO 2 levels increased during cued walking relative to usual walking. Older adults showed greater HbO 2 levels in multiple motor regions during cued walking although the response reduced with repeated exposure. In older adults, lower depression scores, higher cognitive functioning, and reduced gait variability were linked with increased HbO 2 levels during RAC walking. Conclusion. These findings suggest that walking improves with RAC in older adults and is achieved through increased activity in multiple cortical areas. The cortical response decline with repeated exposure indicates older adults’ ability to adapt to a new task. |
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Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Studyauditory cueingcognitioncortexfNIRSwalkingBackground. Aging is associated with declining mobility, which negatively affects quality of life and incurs substantial economic costs. Techniques to maintain safe mobility in older adults are therefore essential. Rhythmic auditory cueing (RAC) can improve walking patterns in older adults. However, the neural correlates associated with RAC, how they are influenced by repeated exposure and their relationships with gait response, cognitive function, and depressive symptoms are unclear. Objectives. This study aimed to investigate the effects of RAC during walking on cortical activation and the relationship between RAC-related cortical changes and cognitive function, depressive symptoms, and gait response. Methods. Seventeen young adults and eighteen older adults walked on a motorized treadmill for 5 minutes (5 trials with alternating 30-second blocks of usual walking and RAC walking). Changes in oxygenated hemoglobin (HbO 2 ) in the frontal cortex were recorded using functional near-infrared spectroscopy. Cognitive domains were assessed through validated tests. A triaxial accelerometer measured gait parameters. Results. Gait variability decreased and prefrontal HbO 2 levels increased during cued walking relative to usual walking. Older adults showed greater HbO 2 levels in multiple motor regions during cued walking although the response reduced with repeated exposure. In older adults, lower depression scores, higher cognitive functioning, and reduced gait variability were linked with increased HbO 2 levels during RAC walking. Conclusion. These findings suggest that walking improves with RAC in older adults and is achieved through increased activity in multiple cortical areas. The cortical response decline with repeated exposure indicates older adults’ ability to adapt to a new task.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)National Institute for Health ResearchInstitute of Neuroscience Newcastle University Institute of AgeingSao Paulo State University (UNESP) Institute of Biosciences, Campus Rio ClaroThe Newcastle upon Tyne NHS Foundation TrustSao Paulo State University (UNESP) Institute of Biosciences, Campus Rio ClaroFAPESP: 2016/22750-0Newcastle University Institute of AgeingUniversidade Estadual Paulista (Unesp)The Newcastle upon Tyne NHS Foundation TrustVitorio, Rodrigo [UNESP]Stuart, SamuelGobbi, Lilian T. B. [UNESP]Rochester, LynnAlcock, LisaPantall, Annette2019-10-06T15:24:07Z2019-10-06T15:24:07Z2018-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article976-987http://dx.doi.org/10.1177/1545968318805159Neurorehabilitation and Neural Repair, v. 32, n. 11, p. 976-987, 2018.1552-68441545-9683http://hdl.handle.net/11449/18705610.1177/15459683188051592-s2.0-85056433592Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNeurorehabilitation and Neural Repairinfo:eu-repo/semantics/openAccess2021-10-23T16:36:51Zoai:repositorio.unesp.br:11449/187056Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:13:42.750278Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study |
title |
Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study |
spellingShingle |
Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study Vitorio, Rodrigo [UNESP] auditory cueing cognition cortex fNIRS walking |
title_short |
Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study |
title_full |
Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study |
title_fullStr |
Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study |
title_full_unstemmed |
Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study |
title_sort |
Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study |
author |
Vitorio, Rodrigo [UNESP] |
author_facet |
Vitorio, Rodrigo [UNESP] Stuart, Samuel Gobbi, Lilian T. B. [UNESP] Rochester, Lynn Alcock, Lisa Pantall, Annette |
author_role |
author |
author2 |
Stuart, Samuel Gobbi, Lilian T. B. [UNESP] Rochester, Lynn Alcock, Lisa Pantall, Annette |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Newcastle University Institute of Ageing Universidade Estadual Paulista (Unesp) The Newcastle upon Tyne NHS Foundation Trust |
dc.contributor.author.fl_str_mv |
Vitorio, Rodrigo [UNESP] Stuart, Samuel Gobbi, Lilian T. B. [UNESP] Rochester, Lynn Alcock, Lisa Pantall, Annette |
dc.subject.por.fl_str_mv |
auditory cueing cognition cortex fNIRS walking |
topic |
auditory cueing cognition cortex fNIRS walking |
description |
Background. Aging is associated with declining mobility, which negatively affects quality of life and incurs substantial economic costs. Techniques to maintain safe mobility in older adults are therefore essential. Rhythmic auditory cueing (RAC) can improve walking patterns in older adults. However, the neural correlates associated with RAC, how they are influenced by repeated exposure and their relationships with gait response, cognitive function, and depressive symptoms are unclear. Objectives. This study aimed to investigate the effects of RAC during walking on cortical activation and the relationship between RAC-related cortical changes and cognitive function, depressive symptoms, and gait response. Methods. Seventeen young adults and eighteen older adults walked on a motorized treadmill for 5 minutes (5 trials with alternating 30-second blocks of usual walking and RAC walking). Changes in oxygenated hemoglobin (HbO 2 ) in the frontal cortex were recorded using functional near-infrared spectroscopy. Cognitive domains were assessed through validated tests. A triaxial accelerometer measured gait parameters. Results. Gait variability decreased and prefrontal HbO 2 levels increased during cued walking relative to usual walking. Older adults showed greater HbO 2 levels in multiple motor regions during cued walking although the response reduced with repeated exposure. In older adults, lower depression scores, higher cognitive functioning, and reduced gait variability were linked with increased HbO 2 levels during RAC walking. Conclusion. These findings suggest that walking improves with RAC in older adults and is achieved through increased activity in multiple cortical areas. The cortical response decline with repeated exposure indicates older adults’ ability to adapt to a new task. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-01 2019-10-06T15:24:07Z 2019-10-06T15:24:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1177/1545968318805159 Neurorehabilitation and Neural Repair, v. 32, n. 11, p. 976-987, 2018. 1552-6844 1545-9683 http://hdl.handle.net/11449/187056 10.1177/1545968318805159 2-s2.0-85056433592 |
url |
http://dx.doi.org/10.1177/1545968318805159 http://hdl.handle.net/11449/187056 |
identifier_str_mv |
Neurorehabilitation and Neural Repair, v. 32, n. 11, p. 976-987, 2018. 1552-6844 1545-9683 10.1177/1545968318805159 2-s2.0-85056433592 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neurorehabilitation and Neural Repair |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
976-987 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129176059772928 |