Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study

Detalhes bibliográficos
Autor(a) principal: Vitorio, Rodrigo [UNESP]
Data de Publicação: 2018
Outros Autores: Stuart, Samuel, Gobbi, Lilian T. B. [UNESP], Rochester, Lynn, Alcock, Lisa, Pantall, Annette
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1177/1545968318805159
http://hdl.handle.net/11449/187056
Resumo: Background. Aging is associated with declining mobility, which negatively affects quality of life and incurs substantial economic costs. Techniques to maintain safe mobility in older adults are therefore essential. Rhythmic auditory cueing (RAC) can improve walking patterns in older adults. However, the neural correlates associated with RAC, how they are influenced by repeated exposure and their relationships with gait response, cognitive function, and depressive symptoms are unclear. Objectives. This study aimed to investigate the effects of RAC during walking on cortical activation and the relationship between RAC-related cortical changes and cognitive function, depressive symptoms, and gait response. Methods. Seventeen young adults and eighteen older adults walked on a motorized treadmill for 5 minutes (5 trials with alternating 30-second blocks of usual walking and RAC walking). Changes in oxygenated hemoglobin (HbO 2 ) in the frontal cortex were recorded using functional near-infrared spectroscopy. Cognitive domains were assessed through validated tests. A triaxial accelerometer measured gait parameters. Results. Gait variability decreased and prefrontal HbO 2 levels increased during cued walking relative to usual walking. Older adults showed greater HbO 2 levels in multiple motor regions during cued walking although the response reduced with repeated exposure. In older adults, lower depression scores, higher cognitive functioning, and reduced gait variability were linked with increased HbO 2 levels during RAC walking. Conclusion. These findings suggest that walking improves with RAC in older adults and is achieved through increased activity in multiple cortical areas. The cortical response decline with repeated exposure indicates older adults’ ability to adapt to a new task.
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spelling Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Studyauditory cueingcognitioncortexfNIRSwalkingBackground. Aging is associated with declining mobility, which negatively affects quality of life and incurs substantial economic costs. Techniques to maintain safe mobility in older adults are therefore essential. Rhythmic auditory cueing (RAC) can improve walking patterns in older adults. However, the neural correlates associated with RAC, how they are influenced by repeated exposure and their relationships with gait response, cognitive function, and depressive symptoms are unclear. Objectives. This study aimed to investigate the effects of RAC during walking on cortical activation and the relationship between RAC-related cortical changes and cognitive function, depressive symptoms, and gait response. Methods. Seventeen young adults and eighteen older adults walked on a motorized treadmill for 5 minutes (5 trials with alternating 30-second blocks of usual walking and RAC walking). Changes in oxygenated hemoglobin (HbO 2 ) in the frontal cortex were recorded using functional near-infrared spectroscopy. Cognitive domains were assessed through validated tests. A triaxial accelerometer measured gait parameters. Results. Gait variability decreased and prefrontal HbO 2 levels increased during cued walking relative to usual walking. Older adults showed greater HbO 2 levels in multiple motor regions during cued walking although the response reduced with repeated exposure. In older adults, lower depression scores, higher cognitive functioning, and reduced gait variability were linked with increased HbO 2 levels during RAC walking. Conclusion. These findings suggest that walking improves with RAC in older adults and is achieved through increased activity in multiple cortical areas. The cortical response decline with repeated exposure indicates older adults’ ability to adapt to a new task.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)National Institute for Health ResearchInstitute of Neuroscience Newcastle University Institute of AgeingSao Paulo State University (UNESP) Institute of Biosciences, Campus Rio ClaroThe Newcastle upon Tyne NHS Foundation TrustSao Paulo State University (UNESP) Institute of Biosciences, Campus Rio ClaroFAPESP: 2016/22750-0Newcastle University Institute of AgeingUniversidade Estadual Paulista (Unesp)The Newcastle upon Tyne NHS Foundation TrustVitorio, Rodrigo [UNESP]Stuart, SamuelGobbi, Lilian T. B. [UNESP]Rochester, LynnAlcock, LisaPantall, Annette2019-10-06T15:24:07Z2019-10-06T15:24:07Z2018-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article976-987http://dx.doi.org/10.1177/1545968318805159Neurorehabilitation and Neural Repair, v. 32, n. 11, p. 976-987, 2018.1552-68441545-9683http://hdl.handle.net/11449/18705610.1177/15459683188051592-s2.0-85056433592Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNeurorehabilitation and Neural Repairinfo:eu-repo/semantics/openAccess2021-10-23T16:36:51Zoai:repositorio.unesp.br:11449/187056Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:13:42.750278Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study
title Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study
spellingShingle Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study
Vitorio, Rodrigo [UNESP]
auditory cueing
cognition
cortex
fNIRS
walking
title_short Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study
title_full Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study
title_fullStr Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study
title_full_unstemmed Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study
title_sort Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study
author Vitorio, Rodrigo [UNESP]
author_facet Vitorio, Rodrigo [UNESP]
Stuart, Samuel
Gobbi, Lilian T. B. [UNESP]
Rochester, Lynn
Alcock, Lisa
Pantall, Annette
author_role author
author2 Stuart, Samuel
Gobbi, Lilian T. B. [UNESP]
Rochester, Lynn
Alcock, Lisa
Pantall, Annette
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Newcastle University Institute of Ageing
Universidade Estadual Paulista (Unesp)
The Newcastle upon Tyne NHS Foundation Trust
dc.contributor.author.fl_str_mv Vitorio, Rodrigo [UNESP]
Stuart, Samuel
Gobbi, Lilian T. B. [UNESP]
Rochester, Lynn
Alcock, Lisa
Pantall, Annette
dc.subject.por.fl_str_mv auditory cueing
cognition
cortex
fNIRS
walking
topic auditory cueing
cognition
cortex
fNIRS
walking
description Background. Aging is associated with declining mobility, which negatively affects quality of life and incurs substantial economic costs. Techniques to maintain safe mobility in older adults are therefore essential. Rhythmic auditory cueing (RAC) can improve walking patterns in older adults. However, the neural correlates associated with RAC, how they are influenced by repeated exposure and their relationships with gait response, cognitive function, and depressive symptoms are unclear. Objectives. This study aimed to investigate the effects of RAC during walking on cortical activation and the relationship between RAC-related cortical changes and cognitive function, depressive symptoms, and gait response. Methods. Seventeen young adults and eighteen older adults walked on a motorized treadmill for 5 minutes (5 trials with alternating 30-second blocks of usual walking and RAC walking). Changes in oxygenated hemoglobin (HbO 2 ) in the frontal cortex were recorded using functional near-infrared spectroscopy. Cognitive domains were assessed through validated tests. A triaxial accelerometer measured gait parameters. Results. Gait variability decreased and prefrontal HbO 2 levels increased during cued walking relative to usual walking. Older adults showed greater HbO 2 levels in multiple motor regions during cued walking although the response reduced with repeated exposure. In older adults, lower depression scores, higher cognitive functioning, and reduced gait variability were linked with increased HbO 2 levels during RAC walking. Conclusion. These findings suggest that walking improves with RAC in older adults and is achieved through increased activity in multiple cortical areas. The cortical response decline with repeated exposure indicates older adults’ ability to adapt to a new task.
publishDate 2018
dc.date.none.fl_str_mv 2018-11-01
2019-10-06T15:24:07Z
2019-10-06T15:24:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1177/1545968318805159
Neurorehabilitation and Neural Repair, v. 32, n. 11, p. 976-987, 2018.
1552-6844
1545-9683
http://hdl.handle.net/11449/187056
10.1177/1545968318805159
2-s2.0-85056433592
url http://dx.doi.org/10.1177/1545968318805159
http://hdl.handle.net/11449/187056
identifier_str_mv Neurorehabilitation and Neural Repair, v. 32, n. 11, p. 976-987, 2018.
1552-6844
1545-9683
10.1177/1545968318805159
2-s2.0-85056433592
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Neurorehabilitation and Neural Repair
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 976-987
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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