In vivo and in vitro models of hepatocellular carcinoma: Current strategies for translational modeling
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/cancers13215583 http://hdl.handle.net/11449/229839 |
Resumo: | Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer‐related death globally. HCC is a complex multistep disease and usually emerges in the setting of chronic liver diseases. The molecular pathogenesis of HCC varies according to the etiology, mainly caused by chronic hepatitis B and C virus infections, chronic alcohol consumption, aflatoxin‐contaminated food, and non‐alcoholic fatty liver disease associated with metabolic syndrome or diabetes mellitus. The establishment of HCC models has become essential for both basic and translational research to improve our understanding of the pathophysiology and unravel new molecular drivers of this disease. The ideal model should recapitulate key events observed during hepatocarcinogenesis and HCC progression in view of establishing effective diagnostic and therapeutic strategies to be translated into clinical practice. Despite considerable efforts currently devoted to liver cancer research, only a few anti‐HCC drugs are available, and patient prognosis and survival are still poor. The present paper provides a state-of‐the‐art overview of in vivo and in vitro models used for translational modeling of HCC with a specific focus on their key molecular hallmarks. |
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In vivo and in vitro models of hepatocellular carcinoma: Current strategies for translational modelingAnimal modelCell cultureEpigenetic alterationGene mutationHepatocarcinogenesisLiver cancerTranslational researchHepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer‐related death globally. HCC is a complex multistep disease and usually emerges in the setting of chronic liver diseases. The molecular pathogenesis of HCC varies according to the etiology, mainly caused by chronic hepatitis B and C virus infections, chronic alcohol consumption, aflatoxin‐contaminated food, and non‐alcoholic fatty liver disease associated with metabolic syndrome or diabetes mellitus. The establishment of HCC models has become essential for both basic and translational research to improve our understanding of the pathophysiology and unravel new molecular drivers of this disease. The ideal model should recapitulate key events observed during hepatocarcinogenesis and HCC progression in view of establishing effective diagnostic and therapeutic strategies to be translated into clinical practice. Despite considerable efforts currently devoted to liver cancer research, only a few anti‐HCC drugs are available, and patient prognosis and survival are still poor. The present paper provides a state-of‐the‐art overview of in vivo and in vitro models used for translational modeling of HCC with a specific focus on their key molecular hallmarks.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fonds Wetenschappelijk OnderzoekConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Pathology School of Veterinary Medicine and Animal Science University of São Paulo (USP)Department of Structural and Functional Biology Biosciences Institute São Paulo State University (UNESP)Department of Pathology Botucatu Medical School São Paulo State University (UNESP)Department of Pharmaceutical and Pharmacological Sciences Vrije Universiteit BrusselGut‐Liver Immunopharmacology Unit Basic and Applied Medical Sciences Liver Research Center Ghent Faculty of Medicine and Health Sciences Ghent UniversityHepatology Research Unit Internal Medicine and Paediatrics Liver Research Center Ghent Faculty of Medicine and Health Sciences Ghent UniversityDepartment of Gastroenterology Clinics Hospital School of Medicine University of São Paulo (HC‐FMUSP)Department of Immunology Institute of Biomedical Sciences IV University of São Paulo (USP)Department of Structural and Functional Biology Biosciences Institute São Paulo State University (UNESP)Department of Pathology Botucatu Medical School São Paulo State University (UNESP)CAPES: 001FAPESP: 16/12015‐0FAPESP: 16/14420‐0FAPESP: 18/10953‐9Fonds Wetenschappelijk Onderzoek: 18/10953‐9CNPq: 310557/2019‐4Fonds Wetenschappelijk Onderzoek: G009514NFonds Wetenschappelijk Onderzoek: G010214NUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Vrije Universiteit BrusselGhent UniversityRomualdo, Guilherme Ribeiro [UNESP]Leroy, KaatCosta, Cícero Júlio SilvaPrata, Gabriel Bacil [UNESP]Vanderborght, Bartda Silva, Tereza CristinaBarbisan, Luís Fernando [UNESP]Andraus, WellingtonDevisscher, LindseyCâmara, Niels Olsen SaraivaVinken, MathieuCogliati, Bruno2022-04-29T08:36:12Z2022-04-29T08:36:12Z2021-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/cancers13215583Cancers, v. 13, n. 21, 2021.2072-6694http://hdl.handle.net/11449/22983910.3390/cancers132155832-s2.0-85118497624Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCancersinfo:eu-repo/semantics/openAccess2024-09-03T13:15:14Zoai:repositorio.unesp.br:11449/229839Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In vivo and in vitro models of hepatocellular carcinoma: Current strategies for translational modeling |
title |
In vivo and in vitro models of hepatocellular carcinoma: Current strategies for translational modeling |
spellingShingle |
In vivo and in vitro models of hepatocellular carcinoma: Current strategies for translational modeling Romualdo, Guilherme Ribeiro [UNESP] Animal model Cell culture Epigenetic alteration Gene mutation Hepatocarcinogenesis Liver cancer Translational research |
title_short |
In vivo and in vitro models of hepatocellular carcinoma: Current strategies for translational modeling |
title_full |
In vivo and in vitro models of hepatocellular carcinoma: Current strategies for translational modeling |
title_fullStr |
In vivo and in vitro models of hepatocellular carcinoma: Current strategies for translational modeling |
title_full_unstemmed |
In vivo and in vitro models of hepatocellular carcinoma: Current strategies for translational modeling |
title_sort |
In vivo and in vitro models of hepatocellular carcinoma: Current strategies for translational modeling |
author |
Romualdo, Guilherme Ribeiro [UNESP] |
author_facet |
Romualdo, Guilherme Ribeiro [UNESP] Leroy, Kaat Costa, Cícero Júlio Silva Prata, Gabriel Bacil [UNESP] Vanderborght, Bart da Silva, Tereza Cristina Barbisan, Luís Fernando [UNESP] Andraus, Wellington Devisscher, Lindsey Câmara, Niels Olsen Saraiva Vinken, Mathieu Cogliati, Bruno |
author_role |
author |
author2 |
Leroy, Kaat Costa, Cícero Júlio Silva Prata, Gabriel Bacil [UNESP] Vanderborght, Bart da Silva, Tereza Cristina Barbisan, Luís Fernando [UNESP] Andraus, Wellington Devisscher, Lindsey Câmara, Niels Olsen Saraiva Vinken, Mathieu Cogliati, Bruno |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) Vrije Universiteit Brussel Ghent University |
dc.contributor.author.fl_str_mv |
Romualdo, Guilherme Ribeiro [UNESP] Leroy, Kaat Costa, Cícero Júlio Silva Prata, Gabriel Bacil [UNESP] Vanderborght, Bart da Silva, Tereza Cristina Barbisan, Luís Fernando [UNESP] Andraus, Wellington Devisscher, Lindsey Câmara, Niels Olsen Saraiva Vinken, Mathieu Cogliati, Bruno |
dc.subject.por.fl_str_mv |
Animal model Cell culture Epigenetic alteration Gene mutation Hepatocarcinogenesis Liver cancer Translational research |
topic |
Animal model Cell culture Epigenetic alteration Gene mutation Hepatocarcinogenesis Liver cancer Translational research |
description |
Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer‐related death globally. HCC is a complex multistep disease and usually emerges in the setting of chronic liver diseases. The molecular pathogenesis of HCC varies according to the etiology, mainly caused by chronic hepatitis B and C virus infections, chronic alcohol consumption, aflatoxin‐contaminated food, and non‐alcoholic fatty liver disease associated with metabolic syndrome or diabetes mellitus. The establishment of HCC models has become essential for both basic and translational research to improve our understanding of the pathophysiology and unravel new molecular drivers of this disease. The ideal model should recapitulate key events observed during hepatocarcinogenesis and HCC progression in view of establishing effective diagnostic and therapeutic strategies to be translated into clinical practice. Despite considerable efforts currently devoted to liver cancer research, only a few anti‐HCC drugs are available, and patient prognosis and survival are still poor. The present paper provides a state-of‐the‐art overview of in vivo and in vitro models used for translational modeling of HCC with a specific focus on their key molecular hallmarks. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-01 2022-04-29T08:36:12Z 2022-04-29T08:36:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/cancers13215583 Cancers, v. 13, n. 21, 2021. 2072-6694 http://hdl.handle.net/11449/229839 10.3390/cancers13215583 2-s2.0-85118497624 |
url |
http://dx.doi.org/10.3390/cancers13215583 http://hdl.handle.net/11449/229839 |
identifier_str_mv |
Cancers, v. 13, n. 21, 2021. 2072-6694 10.3390/cancers13215583 2-s2.0-85118497624 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cancers |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021384167882752 |