Resistant starch/pectin free-standing films reinforced with nanocellulose intended for colonic methotrexate release

Detalhes bibliográficos
Autor(a) principal: Meneguin, Andréia B.
Data de Publicação: 2017
Outros Autores: Ferreira Cury, Beatriz Stringhetti [UNESP], dos Santos, Aline M. [UNESP], Franco, Douglas Faza [UNESP], Barud, Hernane S. [UNESP], da Silva Filho, Edson C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.carbpol.2016.10.062
http://hdl.handle.net/11449/173909
Resumo: Although resistant starch/pectin (RS/P) films have previously displayed suitable properties for colon-specific drug delivery, nanocomposite films were developed aiming to enhance physicochemical, thermal, mechanical and barrier properties, as well as the low oral bioavailability of methotrexate (MTX). FEG-SEM micrographs of nanocomposite films showed different interaction patterns occurring among nanocellulose and RS/P. The nanofiller addition led to an increase in the thermal stability, probably due to its interaction with RS crystalline double helices. Results also displayed an improvement of the puncture strength, while barrier properties revealed a low water vapor permeability. Ex vivo bioadhesion test displayed the nanocomposites films to interact strongly with porcine gastrointestinal mucosa. In vitro drug release studies showed that the films developed enhanced the drug dissolution rates with approximately 80% of MTX release in 150 min, suggesting the potential of these materials as a poor solubility drugs carrier, which constitutes an important tool for enhancing oral bioavailability.
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spelling Resistant starch/pectin free-standing films reinforced with nanocellulose intended for colonic methotrexate releaseCellulose nanofiberFree-standing filmsMethotrexateNanocellulosePectinResistant starchAlthough resistant starch/pectin (RS/P) films have previously displayed suitable properties for colon-specific drug delivery, nanocomposite films were developed aiming to enhance physicochemical, thermal, mechanical and barrier properties, as well as the low oral bioavailability of methotrexate (MTX). FEG-SEM micrographs of nanocomposite films showed different interaction patterns occurring among nanocellulose and RS/P. The nanofiller addition led to an increase in the thermal stability, probably due to its interaction with RS crystalline double helices. Results also displayed an improvement of the puncture strength, while barrier properties revealed a low water vapor permeability. Ex vivo bioadhesion test displayed the nanocomposites films to interact strongly with porcine gastrointestinal mucosa. In vitro drug release studies showed that the films developed enhanced the drug dissolution rates with approximately 80% of MTX release in 150 min, suggesting the potential of these materials as a poor solubility drugs carrier, which constitutes an important tool for enhancing oral bioavailability.Interdisciplinary Laboratory of Advanced Materials Centro de Ciências da Natureza – CNN Universidade Federal do Piauí – UFPIDepartment of Drugs and Pharmaceuticals Faculty of Pharmaceutical Sciences São Paulo State University-UNESPInstitute of Chemistry São Paulo State University – UNESPUniversidade de Araraquara – UNIARADepartment of Drugs and Pharmaceuticals Faculty of Pharmaceutical Sciences São Paulo State University-UNESPInstitute of Chemistry São Paulo State University – UNESPUniversidade Federal do Piauí – UFPIUniversidade Estadual Paulista (Unesp)Universidade de Araraquara – UNIARAMeneguin, Andréia B.Ferreira Cury, Beatriz Stringhetti [UNESP]dos Santos, Aline M. [UNESP]Franco, Douglas Faza [UNESP]Barud, Hernane S. [UNESP]da Silva Filho, Edson C.2018-12-11T17:08:18Z2018-12-11T17:08:18Z2017-02-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1013-1023application/pdfhttp://dx.doi.org/10.1016/j.carbpol.2016.10.062Carbohydrate Polymers, v. 157, p. 1013-1023.0144-8617http://hdl.handle.net/11449/17390910.1016/j.carbpol.2016.10.0622-s2.0-850059503422-s2.0-85005950342.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCarbohydrate Polymers1,428info:eu-repo/semantics/openAccess2024-06-24T13:44:48Zoai:repositorio.unesp.br:11449/173909Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:31:44.333028Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Resistant starch/pectin free-standing films reinforced with nanocellulose intended for colonic methotrexate release
title Resistant starch/pectin free-standing films reinforced with nanocellulose intended for colonic methotrexate release
spellingShingle Resistant starch/pectin free-standing films reinforced with nanocellulose intended for colonic methotrexate release
Meneguin, Andréia B.
Cellulose nanofiber
Free-standing films
Methotrexate
Nanocellulose
Pectin
Resistant starch
title_short Resistant starch/pectin free-standing films reinforced with nanocellulose intended for colonic methotrexate release
title_full Resistant starch/pectin free-standing films reinforced with nanocellulose intended for colonic methotrexate release
title_fullStr Resistant starch/pectin free-standing films reinforced with nanocellulose intended for colonic methotrexate release
title_full_unstemmed Resistant starch/pectin free-standing films reinforced with nanocellulose intended for colonic methotrexate release
title_sort Resistant starch/pectin free-standing films reinforced with nanocellulose intended for colonic methotrexate release
author Meneguin, Andréia B.
author_facet Meneguin, Andréia B.
Ferreira Cury, Beatriz Stringhetti [UNESP]
dos Santos, Aline M. [UNESP]
Franco, Douglas Faza [UNESP]
Barud, Hernane S. [UNESP]
da Silva Filho, Edson C.
author_role author
author2 Ferreira Cury, Beatriz Stringhetti [UNESP]
dos Santos, Aline M. [UNESP]
Franco, Douglas Faza [UNESP]
Barud, Hernane S. [UNESP]
da Silva Filho, Edson C.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do Piauí – UFPI
Universidade Estadual Paulista (Unesp)
Universidade de Araraquara – UNIARA
dc.contributor.author.fl_str_mv Meneguin, Andréia B.
Ferreira Cury, Beatriz Stringhetti [UNESP]
dos Santos, Aline M. [UNESP]
Franco, Douglas Faza [UNESP]
Barud, Hernane S. [UNESP]
da Silva Filho, Edson C.
dc.subject.por.fl_str_mv Cellulose nanofiber
Free-standing films
Methotrexate
Nanocellulose
Pectin
Resistant starch
topic Cellulose nanofiber
Free-standing films
Methotrexate
Nanocellulose
Pectin
Resistant starch
description Although resistant starch/pectin (RS/P) films have previously displayed suitable properties for colon-specific drug delivery, nanocomposite films were developed aiming to enhance physicochemical, thermal, mechanical and barrier properties, as well as the low oral bioavailability of methotrexate (MTX). FEG-SEM micrographs of nanocomposite films showed different interaction patterns occurring among nanocellulose and RS/P. The nanofiller addition led to an increase in the thermal stability, probably due to its interaction with RS crystalline double helices. Results also displayed an improvement of the puncture strength, while barrier properties revealed a low water vapor permeability. Ex vivo bioadhesion test displayed the nanocomposites films to interact strongly with porcine gastrointestinal mucosa. In vitro drug release studies showed that the films developed enhanced the drug dissolution rates with approximately 80% of MTX release in 150 min, suggesting the potential of these materials as a poor solubility drugs carrier, which constitutes an important tool for enhancing oral bioavailability.
publishDate 2017
dc.date.none.fl_str_mv 2017-02-10
2018-12-11T17:08:18Z
2018-12-11T17:08:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.carbpol.2016.10.062
Carbohydrate Polymers, v. 157, p. 1013-1023.
0144-8617
http://hdl.handle.net/11449/173909
10.1016/j.carbpol.2016.10.062
2-s2.0-85005950342
2-s2.0-85005950342.pdf
url http://dx.doi.org/10.1016/j.carbpol.2016.10.062
http://hdl.handle.net/11449/173909
identifier_str_mv Carbohydrate Polymers, v. 157, p. 1013-1023.
0144-8617
10.1016/j.carbpol.2016.10.062
2-s2.0-85005950342
2-s2.0-85005950342.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Carbohydrate Polymers
1,428
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1013-1023
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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