Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| DOI: | 10.1590/1678-7757-2018-0574 |
| Texto Completo: | http://dx.doi.org/10.1590/1678-7757-2018-0574 http://hdl.handle.net/11449/213095 |
Resumo: | Hypertension is one of the main causes of premature death in the world; also, it is associated with several bone alterations. Preclinical studies have demonstrated delayed alveolar bone healing in hypertensive rats. However, losartan has been favorable for consolidation of bone grafts and reduction in active periodontitis. Therefore, losartan is suggested to be effective in bone formation stages, as well as in the synthesis of matrix proteins and mineralization. |
| id |
UNSP_2e6d449c574f7cfb54273e63840b34c4 |
|---|---|
| oai_identifier_str |
oai:repositorio.unesp.br:11449/213095 |
| network_acronym_str |
UNSP |
| network_name_str |
Repositório Institucional da UNESP |
| repository_id_str |
2946 |
| spelling |
Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive ratsLosartanSpontaneously hypertensive ratsBoneHypertensionHypertension is one of the main causes of premature death in the world; also, it is associated with several bone alterations. Preclinical studies have demonstrated delayed alveolar bone healing in hypertensive rats. However, losartan has been favorable for consolidation of bone grafts and reduction in active periodontitis. Therefore, losartan is suggested to be effective in bone formation stages, as well as in the synthesis of matrix proteins and mineralization.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista, Faculdade de Odontologia de AraçatubaUniversidade Estadual Paulista, Faculdade de odontologia de AraçatubaUniversidade Estadual Paulista, Faculdade de Odontologia de AraçatubaUniversidade Estadual Paulista, Faculdade de odontologia de AraçatubaFAPESP: 2016/03245-2; 2017/23082-3; 2017/16912-0Faculdade De Odontologia De Bauru - USPUniversidade Estadual Paulista (Unesp)Mulinari-santos, Gabriel [UNESP]Santos, Jaqueline Silva Dos [UNESP]Palin, Letícia Pitol [UNESP]Silva, Ana Cláudia Ervolino Da [UNESP]Antoniali, Cristina [UNESP]Faverani, Leonardo Perez [UNESP]Okamoto, Roberta [UNESP]2021-07-14T10:49:57Z2021-07-14T10:49:57Z2019-10-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article-application/pdfhttp://dx.doi.org/10.1590/1678-7757-2018-0574Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 27, p. -, 2019.1678-77571678-7765http://hdl.handle.net/11449/21309510.1590/1678-7757-2018-0574S1678-77572019000100479S1678-77572019000100479.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Oral Scienceinfo:eu-repo/semantics/openAccess2024-09-19T14:03:05Zoai:repositorio.unesp.br:11449/213095Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T14:03:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats |
| title |
Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats |
| spellingShingle |
Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats Mulinari-santos, Gabriel [UNESP] Losartan Spontaneously hypertensive rats Bone Hypertension Mulinari-santos, Gabriel [UNESP] Losartan Spontaneously hypertensive rats Bone Hypertension |
| title_short |
Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats |
| title_full |
Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats |
| title_fullStr |
Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats |
| title_full_unstemmed |
Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats |
| title_sort |
Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats |
| author |
Mulinari-santos, Gabriel [UNESP] |
| author_facet |
Mulinari-santos, Gabriel [UNESP] Mulinari-santos, Gabriel [UNESP] Santos, Jaqueline Silva Dos [UNESP] Palin, Letícia Pitol [UNESP] Silva, Ana Cláudia Ervolino Da [UNESP] Antoniali, Cristina [UNESP] Faverani, Leonardo Perez [UNESP] Okamoto, Roberta [UNESP] Santos, Jaqueline Silva Dos [UNESP] Palin, Letícia Pitol [UNESP] Silva, Ana Cláudia Ervolino Da [UNESP] Antoniali, Cristina [UNESP] Faverani, Leonardo Perez [UNESP] Okamoto, Roberta [UNESP] |
| author_role |
author |
| author2 |
Santos, Jaqueline Silva Dos [UNESP] Palin, Letícia Pitol [UNESP] Silva, Ana Cláudia Ervolino Da [UNESP] Antoniali, Cristina [UNESP] Faverani, Leonardo Perez [UNESP] Okamoto, Roberta [UNESP] |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
| dc.contributor.author.fl_str_mv |
Mulinari-santos, Gabriel [UNESP] Santos, Jaqueline Silva Dos [UNESP] Palin, Letícia Pitol [UNESP] Silva, Ana Cláudia Ervolino Da [UNESP] Antoniali, Cristina [UNESP] Faverani, Leonardo Perez [UNESP] Okamoto, Roberta [UNESP] |
| dc.subject.por.fl_str_mv |
Losartan Spontaneously hypertensive rats Bone Hypertension |
| topic |
Losartan Spontaneously hypertensive rats Bone Hypertension |
| description |
Hypertension is one of the main causes of premature death in the world; also, it is associated with several bone alterations. Preclinical studies have demonstrated delayed alveolar bone healing in hypertensive rats. However, losartan has been favorable for consolidation of bone grafts and reduction in active periodontitis. Therefore, losartan is suggested to be effective in bone formation stages, as well as in the synthesis of matrix proteins and mineralization. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-10-07 2021-07-14T10:49:57Z 2021-07-14T10:49:57Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-7757-2018-0574 Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 27, p. -, 2019. 1678-7757 1678-7765 http://hdl.handle.net/11449/213095 10.1590/1678-7757-2018-0574 S1678-77572019000100479 S1678-77572019000100479.pdf |
| url |
http://dx.doi.org/10.1590/1678-7757-2018-0574 http://hdl.handle.net/11449/213095 |
| identifier_str_mv |
Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 27, p. -, 2019. 1678-7757 1678-7765 10.1590/1678-7757-2018-0574 S1678-77572019000100479 S1678-77572019000100479.pdf |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Journal of Applied Oral Science |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
- application/pdf |
| dc.publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
| publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
| dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
| instname_str |
Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
| institution |
UNESP |
| reponame_str |
Repositório Institucional da UNESP |
| collection |
Repositório Institucional da UNESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
| repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
| _version_ |
1822179109857394688 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/1678-7757-2018-0574 |