Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng spa |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4067/S0717-95022013000400017 http://hdl.handle.net/11449/220083 |
Resumo: | We evaluated the sperm parameters such as cauda epididymis weight, sperm count, sperm morphology and sperm DNA stability of adult CF-1 male mice treated daily (oral exposure) with the toxic sodium arsenite (As, 7.0 mg/kg/body weight); Melatonin (Me, 10.0 mg/kg/bw), Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw) and Negative Control (NaCl 0.9%) to assess acute (8.3 days), chronic (33.2 days) and recovery of testicular damage (66.4 days). Arsenic decreases the number of sperm from chronic treatment (33.2 days) and this effect continued until 66.4 days of treatment. The toxic effect of As also altered the morphology of spermatozoa in all treatment periods when compared to the negative control group. However, Metalonin induced protective effects in periods of 33.2 and 66.4 days of treatment. Additionally, the stability of DNA was significantly affected by arsenic in all periods, but the chronic treatment (33.2 days) in the AsMe revealed increased stability compared to the group treated with arsenic only. Melatonin partially protects sperm toxicity caused by Arsenic, especially during periods of 33.2 and 66.4 days. |
id |
UNSP_2e8c38d35c967aa84fad382dd43c96b9 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/220083 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodioMelatonin protective role in mouse cauda epipidymal spermatozoa damage induced by sodium arseniteArsenicDNA stabilityMelatoninMouseSpermWe evaluated the sperm parameters such as cauda epididymis weight, sperm count, sperm morphology and sperm DNA stability of adult CF-1 male mice treated daily (oral exposure) with the toxic sodium arsenite (As, 7.0 mg/kg/body weight); Melatonin (Me, 10.0 mg/kg/bw), Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw) and Negative Control (NaCl 0.9%) to assess acute (8.3 days), chronic (33.2 days) and recovery of testicular damage (66.4 days). Arsenic decreases the number of sperm from chronic treatment (33.2 days) and this effect continued until 66.4 days of treatment. The toxic effect of As also altered the morphology of spermatozoa in all treatment periods when compared to the negative control group. However, Metalonin induced protective effects in periods of 33.2 and 66.4 days of treatment. Additionally, the stability of DNA was significantly affected by arsenic in all periods, but the chronic treatment (33.2 days) in the AsMe revealed increased stability compared to the group treated with arsenic only. Melatonin partially protects sperm toxicity caused by Arsenic, especially during periods of 33.2 and 66.4 days.Universidad de La Frontera, TemucoUniversity of Chile Medical School, SantiagoVeterinary School Universidad Santo TomásCentro de Investigación en Ciencias Biomédicas Universidad Autónoma de Chile, TemucoSão Paulo State University, BotucatuSão Paulo State University, BotucatuUniversidad de La FronteraMedical SchoolUniversidad Santo TomásUniversidad Autónoma de ChileUniversidade Estadual Paulista (UNESP)Bustos-Obregón, EduardoPoblete, DanielCatriao, Robertodel Sol, MarianoFernandes, Fábio Henrique [UNESP]2022-04-28T18:59:27Z2022-04-28T18:59:27Z2013-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1251-1256http://dx.doi.org/10.4067/S0717-95022013000400017International Journal of Morphology, v. 31, n. 4, p. 1251-1256, 2013.0717-93670717-9502http://hdl.handle.net/11449/22008310.4067/S0717-950220130004000172-s2.0-84894276180Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengspaInternational Journal of Morphology229524info:eu-repo/semantics/openAccess2023-05-25T18:51:13Zoai:repositorio.unesp.br:11449/220083Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:11:19.374127Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio Melatonin protective role in mouse cauda epipidymal spermatozoa damage induced by sodium arsenite |
title |
Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio |
spellingShingle |
Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio Bustos-Obregón, Eduardo Arsenic DNA stability Melatonin Mouse Sperm |
title_short |
Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio |
title_full |
Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio |
title_fullStr |
Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio |
title_full_unstemmed |
Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio |
title_sort |
Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio |
author |
Bustos-Obregón, Eduardo |
author_facet |
Bustos-Obregón, Eduardo Poblete, Daniel Catriao, Roberto del Sol, Mariano Fernandes, Fábio Henrique [UNESP] |
author_role |
author |
author2 |
Poblete, Daniel Catriao, Roberto del Sol, Mariano Fernandes, Fábio Henrique [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidad de La Frontera Medical School Universidad Santo Tomás Universidad Autónoma de Chile Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Bustos-Obregón, Eduardo Poblete, Daniel Catriao, Roberto del Sol, Mariano Fernandes, Fábio Henrique [UNESP] |
dc.subject.por.fl_str_mv |
Arsenic DNA stability Melatonin Mouse Sperm |
topic |
Arsenic DNA stability Melatonin Mouse Sperm |
description |
We evaluated the sperm parameters such as cauda epididymis weight, sperm count, sperm morphology and sperm DNA stability of adult CF-1 male mice treated daily (oral exposure) with the toxic sodium arsenite (As, 7.0 mg/kg/body weight); Melatonin (Me, 10.0 mg/kg/bw), Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw) and Negative Control (NaCl 0.9%) to assess acute (8.3 days), chronic (33.2 days) and recovery of testicular damage (66.4 days). Arsenic decreases the number of sperm from chronic treatment (33.2 days) and this effect continued until 66.4 days of treatment. The toxic effect of As also altered the morphology of spermatozoa in all treatment periods when compared to the negative control group. However, Metalonin induced protective effects in periods of 33.2 and 66.4 days of treatment. Additionally, the stability of DNA was significantly affected by arsenic in all periods, but the chronic treatment (33.2 days) in the AsMe revealed increased stability compared to the group treated with arsenic only. Melatonin partially protects sperm toxicity caused by Arsenic, especially during periods of 33.2 and 66.4 days. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-01 2022-04-28T18:59:27Z 2022-04-28T18:59:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4067/S0717-95022013000400017 International Journal of Morphology, v. 31, n. 4, p. 1251-1256, 2013. 0717-9367 0717-9502 http://hdl.handle.net/11449/220083 10.4067/S0717-95022013000400017 2-s2.0-84894276180 |
url |
http://dx.doi.org/10.4067/S0717-95022013000400017 http://hdl.handle.net/11449/220083 |
identifier_str_mv |
International Journal of Morphology, v. 31, n. 4, p. 1251-1256, 2013. 0717-9367 0717-9502 10.4067/S0717-95022013000400017 2-s2.0-84894276180 |
dc.language.iso.fl_str_mv |
eng spa |
language |
eng spa |
dc.relation.none.fl_str_mv |
International Journal of Morphology 229524 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1251-1256 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128616124383232 |