Tandem Transesterification–Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation

• Autor(a) principal: Barbosa, Sandro L.
• Data de Publicação: 2022
• Outros Autores: Nelson, David Lee, Freitas, Milton de S., dos Santos, Wallans Torres Pio, Klein, Stanlei I. [UNESP], Clososki, Giuliano C., Caires, Franco J., Wentz, Alexandre P.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.3390/molecules27154767; http://hdl.handle.net/11449/241460
• topic: deacetylation (acyl nucleophilic substitution); green chemistry; methyl salicylate; methylating agent; solid acid catalyst; sulfonated silica catalyst (SiO2–SO3H)

SiO2–SO3H, with a surface area of 115 m2/g and pore volume of 0.38 cm3g−1, and 1.32 mmol H+/g was used as a 20% w/w catalyst for the preparation of methyl salicylate (wintergreen oil or MS) from acetylsalicylic acid (ASA). A 94% conversion was achieved in a microwave reactor over 40 min at 120 °C in MeOH. The resulting crude product was purified by flash chromatography. The catalyst could be reused three times.