Prognostic value of coupling interval, prematurity index and heart rate variability in Boxer dogs
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-5150-PVB-6264 http://hdl.handle.net/11449/201320 |
Resumo: | Boxer dogs with arrhythmogenic right ventricular cardiomyopathy (ARVC) can experience sudden cardiac death regardless of presence/absence of clinical signs. The aims of this retrospective study were two-fold: 1) to investigate the coupling interval (CI) and prematurity index (PI) of ventricular arrhythmias (VA), and the heart rate variability (HRV) in Boxers, and 2) to evaluate their impact on overall survival time. The first 24-hour Holter 36 client-owned Boxer dogs meeting inclusion/exclusion criteria were evaluated for the number, morphology, site of origin, complexity, CI and PI, of ventricular premature complexes (VPCs), and time domain HRV. The effect on survival was assessed, considering the presence/absence of ventricular tachycardia (VT), and syncope. All-cause mortality was considered as the end-point, with median survival times being obtained by Kaplan-Meier analyses and compared by log-rank test. Polymorphic VPCs were more common in symptomatic dogs than asymptomatic. VPCs in dogs with VT were less premature, due to the influence of heart rate on PI despite comparable CI. The PI and mean heart rate (HRme) were significantly different between VT and non-VT dogs but did not discriminate adequately between groups as standalone tests. Median survival time was shorter in Boxer dogs with VT (463 vs 1645 days, HR: 4.31, P=0.03). The HRV parameters, SDNN and SDANN, were both associated with prognosis. The CI and PI were not demonstrated to be prognostic surrogates in Boxer dogs with VA. HRme≥112bpm is 100% sensitive but only 46% specific for detecting VT in Boxers on the 24-hour Holter. Presence of VT, SDNN≤245ms, or SDANN≤134ms at the time of the first 24-hour Holter was associated with a shorter survival. |
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Prognostic value of coupling interval, prematurity index and heart rate variability in Boxer dogsArrhythmiasBoxer dogsCoupling intervalDogsHeart ratePrematurity indexPrognosticSudden deathSympathetic nervous systemBoxer dogs with arrhythmogenic right ventricular cardiomyopathy (ARVC) can experience sudden cardiac death regardless of presence/absence of clinical signs. The aims of this retrospective study were two-fold: 1) to investigate the coupling interval (CI) and prematurity index (PI) of ventricular arrhythmias (VA), and the heart rate variability (HRV) in Boxers, and 2) to evaluate their impact on overall survival time. The first 24-hour Holter 36 client-owned Boxer dogs meeting inclusion/exclusion criteria were evaluated for the number, morphology, site of origin, complexity, CI and PI, of ventricular premature complexes (VPCs), and time domain HRV. The effect on survival was assessed, considering the presence/absence of ventricular tachycardia (VT), and syncope. All-cause mortality was considered as the end-point, with median survival times being obtained by Kaplan-Meier analyses and compared by log-rank test. Polymorphic VPCs were more common in symptomatic dogs than asymptomatic. VPCs in dogs with VT were less premature, due to the influence of heart rate on PI despite comparable CI. The PI and mean heart rate (HRme) were significantly different between VT and non-VT dogs but did not discriminate adequately between groups as standalone tests. Median survival time was shorter in Boxer dogs with VT (463 vs 1645 days, HR: 4.31, P=0.03). The HRV parameters, SDNN and SDANN, were both associated with prognosis. The CI and PI were not demonstrated to be prognostic surrogates in Boxer dogs with VA. HRme≥112bpm is 100% sensitive but only 46% specific for detecting VT in Boxers on the 24-hour Holter. Presence of VT, SDNN≤245ms, or SDANN≤134ms at the time of the first 24-hour Holter was associated with a shorter survival.Faculdade de Medicina Veterinária e Ciências Agrárias Universidade Estadual Paulista (Unesp), Via de Acesso Prof. Paulo Donato Castellane s/nLaboratório de Cardiologia Comparativa Universidade Federal do Paraná (UFPR), Rua dos Funcionários 1540Faculdade de Medicina Veterinária e Ciências Agrárias Universidade Estadual Paulista (Unesp), Via de Acesso Prof. Paulo Donato Castellane s/nUniversidade Estadual Paulista (Unesp)Universidade Federal do Paraná (UFPR)Carvalho, Elizabeth Regina [UNESP]Zacché, Evandro [UNESP]Fenerich, Michelli [UNESP]Camacho, Aparecido Antônio [UNESP]Sousa, Marlos G.2020-12-12T02:29:36Z2020-12-12T02:29:36Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article635-642application/pdfhttp://dx.doi.org/10.1590/1678-5150-PVB-6264Pesquisa Veterinaria Brasileira, v. 39, n. 8, p. 635-642, 2019.1678-51500100-736Xhttp://hdl.handle.net/11449/20132010.1590/1678-5150-PVB-6264S0100-736X20190008006352-s2.0-85074861922S0100-736X2019000800635.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2024-06-06T14:09:24Zoai:repositorio.unesp.br:11449/201320Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:01:34.990973Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Prognostic value of coupling interval, prematurity index and heart rate variability in Boxer dogs |
title |
Prognostic value of coupling interval, prematurity index and heart rate variability in Boxer dogs |
spellingShingle |
Prognostic value of coupling interval, prematurity index and heart rate variability in Boxer dogs Carvalho, Elizabeth Regina [UNESP] Arrhythmias Boxer dogs Coupling interval Dogs Heart rate Prematurity index Prognostic Sudden death Sympathetic nervous system |
title_short |
Prognostic value of coupling interval, prematurity index and heart rate variability in Boxer dogs |
title_full |
Prognostic value of coupling interval, prematurity index and heart rate variability in Boxer dogs |
title_fullStr |
Prognostic value of coupling interval, prematurity index and heart rate variability in Boxer dogs |
title_full_unstemmed |
Prognostic value of coupling interval, prematurity index and heart rate variability in Boxer dogs |
title_sort |
Prognostic value of coupling interval, prematurity index and heart rate variability in Boxer dogs |
author |
Carvalho, Elizabeth Regina [UNESP] |
author_facet |
Carvalho, Elizabeth Regina [UNESP] Zacché, Evandro [UNESP] Fenerich, Michelli [UNESP] Camacho, Aparecido Antônio [UNESP] Sousa, Marlos G. |
author_role |
author |
author2 |
Zacché, Evandro [UNESP] Fenerich, Michelli [UNESP] Camacho, Aparecido Antônio [UNESP] Sousa, Marlos G. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal do Paraná (UFPR) |
dc.contributor.author.fl_str_mv |
Carvalho, Elizabeth Regina [UNESP] Zacché, Evandro [UNESP] Fenerich, Michelli [UNESP] Camacho, Aparecido Antônio [UNESP] Sousa, Marlos G. |
dc.subject.por.fl_str_mv |
Arrhythmias Boxer dogs Coupling interval Dogs Heart rate Prematurity index Prognostic Sudden death Sympathetic nervous system |
topic |
Arrhythmias Boxer dogs Coupling interval Dogs Heart rate Prematurity index Prognostic Sudden death Sympathetic nervous system |
description |
Boxer dogs with arrhythmogenic right ventricular cardiomyopathy (ARVC) can experience sudden cardiac death regardless of presence/absence of clinical signs. The aims of this retrospective study were two-fold: 1) to investigate the coupling interval (CI) and prematurity index (PI) of ventricular arrhythmias (VA), and the heart rate variability (HRV) in Boxers, and 2) to evaluate their impact on overall survival time. The first 24-hour Holter 36 client-owned Boxer dogs meeting inclusion/exclusion criteria were evaluated for the number, morphology, site of origin, complexity, CI and PI, of ventricular premature complexes (VPCs), and time domain HRV. The effect on survival was assessed, considering the presence/absence of ventricular tachycardia (VT), and syncope. All-cause mortality was considered as the end-point, with median survival times being obtained by Kaplan-Meier analyses and compared by log-rank test. Polymorphic VPCs were more common in symptomatic dogs than asymptomatic. VPCs in dogs with VT were less premature, due to the influence of heart rate on PI despite comparable CI. The PI and mean heart rate (HRme) were significantly different between VT and non-VT dogs but did not discriminate adequately between groups as standalone tests. Median survival time was shorter in Boxer dogs with VT (463 vs 1645 days, HR: 4.31, P=0.03). The HRV parameters, SDNN and SDANN, were both associated with prognosis. The CI and PI were not demonstrated to be prognostic surrogates in Boxer dogs with VA. HRme≥112bpm is 100% sensitive but only 46% specific for detecting VT in Boxers on the 24-hour Holter. Presence of VT, SDNN≤245ms, or SDANN≤134ms at the time of the first 24-hour Holter was associated with a shorter survival. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 2020-12-12T02:29:36Z 2020-12-12T02:29:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-5150-PVB-6264 Pesquisa Veterinaria Brasileira, v. 39, n. 8, p. 635-642, 2019. 1678-5150 0100-736X http://hdl.handle.net/11449/201320 10.1590/1678-5150-PVB-6264 S0100-736X2019000800635 2-s2.0-85074861922 S0100-736X2019000800635.pdf |
url |
http://dx.doi.org/10.1590/1678-5150-PVB-6264 http://hdl.handle.net/11449/201320 |
identifier_str_mv |
Pesquisa Veterinaria Brasileira, v. 39, n. 8, p. 635-642, 2019. 1678-5150 0100-736X 10.1590/1678-5150-PVB-6264 S0100-736X2019000800635 2-s2.0-85074861922 S0100-736X2019000800635.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pesquisa Veterinaria Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
635-642 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128595082608640 |