Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease

Detalhes bibliográficos
Autor(a) principal: Zanati, Silméia Garcia [UNESP]
Data de Publicação: 2009
Outros Autores: Mouraria, Guilherme Grisi [UNESP], Matsubara, Luiz Shiguero [UNESP], Giannini, Mariângela [UNESP], Matsubara, Beatriz Bojikian [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1807-59322009000400010
http://hdl.handle.net/11449/71094
Resumo: Introduction: The present study examines cardiovascular risk factor profiles and 24-month mortality in patients with symptomatic peripheral arterial disease. Design Study: Prospective observational study including 75 consecutive patients with PAD (67 ± 9.7 years of age; 52 men and 23 women) hospitalized for planned peripheral vascular reconstruction. Doppler echocardiograms were performed before surgery in 54 cases. Univariate analyses were performed using Student's t-test or Fisher's exact test. Survival analysis at 24-month follow-up was performed using the Cox regression model and Kaplan-Meier method including age and chronic use of aspirin as covariates. Survival curves were compared using the log-rank test. Results: Hypertension and smoking were the most frequent risk factors (52 cases and 51 cases, respectively), followed by diabetes (32 cases). Undertreated dyslipidemia was found in 26 cases. Fasting glycine levels (131 ± 69.1 mg/dl) were elevated in 29 cases. Myocardial hypertrophy was found in 18 out of 54 patients. Thirty-four patients had been treated with aspirin. Overall mortality over 24 months was 24% and was associated with age (HR: 0.064; CI95: 0.014-0.115; p=0.013) and lack of use of aspirin, as no deaths occurred among those using this drug (p<0.001). No association was found between cardiovascular death (11 cases) and the other risk factors. Conclusion: There is a high prevalence of uncontrolled (treated or untreated) cardiovascular risk factors in patients undergoing planned peripheral vascular reconstruction, and chronic use of aspirin is associated with reduced all-cause mortality in these patients.
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spelling Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial diseaseAspirinCardiovascular riskElderlySmokingVascular surgeryacetylsalicylic acidantithrombocytic agentagedBrazilcoronary artery diseasefemalehumanhypertensionKaplan Meier methodmalemortalityperipheral vascular diseaseprospective studyrisk factorsmokingsurvivalAgedCoronary Artery DiseaseFemaleHumansHypertensionKaplan-Meiers EstimateMalePeripheral Vascular DiseasesPlatelet Aggregation InhibitorsProspective StudiesRisk FactorsSurvival AnalysisIntroduction: The present study examines cardiovascular risk factor profiles and 24-month mortality in patients with symptomatic peripheral arterial disease. Design Study: Prospective observational study including 75 consecutive patients with PAD (67 ± 9.7 years of age; 52 men and 23 women) hospitalized for planned peripheral vascular reconstruction. Doppler echocardiograms were performed before surgery in 54 cases. Univariate analyses were performed using Student's t-test or Fisher's exact test. Survival analysis at 24-month follow-up was performed using the Cox regression model and Kaplan-Meier method including age and chronic use of aspirin as covariates. Survival curves were compared using the log-rank test. Results: Hypertension and smoking were the most frequent risk factors (52 cases and 51 cases, respectively), followed by diabetes (32 cases). Undertreated dyslipidemia was found in 26 cases. Fasting glycine levels (131 ± 69.1 mg/dl) were elevated in 29 cases. Myocardial hypertrophy was found in 18 out of 54 patients. Thirty-four patients had been treated with aspirin. Overall mortality over 24 months was 24% and was associated with age (HR: 0.064; CI95: 0.014-0.115; p=0.013) and lack of use of aspirin, as no deaths occurred among those using this drug (p<0.001). No association was found between cardiovascular death (11 cases) and the other risk factors. Conclusion: There is a high prevalence of uncontrolled (treated or untreated) cardiovascular risk factors in patients undergoing planned peripheral vascular reconstruction, and chronic use of aspirin is associated with reduced all-cause mortality in these patients.Department of Internal Medicine Botucatu Medical School, Botucatu/SPDepartment of Surgery Botucatu Medical School, Botucatu/SPDepartment of Internal Medicine Botucatu Medical School, Botucatu/SPDepartment of Surgery Botucatu Medical School, Botucatu/SPUniversidade Estadual Paulista (Unesp)Zanati, Silméia Garcia [UNESP]Mouraria, Guilherme Grisi [UNESP]Matsubara, Luiz Shiguero [UNESP]Giannini, Mariângela [UNESP]Matsubara, Beatriz Bojikian [UNESP]2014-05-27T11:23:56Z2014-05-27T11:23:56Z2009-07-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article323-326application/pdfhttp://dx.doi.org/10.1590/S1807-59322009000400010Clinics, v. 64, n. 4, p. 323-326, 2009.1807-5932http://hdl.handle.net/11449/7109410.1590/S1807-59322009000400010S1807-593220090004000102-s2.0-676506071852-s2.0-67650607185.pdf63098351379987666990977122340795Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinics1.2450,536info:eu-repo/semantics/openAccess2024-08-14T17:37:05Zoai:repositorio.unesp.br:11449/71094Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:37:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease
title Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease
spellingShingle Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease
Zanati, Silméia Garcia [UNESP]
Aspirin
Cardiovascular risk
Elderly
Smoking
Vascular surgery
acetylsalicylic acid
antithrombocytic agent
aged
Brazil
coronary artery disease
female
human
hypertension
Kaplan Meier method
male
mortality
peripheral vascular disease
prospective study
risk factor
smoking
survival
Aged
Coronary Artery Disease
Female
Humans
Hypertension
Kaplan-Meiers Estimate
Male
Peripheral Vascular Diseases
Platelet Aggregation Inhibitors
Prospective Studies
Risk Factors
Survival Analysis
title_short Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease
title_full Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease
title_fullStr Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease
title_full_unstemmed Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease
title_sort Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease
author Zanati, Silméia Garcia [UNESP]
author_facet Zanati, Silméia Garcia [UNESP]
Mouraria, Guilherme Grisi [UNESP]
Matsubara, Luiz Shiguero [UNESP]
Giannini, Mariângela [UNESP]
Matsubara, Beatriz Bojikian [UNESP]
author_role author
author2 Mouraria, Guilherme Grisi [UNESP]
Matsubara, Luiz Shiguero [UNESP]
Giannini, Mariângela [UNESP]
Matsubara, Beatriz Bojikian [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Zanati, Silméia Garcia [UNESP]
Mouraria, Guilherme Grisi [UNESP]
Matsubara, Luiz Shiguero [UNESP]
Giannini, Mariângela [UNESP]
Matsubara, Beatriz Bojikian [UNESP]
dc.subject.por.fl_str_mv Aspirin
Cardiovascular risk
Elderly
Smoking
Vascular surgery
acetylsalicylic acid
antithrombocytic agent
aged
Brazil
coronary artery disease
female
human
hypertension
Kaplan Meier method
male
mortality
peripheral vascular disease
prospective study
risk factor
smoking
survival
Aged
Coronary Artery Disease
Female
Humans
Hypertension
Kaplan-Meiers Estimate
Male
Peripheral Vascular Diseases
Platelet Aggregation Inhibitors
Prospective Studies
Risk Factors
Survival Analysis
topic Aspirin
Cardiovascular risk
Elderly
Smoking
Vascular surgery
acetylsalicylic acid
antithrombocytic agent
aged
Brazil
coronary artery disease
female
human
hypertension
Kaplan Meier method
male
mortality
peripheral vascular disease
prospective study
risk factor
smoking
survival
Aged
Coronary Artery Disease
Female
Humans
Hypertension
Kaplan-Meiers Estimate
Male
Peripheral Vascular Diseases
Platelet Aggregation Inhibitors
Prospective Studies
Risk Factors
Survival Analysis
description Introduction: The present study examines cardiovascular risk factor profiles and 24-month mortality in patients with symptomatic peripheral arterial disease. Design Study: Prospective observational study including 75 consecutive patients with PAD (67 ± 9.7 years of age; 52 men and 23 women) hospitalized for planned peripheral vascular reconstruction. Doppler echocardiograms were performed before surgery in 54 cases. Univariate analyses were performed using Student's t-test or Fisher's exact test. Survival analysis at 24-month follow-up was performed using the Cox regression model and Kaplan-Meier method including age and chronic use of aspirin as covariates. Survival curves were compared using the log-rank test. Results: Hypertension and smoking were the most frequent risk factors (52 cases and 51 cases, respectively), followed by diabetes (32 cases). Undertreated dyslipidemia was found in 26 cases. Fasting glycine levels (131 ± 69.1 mg/dl) were elevated in 29 cases. Myocardial hypertrophy was found in 18 out of 54 patients. Thirty-four patients had been treated with aspirin. Overall mortality over 24 months was 24% and was associated with age (HR: 0.064; CI95: 0.014-0.115; p=0.013) and lack of use of aspirin, as no deaths occurred among those using this drug (p<0.001). No association was found between cardiovascular death (11 cases) and the other risk factors. Conclusion: There is a high prevalence of uncontrolled (treated or untreated) cardiovascular risk factors in patients undergoing planned peripheral vascular reconstruction, and chronic use of aspirin is associated with reduced all-cause mortality in these patients.
publishDate 2009
dc.date.none.fl_str_mv 2009-07-22
2014-05-27T11:23:56Z
2014-05-27T11:23:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1807-59322009000400010
Clinics, v. 64, n. 4, p. 323-326, 2009.
1807-5932
http://hdl.handle.net/11449/71094
10.1590/S1807-59322009000400010
S1807-59322009000400010
2-s2.0-67650607185
2-s2.0-67650607185.pdf
6309835137998766
6990977122340795
url http://dx.doi.org/10.1590/S1807-59322009000400010
http://hdl.handle.net/11449/71094
identifier_str_mv Clinics, v. 64, n. 4, p. 323-326, 2009.
1807-5932
10.1590/S1807-59322009000400010
S1807-59322009000400010
2-s2.0-67650607185
2-s2.0-67650607185.pdf
6309835137998766
6990977122340795
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinics
1.245
0,536
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 323-326
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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