Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1807-59322009000400010 http://hdl.handle.net/11449/71094 |
Resumo: | Introduction: The present study examines cardiovascular risk factor profiles and 24-month mortality in patients with symptomatic peripheral arterial disease. Design Study: Prospective observational study including 75 consecutive patients with PAD (67 ± 9.7 years of age; 52 men and 23 women) hospitalized for planned peripheral vascular reconstruction. Doppler echocardiograms were performed before surgery in 54 cases. Univariate analyses were performed using Student's t-test or Fisher's exact test. Survival analysis at 24-month follow-up was performed using the Cox regression model and Kaplan-Meier method including age and chronic use of aspirin as covariates. Survival curves were compared using the log-rank test. Results: Hypertension and smoking were the most frequent risk factors (52 cases and 51 cases, respectively), followed by diabetes (32 cases). Undertreated dyslipidemia was found in 26 cases. Fasting glycine levels (131 ± 69.1 mg/dl) were elevated in 29 cases. Myocardial hypertrophy was found in 18 out of 54 patients. Thirty-four patients had been treated with aspirin. Overall mortality over 24 months was 24% and was associated with age (HR: 0.064; CI95: 0.014-0.115; p=0.013) and lack of use of aspirin, as no deaths occurred among those using this drug (p<0.001). No association was found between cardiovascular death (11 cases) and the other risk factors. Conclusion: There is a high prevalence of uncontrolled (treated or untreated) cardiovascular risk factors in patients undergoing planned peripheral vascular reconstruction, and chronic use of aspirin is associated with reduced all-cause mortality in these patients. |
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Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial diseaseAspirinCardiovascular riskElderlySmokingVascular surgeryacetylsalicylic acidantithrombocytic agentagedBrazilcoronary artery diseasefemalehumanhypertensionKaplan Meier methodmalemortalityperipheral vascular diseaseprospective studyrisk factorsmokingsurvivalAgedCoronary Artery DiseaseFemaleHumansHypertensionKaplan-Meiers EstimateMalePeripheral Vascular DiseasesPlatelet Aggregation InhibitorsProspective StudiesRisk FactorsSurvival AnalysisIntroduction: The present study examines cardiovascular risk factor profiles and 24-month mortality in patients with symptomatic peripheral arterial disease. Design Study: Prospective observational study including 75 consecutive patients with PAD (67 ± 9.7 years of age; 52 men and 23 women) hospitalized for planned peripheral vascular reconstruction. Doppler echocardiograms were performed before surgery in 54 cases. Univariate analyses were performed using Student's t-test or Fisher's exact test. Survival analysis at 24-month follow-up was performed using the Cox regression model and Kaplan-Meier method including age and chronic use of aspirin as covariates. Survival curves were compared using the log-rank test. Results: Hypertension and smoking were the most frequent risk factors (52 cases and 51 cases, respectively), followed by diabetes (32 cases). Undertreated dyslipidemia was found in 26 cases. Fasting glycine levels (131 ± 69.1 mg/dl) were elevated in 29 cases. Myocardial hypertrophy was found in 18 out of 54 patients. Thirty-four patients had been treated with aspirin. Overall mortality over 24 months was 24% and was associated with age (HR: 0.064; CI95: 0.014-0.115; p=0.013) and lack of use of aspirin, as no deaths occurred among those using this drug (p<0.001). No association was found between cardiovascular death (11 cases) and the other risk factors. Conclusion: There is a high prevalence of uncontrolled (treated or untreated) cardiovascular risk factors in patients undergoing planned peripheral vascular reconstruction, and chronic use of aspirin is associated with reduced all-cause mortality in these patients.Department of Internal Medicine Botucatu Medical School, Botucatu/SPDepartment of Surgery Botucatu Medical School, Botucatu/SPDepartment of Internal Medicine Botucatu Medical School, Botucatu/SPDepartment of Surgery Botucatu Medical School, Botucatu/SPUniversidade Estadual Paulista (Unesp)Zanati, Silméia Garcia [UNESP]Mouraria, Guilherme Grisi [UNESP]Matsubara, Luiz Shiguero [UNESP]Giannini, Mariângela [UNESP]Matsubara, Beatriz Bojikian [UNESP]2014-05-27T11:23:56Z2014-05-27T11:23:56Z2009-07-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article323-326application/pdfhttp://dx.doi.org/10.1590/S1807-59322009000400010Clinics, v. 64, n. 4, p. 323-326, 2009.1807-5932http://hdl.handle.net/11449/7109410.1590/S1807-59322009000400010S1807-593220090004000102-s2.0-676506071852-s2.0-67650607185.pdf63098351379987666990977122340795Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinics1.2450,536info:eu-repo/semantics/openAccess2024-08-14T17:37:05Zoai:repositorio.unesp.br:11449/71094Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:37:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease |
title |
Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease |
spellingShingle |
Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease Zanati, Silméia Garcia [UNESP] Aspirin Cardiovascular risk Elderly Smoking Vascular surgery acetylsalicylic acid antithrombocytic agent aged Brazil coronary artery disease female human hypertension Kaplan Meier method male mortality peripheral vascular disease prospective study risk factor smoking survival Aged Coronary Artery Disease Female Humans Hypertension Kaplan-Meiers Estimate Male Peripheral Vascular Diseases Platelet Aggregation Inhibitors Prospective Studies Risk Factors Survival Analysis |
title_short |
Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease |
title_full |
Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease |
title_fullStr |
Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease |
title_full_unstemmed |
Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease |
title_sort |
Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease |
author |
Zanati, Silméia Garcia [UNESP] |
author_facet |
Zanati, Silméia Garcia [UNESP] Mouraria, Guilherme Grisi [UNESP] Matsubara, Luiz Shiguero [UNESP] Giannini, Mariângela [UNESP] Matsubara, Beatriz Bojikian [UNESP] |
author_role |
author |
author2 |
Mouraria, Guilherme Grisi [UNESP] Matsubara, Luiz Shiguero [UNESP] Giannini, Mariângela [UNESP] Matsubara, Beatriz Bojikian [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Zanati, Silméia Garcia [UNESP] Mouraria, Guilherme Grisi [UNESP] Matsubara, Luiz Shiguero [UNESP] Giannini, Mariângela [UNESP] Matsubara, Beatriz Bojikian [UNESP] |
dc.subject.por.fl_str_mv |
Aspirin Cardiovascular risk Elderly Smoking Vascular surgery acetylsalicylic acid antithrombocytic agent aged Brazil coronary artery disease female human hypertension Kaplan Meier method male mortality peripheral vascular disease prospective study risk factor smoking survival Aged Coronary Artery Disease Female Humans Hypertension Kaplan-Meiers Estimate Male Peripheral Vascular Diseases Platelet Aggregation Inhibitors Prospective Studies Risk Factors Survival Analysis |
topic |
Aspirin Cardiovascular risk Elderly Smoking Vascular surgery acetylsalicylic acid antithrombocytic agent aged Brazil coronary artery disease female human hypertension Kaplan Meier method male mortality peripheral vascular disease prospective study risk factor smoking survival Aged Coronary Artery Disease Female Humans Hypertension Kaplan-Meiers Estimate Male Peripheral Vascular Diseases Platelet Aggregation Inhibitors Prospective Studies Risk Factors Survival Analysis |
description |
Introduction: The present study examines cardiovascular risk factor profiles and 24-month mortality in patients with symptomatic peripheral arterial disease. Design Study: Prospective observational study including 75 consecutive patients with PAD (67 ± 9.7 years of age; 52 men and 23 women) hospitalized for planned peripheral vascular reconstruction. Doppler echocardiograms were performed before surgery in 54 cases. Univariate analyses were performed using Student's t-test or Fisher's exact test. Survival analysis at 24-month follow-up was performed using the Cox regression model and Kaplan-Meier method including age and chronic use of aspirin as covariates. Survival curves were compared using the log-rank test. Results: Hypertension and smoking were the most frequent risk factors (52 cases and 51 cases, respectively), followed by diabetes (32 cases). Undertreated dyslipidemia was found in 26 cases. Fasting glycine levels (131 ± 69.1 mg/dl) were elevated in 29 cases. Myocardial hypertrophy was found in 18 out of 54 patients. Thirty-four patients had been treated with aspirin. Overall mortality over 24 months was 24% and was associated with age (HR: 0.064; CI95: 0.014-0.115; p=0.013) and lack of use of aspirin, as no deaths occurred among those using this drug (p<0.001). No association was found between cardiovascular death (11 cases) and the other risk factors. Conclusion: There is a high prevalence of uncontrolled (treated or untreated) cardiovascular risk factors in patients undergoing planned peripheral vascular reconstruction, and chronic use of aspirin is associated with reduced all-cause mortality in these patients. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-07-22 2014-05-27T11:23:56Z 2014-05-27T11:23:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1807-59322009000400010 Clinics, v. 64, n. 4, p. 323-326, 2009. 1807-5932 http://hdl.handle.net/11449/71094 10.1590/S1807-59322009000400010 S1807-59322009000400010 2-s2.0-67650607185 2-s2.0-67650607185.pdf 6309835137998766 6990977122340795 |
url |
http://dx.doi.org/10.1590/S1807-59322009000400010 http://hdl.handle.net/11449/71094 |
identifier_str_mv |
Clinics, v. 64, n. 4, p. 323-326, 2009. 1807-5932 10.1590/S1807-59322009000400010 S1807-59322009000400010 2-s2.0-67650607185 2-s2.0-67650607185.pdf 6309835137998766 6990977122340795 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinics 1.245 0,536 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
323-326 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128216099979264 |