Cardiovascular effects of histamine in three widely diverse species of reptiles
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00360-017-1108-3 http://hdl.handle.net/11449/174873 |
Resumo: | The cardiovascular system of vertebrates is regulated by a vast number of regulatory factors, including histamine. In pythons, histamine induces a strong tachycardia and dilates the systemic vasculature, which resembles the cardiovascular response to the elevated metabolic rate during digestion. In fact, there is an important role of increased histaminergic tone on the heart during the initial 24 h of digestion in pythons. Whilst the cardiovascular effects of histamine are well studied in pythons, little is known about the effects in other groups of reptiles. The histaminergic effects on the heart vary among species and histamine may exert either pressor and depressor effects by causing either constrictive or dilatory vascular responses. Here, we investigated the cardiovascular effects of histamine in three species of reptiles with very different cardiovascular and pulmonary morphologies. Experiments were performed on both anesthetized and recovered animals. We show a species-dependent effect of histamine on the systemic vasculature with dilation in rattlesnakes and constriction in turtles and caimans but no effect on the pulmonary circulation. The histamine-induced dilation in rattlesnakes was mediated through an activation of H2-receptors, whereas the histamine-induced constriction in caimans was mediated through both adrenergic signaling and H1-receptors activation. In all three species, histamine-induced tachycardia by direct stimulation of histaminergic receptors as well as an indirect activation of adrenoreceptors. This finding highlights a more complex mechanism underlying the action of histamine than previously recognized in reptiles. |
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Cardiovascular effects of histamine in three widely diverse species of reptilesAdrenergicHeart rateHistamine receptorHistaminergicVascular resistanceThe cardiovascular system of vertebrates is regulated by a vast number of regulatory factors, including histamine. In pythons, histamine induces a strong tachycardia and dilates the systemic vasculature, which resembles the cardiovascular response to the elevated metabolic rate during digestion. In fact, there is an important role of increased histaminergic tone on the heart during the initial 24 h of digestion in pythons. Whilst the cardiovascular effects of histamine are well studied in pythons, little is known about the effects in other groups of reptiles. The histaminergic effects on the heart vary among species and histamine may exert either pressor and depressor effects by causing either constrictive or dilatory vascular responses. Here, we investigated the cardiovascular effects of histamine in three species of reptiles with very different cardiovascular and pulmonary morphologies. Experiments were performed on both anesthetized and recovered animals. We show a species-dependent effect of histamine on the systemic vasculature with dilation in rattlesnakes and constriction in turtles and caimans but no effect on the pulmonary circulation. The histamine-induced dilation in rattlesnakes was mediated through an activation of H2-receptors, whereas the histamine-induced constriction in caimans was mediated through both adrenergic signaling and H1-receptors activation. In all three species, histamine-induced tachycardia by direct stimulation of histaminergic receptors as well as an indirect activation of adrenoreceptors. This finding highlights a more complex mechanism underlying the action of histamine than previously recognized in reptiles.Natur og Univers, Det Frie ForskningsrådZoophysiology Department of Bioscience Aarhus University, C.f. Møllers Allé 3, Building 1131Departamento de Zoologia Centro de Aquicultura UNESPSchool of Biosciences University of BirminghamDepartamento de Zoologia Centro de Aquicultura UNESPAarhus UniversityUniversidade Estadual Paulista (Unesp)University of BirminghamSkovgaard, Nini [UNESP]Abe, Augusto S. [UNESP]Taylor, Edwin W. [UNESP]Wang, Tobias [UNESP]2018-12-11T17:13:15Z2018-12-11T17:13:15Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article153-162application/pdfhttp://dx.doi.org/10.1007/s00360-017-1108-3Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, v. 188, n. 1, p. 153-162, 2018.0174-1578http://hdl.handle.net/11449/17487310.1007/s00360-017-1108-32-s2.0-850222206472-s2.0-85022220647.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology0,952info:eu-repo/semantics/openAccess2024-04-09T15:43:35Zoai:repositorio.unesp.br:11449/174873Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-09T15:43:35Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cardiovascular effects of histamine in three widely diverse species of reptiles |
title |
Cardiovascular effects of histamine in three widely diverse species of reptiles |
spellingShingle |
Cardiovascular effects of histamine in three widely diverse species of reptiles Skovgaard, Nini [UNESP] Adrenergic Heart rate Histamine receptor Histaminergic Vascular resistance |
title_short |
Cardiovascular effects of histamine in three widely diverse species of reptiles |
title_full |
Cardiovascular effects of histamine in three widely diverse species of reptiles |
title_fullStr |
Cardiovascular effects of histamine in three widely diverse species of reptiles |
title_full_unstemmed |
Cardiovascular effects of histamine in three widely diverse species of reptiles |
title_sort |
Cardiovascular effects of histamine in three widely diverse species of reptiles |
author |
Skovgaard, Nini [UNESP] |
author_facet |
Skovgaard, Nini [UNESP] Abe, Augusto S. [UNESP] Taylor, Edwin W. [UNESP] Wang, Tobias [UNESP] |
author_role |
author |
author2 |
Abe, Augusto S. [UNESP] Taylor, Edwin W. [UNESP] Wang, Tobias [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Aarhus University Universidade Estadual Paulista (Unesp) University of Birmingham |
dc.contributor.author.fl_str_mv |
Skovgaard, Nini [UNESP] Abe, Augusto S. [UNESP] Taylor, Edwin W. [UNESP] Wang, Tobias [UNESP] |
dc.subject.por.fl_str_mv |
Adrenergic Heart rate Histamine receptor Histaminergic Vascular resistance |
topic |
Adrenergic Heart rate Histamine receptor Histaminergic Vascular resistance |
description |
The cardiovascular system of vertebrates is regulated by a vast number of regulatory factors, including histamine. In pythons, histamine induces a strong tachycardia and dilates the systemic vasculature, which resembles the cardiovascular response to the elevated metabolic rate during digestion. In fact, there is an important role of increased histaminergic tone on the heart during the initial 24 h of digestion in pythons. Whilst the cardiovascular effects of histamine are well studied in pythons, little is known about the effects in other groups of reptiles. The histaminergic effects on the heart vary among species and histamine may exert either pressor and depressor effects by causing either constrictive or dilatory vascular responses. Here, we investigated the cardiovascular effects of histamine in three species of reptiles with very different cardiovascular and pulmonary morphologies. Experiments were performed on both anesthetized and recovered animals. We show a species-dependent effect of histamine on the systemic vasculature with dilation in rattlesnakes and constriction in turtles and caimans but no effect on the pulmonary circulation. The histamine-induced dilation in rattlesnakes was mediated through an activation of H2-receptors, whereas the histamine-induced constriction in caimans was mediated through both adrenergic signaling and H1-receptors activation. In all three species, histamine-induced tachycardia by direct stimulation of histaminergic receptors as well as an indirect activation of adrenoreceptors. This finding highlights a more complex mechanism underlying the action of histamine than previously recognized in reptiles. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:13:15Z 2018-12-11T17:13:15Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00360-017-1108-3 Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, v. 188, n. 1, p. 153-162, 2018. 0174-1578 http://hdl.handle.net/11449/174873 10.1007/s00360-017-1108-3 2-s2.0-85022220647 2-s2.0-85022220647.pdf |
url |
http://dx.doi.org/10.1007/s00360-017-1108-3 http://hdl.handle.net/11449/174873 |
identifier_str_mv |
Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, v. 188, n. 1, p. 153-162, 2018. 0174-1578 10.1007/s00360-017-1108-3 2-s2.0-85022220647 2-s2.0-85022220647.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology 0,952 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
153-162 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965635955916800 |